Measurement of Cancer Cell Growth Heterogeneity through Lentiviral Barcoding Identifies Clonal Dominance as a Characteristic of In Vivo Tumor Engraftment.

Advances in the fields of cancer initiating cells and high-throughput in vivo shRNA screens have highlighted a need to observe the growth of tumor cells in cancer models at the clonal level. While in vivo cancer cell growth heterogeneity in xenografts has been described, it has yet to be measured. H...

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Detalles Bibliográficos
Main Authors: Olivier Nolan-Stevaux, Donato Tedesco, Seamus Ragan, Mikhail Makhanov, Alex Chenchik, Astrid Ruefli-Brasse, Kim Quon, Paul D Kassner
Formato: Artigo
Idioma:English
Publicado: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Acceso en liña:http://europepmc.org/articles/PMC3693957?pdf=render

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