Hypoxia Modifies the Transcriptome of Human NK Cells, Modulates Their Immunoregulatory Profile, and Influences NK Cell Subset Migration

Hypoxia Modifies the Transcriptome of Human NK Cells, Modulates Their Immunoregulatory Profile, and Influences NK Cell Subset Migration

Hypoxia, which characterizes most tumor tissues, can alter the function of different immune cell types, favoring tumor escape mechanisms. In this study, we show that hypoxia profoundly acts on NK cells by influencing their transcriptome, affecting their immunoregulatory functions, and changing the c...

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Bibliographic Details
Main Authors: Monica Parodi, Federica Raggi, Davide Cangelosi, Claudia Manzini, Mirna Balsamo, Fabiola Blengio, Alessandra Eva, Luigi Varesio, Gabriella Pietra, Lorenzo Moretta, Maria Cristina Mingari, Massimo Vitale, Maria Carla Bosco
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
NK cells
hypoxia
tumor immunology
cytokines/chemokines
chemokine receptors
CD56bright cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02358/full

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