An intracellular isotropic diffusion signal is positively associated with pubertal development in white matter
Puberty is a key event in adolescent development that involves significant, hormone-driven changes to many aspects of physiology including the brain. Understanding how the brain responds during this time period is important for evaluating neuronal developments that affect mental health throughout ad...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-10-01
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| Series: | Developmental Cognitive Neuroscience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878929323001068 |
| _version_ | 1797671426189164544 |
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| author | Benjamin T. Newman James T. Patrie T. Jason Druzgal |
| author_facet | Benjamin T. Newman James T. Patrie T. Jason Druzgal |
| author_sort | Benjamin T. Newman |
| collection | DOAJ |
| description | Puberty is a key event in adolescent development that involves significant, hormone-driven changes to many aspects of physiology including the brain. Understanding how the brain responds during this time period is important for evaluating neuronal developments that affect mental health throughout adolescence and the adult lifespan. This study examines diffusion MRI scans from the cross-sectional ABCD Study baseline cohort, a large multi-site study containing thousands of participants, to describe the relationship between pubertal development and brain microstructure. Using advanced, 3-tissue constrained spherical deconvolution methods, this study is able to describe multiple tissue compartments beyond only white matter (WM) axonal qualities. After controlling for age, sex, brain volume, subject handedness, scanning site, and sibling relationships, we observe a positive relationship between an isotropic, intracellular diffusion signal fraction and pubertal development across a majority of regions of interest (ROIs) in the WM skeleton. We also observe regional effects from an intracellular anisotropic signal fraction compartment and extracellular isotropic free water-like compartment in several ROIs. This cross-sectional work suggests that changes in pubertal status are associated with a complex response from brain tissue that cannot be completely described by traditional methods focusing only on WM axonal properties. |
| first_indexed | 2024-03-11T21:15:21Z |
| format | Article |
| id | doaj.art-d54441f312f840fbafe24b1e0a5f1c33 |
| institution | Directory Open Access Journal |
| issn | 1878-9293 |
| language | English |
| last_indexed | 2024-03-11T21:15:21Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Developmental Cognitive Neuroscience |
| spelling | doaj.art-d54441f312f840fbafe24b1e0a5f1c332023-09-29T04:44:01ZengElsevierDevelopmental Cognitive Neuroscience1878-92932023-10-0163101301An intracellular isotropic diffusion signal is positively associated with pubertal development in white matterBenjamin T. Newman0James T. Patrie1T. Jason Druzgal2Department of Radiology and Medical Imaging, School of Medicine, University of Virginia, USA; Correspondence to: MR4 409 Lane Road, Charlottesville, VA 22903, USA.Department of Public Health Sciences, School of Medicine, University of Virginia, USADepartment of Radiology and Medical Imaging, School of Medicine, University of Virginia, USAPuberty is a key event in adolescent development that involves significant, hormone-driven changes to many aspects of physiology including the brain. Understanding how the brain responds during this time period is important for evaluating neuronal developments that affect mental health throughout adolescence and the adult lifespan. This study examines diffusion MRI scans from the cross-sectional ABCD Study baseline cohort, a large multi-site study containing thousands of participants, to describe the relationship between pubertal development and brain microstructure. Using advanced, 3-tissue constrained spherical deconvolution methods, this study is able to describe multiple tissue compartments beyond only white matter (WM) axonal qualities. After controlling for age, sex, brain volume, subject handedness, scanning site, and sibling relationships, we observe a positive relationship between an isotropic, intracellular diffusion signal fraction and pubertal development across a majority of regions of interest (ROIs) in the WM skeleton. We also observe regional effects from an intracellular anisotropic signal fraction compartment and extracellular isotropic free water-like compartment in several ROIs. This cross-sectional work suggests that changes in pubertal status are associated with a complex response from brain tissue that cannot be completely described by traditional methods focusing only on WM axonal properties.http://www.sciencedirect.com/science/article/pii/S1878929323001068DiffusionMicrostructureMRIDevelopmentPuberty |
| spellingShingle | Benjamin T. Newman James T. Patrie T. Jason Druzgal An intracellular isotropic diffusion signal is positively associated with pubertal development in white matter Developmental Cognitive Neuroscience Diffusion Microstructure MRI Development Puberty |
| title | An intracellular isotropic diffusion signal is positively associated with pubertal development in white matter |
| title_full | An intracellular isotropic diffusion signal is positively associated with pubertal development in white matter |
| title_fullStr | An intracellular isotropic diffusion signal is positively associated with pubertal development in white matter |
| title_full_unstemmed | An intracellular isotropic diffusion signal is positively associated with pubertal development in white matter |
| title_short | An intracellular isotropic diffusion signal is positively associated with pubertal development in white matter |
| title_sort | intracellular isotropic diffusion signal is positively associated with pubertal development in white matter |
| topic | Diffusion Microstructure MRI Development Puberty |
| url | http://www.sciencedirect.com/science/article/pii/S1878929323001068 |
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