The Role of m<sup>6</sup>A Modifications in B-Cell Development and B-Cell-Related Diseases
B cells are a class of professional antigen-presenting cells that produce antibodies to mediate humoral immune response and participate in immune regulation. m<sup>6</sup>A modification is the most common RNA modification in mRNA; it involves almost all aspects of RNA metabolism and can...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/5/4721 |
| _version_ | 1797615199413338112 |
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| author | Shuqi Wang Huanxiang Li Zhengxing Lian Shoulong Deng |
| author_facet | Shuqi Wang Huanxiang Li Zhengxing Lian Shoulong Deng |
| author_sort | Shuqi Wang |
| collection | DOAJ |
| description | B cells are a class of professional antigen-presenting cells that produce antibodies to mediate humoral immune response and participate in immune regulation. m<sup>6</sup>A modification is the most common RNA modification in mRNA; it involves almost all aspects of RNA metabolism and can affect RNA splicing, translation, stability, etc. This review focuses on the B-cell maturation process as well as the role of three m<sup>6</sup>A modification-related regulators—writer, eraser, and reader—in B-cell development and B-cell-related diseases. The identification of genes and modifiers that contribute to immune deficiency may shed light on regulatory requirements for normal B-cell development and the underlying mechanism of some common diseases. |
| first_indexed | 2024-03-11T07:23:00Z |
| format | Article |
| id | doaj.art-d54105a086b44d2882a88b7785948e02 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T07:23:00Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-d54105a086b44d2882a88b7785948e022023-11-17T07:52:27ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-03-01245472110.3390/ijms24054721The Role of m<sup>6</sup>A Modifications in B-Cell Development and B-Cell-Related DiseasesShuqi Wang0Huanxiang Li1Zhengxing Lian2Shoulong Deng3Beijing Key Laboratory for Animal Genetic Improvement, National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics and Breeding of the Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing 100193, ChinaBeijing Key Laboratory for Animal Genetic Improvement, National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics and Breeding of the Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing 100193, ChinaBeijing Key Laboratory for Animal Genetic Improvement, National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics and Breeding of the Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing 100193, ChinaNHC Key Laboratory of Human Disease Comparative Medicine, Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing 100021, ChinaB cells are a class of professional antigen-presenting cells that produce antibodies to mediate humoral immune response and participate in immune regulation. m<sup>6</sup>A modification is the most common RNA modification in mRNA; it involves almost all aspects of RNA metabolism and can affect RNA splicing, translation, stability, etc. This review focuses on the B-cell maturation process as well as the role of three m<sup>6</sup>A modification-related regulators—writer, eraser, and reader—in B-cell development and B-cell-related diseases. The identification of genes and modifiers that contribute to immune deficiency may shed light on regulatory requirements for normal B-cell development and the underlying mechanism of some common diseases.https://www.mdpi.com/1422-0067/24/5/4721B cellimmunodeficiencym<sup>6</sup>AB-cell-related diseases |
| spellingShingle | Shuqi Wang Huanxiang Li Zhengxing Lian Shoulong Deng The Role of m<sup>6</sup>A Modifications in B-Cell Development and B-Cell-Related Diseases International Journal of Molecular Sciences B cell immunodeficiency m<sup>6</sup>A B-cell-related diseases |
| title | The Role of m<sup>6</sup>A Modifications in B-Cell Development and B-Cell-Related Diseases |
| title_full | The Role of m<sup>6</sup>A Modifications in B-Cell Development and B-Cell-Related Diseases |
| title_fullStr | The Role of m<sup>6</sup>A Modifications in B-Cell Development and B-Cell-Related Diseases |
| title_full_unstemmed | The Role of m<sup>6</sup>A Modifications in B-Cell Development and B-Cell-Related Diseases |
| title_short | The Role of m<sup>6</sup>A Modifications in B-Cell Development and B-Cell-Related Diseases |
| title_sort | role of m sup 6 sup a modifications in b cell development and b cell related diseases |
| topic | B cell immunodeficiency m<sup>6</sup>A B-cell-related diseases |
| url | https://www.mdpi.com/1422-0067/24/5/4721 |
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