Molecular Mechanisms and Risk Factors Related to the Pathogenesis of Peyronie’s Disease
Peyronie’s disease (PD) is a benign condition caused by plaque formation on the tunica albuginea of the penis. It is associated with penile pain, curvature, and shortening, and contributes to erectile dysfunction, which worsens patient quality of life. In recent years, research into understanding of...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/12/10133 |
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| author | Yozo Mitsui Fumito Yamabe Shunsuke Hori Masato Uetani Hideyuki Kobayashi Koichi Nagao Koichi Nakajima |
| author_facet | Yozo Mitsui Fumito Yamabe Shunsuke Hori Masato Uetani Hideyuki Kobayashi Koichi Nagao Koichi Nakajima |
| author_sort | Yozo Mitsui |
| collection | DOAJ |
| description | Peyronie’s disease (PD) is a benign condition caused by plaque formation on the tunica albuginea of the penis. It is associated with penile pain, curvature, and shortening, and contributes to erectile dysfunction, which worsens patient quality of life. In recent years, research into understanding of the detailed mechanisms and risk factors involved in the development of PD has been increasing. In this review, the pathological mechanisms and several closely related signaling pathways, including TGF-β, WNT/β-catenin, Hedgehog, YAP/TAZ, MAPK, ROCK, and PI3K/AKT, are described. Findings regarding cross-talk among these pathways are then discussed to elucidate the complicated cascade behind tunica albuginea fibrosis. Finally, various risk factors including the genes involved in the development of PD are presented and their association with the disease summarized. The purpose of this review is to provide a better understanding regarding the involvement of risk factors in the molecular mechanisms associated with PD pathogenesis, as well as to provide insight into disease prevention and novel therapeutic interventions. |
| first_indexed | 2024-03-11T02:21:51Z |
| format | Article |
| id | doaj.art-d5446075e7474d48a1a1a5bbe09b8adf |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T02:21:51Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-d5446075e7474d48a1a1a5bbe09b8adf2023-11-18T10:49:04ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-06-0124121013310.3390/ijms241210133Molecular Mechanisms and Risk Factors Related to the Pathogenesis of Peyronie’s DiseaseYozo Mitsui0Fumito Yamabe1Shunsuke Hori2Masato Uetani3Hideyuki Kobayashi4Koichi Nagao5Koichi Nakajima6Department of Urology, Toho University Faculty of Medicine, Tokyo 143-8540, JapanDepartment of Urology, Toho University Faculty of Medicine, Tokyo 143-8540, JapanDepartment of Urology, Toho University Faculty of Medicine, Tokyo 143-8540, JapanDepartment of Urology, Toho University Faculty of Medicine, Tokyo 143-8540, JapanDepartment of Urology, Toho University Faculty of Medicine, Tokyo 143-8540, JapanDepartment of Urology, Toho University Faculty of Medicine, Tokyo 143-8540, JapanDepartment of Urology, Toho University Faculty of Medicine, Tokyo 143-8540, JapanPeyronie’s disease (PD) is a benign condition caused by plaque formation on the tunica albuginea of the penis. It is associated with penile pain, curvature, and shortening, and contributes to erectile dysfunction, which worsens patient quality of life. In recent years, research into understanding of the detailed mechanisms and risk factors involved in the development of PD has been increasing. In this review, the pathological mechanisms and several closely related signaling pathways, including TGF-β, WNT/β-catenin, Hedgehog, YAP/TAZ, MAPK, ROCK, and PI3K/AKT, are described. Findings regarding cross-talk among these pathways are then discussed to elucidate the complicated cascade behind tunica albuginea fibrosis. Finally, various risk factors including the genes involved in the development of PD are presented and their association with the disease summarized. The purpose of this review is to provide a better understanding regarding the involvement of risk factors in the molecular mechanisms associated with PD pathogenesis, as well as to provide insight into disease prevention and novel therapeutic interventions.https://www.mdpi.com/1422-0067/24/12/10133Peyronie’s diseasepathogenesisrisk factorsmolecular mechanismstransforming growth factor-β1 |
| spellingShingle | Yozo Mitsui Fumito Yamabe Shunsuke Hori Masato Uetani Hideyuki Kobayashi Koichi Nagao Koichi Nakajima Molecular Mechanisms and Risk Factors Related to the Pathogenesis of Peyronie’s Disease International Journal of Molecular Sciences Peyronie’s disease pathogenesis risk factors molecular mechanisms transforming growth factor-β1 |
| title | Molecular Mechanisms and Risk Factors Related to the Pathogenesis of Peyronie’s Disease |
| title_full | Molecular Mechanisms and Risk Factors Related to the Pathogenesis of Peyronie’s Disease |
| title_fullStr | Molecular Mechanisms and Risk Factors Related to the Pathogenesis of Peyronie’s Disease |
| title_full_unstemmed | Molecular Mechanisms and Risk Factors Related to the Pathogenesis of Peyronie’s Disease |
| title_short | Molecular Mechanisms and Risk Factors Related to the Pathogenesis of Peyronie’s Disease |
| title_sort | molecular mechanisms and risk factors related to the pathogenesis of peyronie s disease |
| topic | Peyronie’s disease pathogenesis risk factors molecular mechanisms transforming growth factor-β1 |
| url | https://www.mdpi.com/1422-0067/24/12/10133 |
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