Circulating Serum VEGF, IGF-1 and MMP-9 and Expression of Their Genes as Potential Prognostic Markers of Recovery in Post-Stroke Rehabilitation—A Prospective Observational Study
The key period in post-stroke recovery is the first three months due to the high activity of spontaneous and therapeutic-induced processes related to neuroplasticity, angiogenesis and reperfusion. Therefore, the present study examines the expression of VEGF, IGF-1 and MMP-9 proteins and their genes...
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MDPI AG
2023-05-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/13/6/846 |
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| author | Lidia Włodarczyk Natalia Cichoń Michał Seweryn Karbownik Luciano Saso Joanna Saluk Elżbieta Miller |
| author_facet | Lidia Włodarczyk Natalia Cichoń Michał Seweryn Karbownik Luciano Saso Joanna Saluk Elżbieta Miller |
| author_sort | Lidia Włodarczyk |
| collection | DOAJ |
| description | The key period in post-stroke recovery is the first three months due to the high activity of spontaneous and therapeutic-induced processes related to neuroplasticity, angiogenesis and reperfusion. Therefore, the present study examines the expression of VEGF, IGF-1 and MMP-9 proteins and their genes to identify biomarkers that can prognose brain repair ability and thus estimate the outcome of stroke. It also identifies possible associations with clinical scales, including cognitive assessment and depression scales. The study group comprised 32 patients with moderate ischemic stroke severity, three to four weeks after incident. The results obtained after three-week hospitalization indicate a statistically significant change in clinical parameter estimations, as well as in MMP9 and VEGF protein and mRNA expression, over the rehabilitation process. Our findings indicate that combined MMP9 protein and mRNA expression might be a useful biomarker for cognitive improvement in post-stroke patients, demonstrating 87% sensitivity and 71% specificity (<i>p</i> < 0.0001). |
| first_indexed | 2024-03-11T02:41:10Z |
| format | Article |
| id | doaj.art-d5443946d3f444a9a6eeea91e01b9458 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-11T02:41:10Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-d5443946d3f444a9a6eeea91e01b94582023-11-18T09:35:23ZengMDPI AGBrain Sciences2076-34252023-05-0113684610.3390/brainsci13060846Circulating Serum VEGF, IGF-1 and MMP-9 and Expression of Their Genes as Potential Prognostic Markers of Recovery in Post-Stroke Rehabilitation—A Prospective Observational StudyLidia Włodarczyk0Natalia Cichoń1Michał Seweryn Karbownik2Luciano Saso3Joanna Saluk4Elżbieta Miller5Department of Neurological Rehabilitation, Medical University of Lodz, Milionowa 14, 93-113 Lodz, PolandBiohazard Prevention Centre, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, PolandDepartment of Pharmacology and Toxicology, Medical University of Lodz, Żeligowskiego 7/9, 90-752 Lodz, PolandDepartment of Physiology and Pharmacology “Vittorio Erspamer”, Sapienza University, P. le Aldo Moro 5, 00185 Rome, ItalyDepartment of General Biochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, PolandDepartment of Neurological Rehabilitation, Medical University of Lodz, Milionowa 14, 93-113 Lodz, PolandThe key period in post-stroke recovery is the first three months due to the high activity of spontaneous and therapeutic-induced processes related to neuroplasticity, angiogenesis and reperfusion. Therefore, the present study examines the expression of VEGF, IGF-1 and MMP-9 proteins and their genes to identify biomarkers that can prognose brain repair ability and thus estimate the outcome of stroke. It also identifies possible associations with clinical scales, including cognitive assessment and depression scales. The study group comprised 32 patients with moderate ischemic stroke severity, three to four weeks after incident. The results obtained after three-week hospitalization indicate a statistically significant change in clinical parameter estimations, as well as in MMP9 and VEGF protein and mRNA expression, over the rehabilitation process. Our findings indicate that combined MMP9 protein and mRNA expression might be a useful biomarker for cognitive improvement in post-stroke patients, demonstrating 87% sensitivity and 71% specificity (<i>p</i> < 0.0001).https://www.mdpi.com/2076-3425/13/6/846strokerecoverybiomarkerrehabilitation |
| spellingShingle | Lidia Włodarczyk Natalia Cichoń Michał Seweryn Karbownik Luciano Saso Joanna Saluk Elżbieta Miller Circulating Serum VEGF, IGF-1 and MMP-9 and Expression of Their Genes as Potential Prognostic Markers of Recovery in Post-Stroke Rehabilitation—A Prospective Observational Study Brain Sciences stroke recovery biomarker rehabilitation |
| title | Circulating Serum VEGF, IGF-1 and MMP-9 and Expression of Their Genes as Potential Prognostic Markers of Recovery in Post-Stroke Rehabilitation—A Prospective Observational Study |
| title_full | Circulating Serum VEGF, IGF-1 and MMP-9 and Expression of Their Genes as Potential Prognostic Markers of Recovery in Post-Stroke Rehabilitation—A Prospective Observational Study |
| title_fullStr | Circulating Serum VEGF, IGF-1 and MMP-9 and Expression of Their Genes as Potential Prognostic Markers of Recovery in Post-Stroke Rehabilitation—A Prospective Observational Study |
| title_full_unstemmed | Circulating Serum VEGF, IGF-1 and MMP-9 and Expression of Their Genes as Potential Prognostic Markers of Recovery in Post-Stroke Rehabilitation—A Prospective Observational Study |
| title_short | Circulating Serum VEGF, IGF-1 and MMP-9 and Expression of Their Genes as Potential Prognostic Markers of Recovery in Post-Stroke Rehabilitation—A Prospective Observational Study |
| title_sort | circulating serum vegf igf 1 and mmp 9 and expression of their genes as potential prognostic markers of recovery in post stroke rehabilitation a prospective observational study |
| topic | stroke recovery biomarker rehabilitation |
| url | https://www.mdpi.com/2076-3425/13/6/846 |
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