Association of Glutathione S-transferase Genes (M1 and T1) with the Risk of Acute Myeloid Leukemia in a Moroccan Population
Background: Acute myeloid leukemia, as most cancers, results from exposure to carcinogens and an impaired inherited individual capacity to eliminate xenobiotics. The present case-control study measures the relationship between glutathione S-transferase (GST) T1 and M1 null genotypes and the risk...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Shiraz University of Medical Sciences
2017-01-01
|
| Series: | Middle East Journal of Cancer |
| Subjects: | |
| Online Access: | http://mejc.sums.ac.ir/index.php/mejc/article/view/435/289 |
| Summary: | Background: Acute myeloid leukemia, as most cancers, results from exposure to
carcinogens and an impaired inherited individual capacity to eliminate xenobiotics. The
present case-control study measures the relationship between glutathione S-transferase
(GST) T1 and M1 null genotypes and the risk of acute myeloid leukemia.
Methods: We identified the GSTT1 andGSTM1 genotypes by multiplex polymerase
chain reaction in 129 acute myeloid leukemia patients and 129 controls.
Results: Individuals that carried GSTT1 null had a risk of acute myeloid leukemia
when compared to GSTT1 present carriers (OR: 2.80; 95% CI: 1.63-4.80, P=0.00036).
However, GSTM1 null did not influence the risk for acute myeloid leukemia (OR: 1.20;
95% CI: 0.72-1.97, P=0.53). The combined GSTT1 null/GSTM1 present genotype
showed an association with the risk for acute myeloid leukemia compared to those that
carried both functional genotypes (OR: 8.85; 95% CI: 3.09-23.8, P=0.0001). The
double null genotype also showed an association with the risk for acute myeloid
leukemia (OR: 2.32, 95% CI: 1.15-4.66, P=0.019).
Conclusion: Both GSTT1 null and GST double-null genotypes may be risk factors
for acute myeloid leukemia. Further studies are needed to confirm these results. |
|---|---|
| ISSN: | 2008-6709 2008-6687 |