The Role of m<sup>6</sup>A Modifications in B-Cell Development and B-Cell-Related Diseases
B cells are a class of professional antigen-presenting cells that produce antibodies to mediate humoral immune response and participate in immune regulation. m<sup>6</sup>A modification is the most common RNA modification in mRNA; it involves almost all aspects of RNA metabolism and can...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/5/4721 |
| Summary: | B cells are a class of professional antigen-presenting cells that produce antibodies to mediate humoral immune response and participate in immune regulation. m<sup>6</sup>A modification is the most common RNA modification in mRNA; it involves almost all aspects of RNA metabolism and can affect RNA splicing, translation, stability, etc. This review focuses on the B-cell maturation process as well as the role of three m<sup>6</sup>A modification-related regulators—writer, eraser, and reader—in B-cell development and B-cell-related diseases. The identification of genes and modifiers that contribute to immune deficiency may shed light on regulatory requirements for normal B-cell development and the underlying mechanism of some common diseases. |
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| ISSN: | 1661-6596 1422-0067 |