Mapping protein states and interactions across the tree of life with co-fractionation mass spectrometry
Abstract We present CFdb, a harmonized resource of interaction proteomics data from 411 co-fractionation mass spectrometry (CF-MS) datasets spanning 21,703 fractions. Meta-analysis of this resource charts protein abundance, phosphorylation, and interactions throughout the tree of life, including a r...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-44139-5 |
| _version_ | 1827581525718204416 |
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| author | Michael A. Skinnider Mopelola O. Akinlaja Leonard J. Foster |
| author_facet | Michael A. Skinnider Mopelola O. Akinlaja Leonard J. Foster |
| author_sort | Michael A. Skinnider |
| collection | DOAJ |
| description | Abstract We present CFdb, a harmonized resource of interaction proteomics data from 411 co-fractionation mass spectrometry (CF-MS) datasets spanning 21,703 fractions. Meta-analysis of this resource charts protein abundance, phosphorylation, and interactions throughout the tree of life, including a reference map of the human interactome. We show how large-scale CF-MS data can enhance analyses of individual CF-MS datasets, and exemplify this strategy by mapping the honey bee interactome. |
| first_indexed | 2024-03-08T22:37:49Z |
| format | Article |
| id | doaj.art-d541b789500840e8affe27b782bc61b7 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-08T22:37:49Z |
| publishDate | 2023-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-d541b789500840e8affe27b782bc61b72023-12-17T12:24:05ZengNature PortfolioNature Communications2041-17232023-12-0114111110.1038/s41467-023-44139-5Mapping protein states and interactions across the tree of life with co-fractionation mass spectrometryMichael A. Skinnider0Mopelola O. Akinlaja1Leonard J. Foster2Michael Smith Laboratories, University of British ColumbiaMichael Smith Laboratories, University of British ColumbiaMichael Smith Laboratories, University of British ColumbiaAbstract We present CFdb, a harmonized resource of interaction proteomics data from 411 co-fractionation mass spectrometry (CF-MS) datasets spanning 21,703 fractions. Meta-analysis of this resource charts protein abundance, phosphorylation, and interactions throughout the tree of life, including a reference map of the human interactome. We show how large-scale CF-MS data can enhance analyses of individual CF-MS datasets, and exemplify this strategy by mapping the honey bee interactome.https://doi.org/10.1038/s41467-023-44139-5 |
| spellingShingle | Michael A. Skinnider Mopelola O. Akinlaja Leonard J. Foster Mapping protein states and interactions across the tree of life with co-fractionation mass spectrometry Nature Communications |
| title | Mapping protein states and interactions across the tree of life with co-fractionation mass spectrometry |
| title_full | Mapping protein states and interactions across the tree of life with co-fractionation mass spectrometry |
| title_fullStr | Mapping protein states and interactions across the tree of life with co-fractionation mass spectrometry |
| title_full_unstemmed | Mapping protein states and interactions across the tree of life with co-fractionation mass spectrometry |
| title_short | Mapping protein states and interactions across the tree of life with co-fractionation mass spectrometry |
| title_sort | mapping protein states and interactions across the tree of life with co fractionation mass spectrometry |
| url | https://doi.org/10.1038/s41467-023-44139-5 |
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