<i>Toxoplasma gondii</i> Infection Is Associated with Low Birth Weight: Findings from an Observational Study among Rural Bangladeshi Women
Gestational <i>Toxoplasma gondii</i> (<i>T. gondii</i>) infection may cause substantial adverse effects on developing fetuses, newborns and also mothers. This study aims to estimate the seroprevalence of <i>T. gondii</i> among rural Bangladeshi pregnant women and...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/11/3/336 |
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| author | Irin Parvin Sumon Kumar Das Shahnawaz Ahmed Aminur Rahman Abu Sadat Mohammad Sayeem Bin Shahid Lubaba Shahrin Farzana Afroze Mst. Mahmuda Ackhter Tahmina Alam Yasmin Jahan Parag Palit Mohammad Habibur Rahman Sarker Jui Das Mohammad Enamul Hoque Ricardo J. Soares Magalhães Abdullah Al Mamun Abu Syed Golam Faruque Tahmeed Ahmed Mohammod Jobayer Chisti |
| author_facet | Irin Parvin Sumon Kumar Das Shahnawaz Ahmed Aminur Rahman Abu Sadat Mohammad Sayeem Bin Shahid Lubaba Shahrin Farzana Afroze Mst. Mahmuda Ackhter Tahmina Alam Yasmin Jahan Parag Palit Mohammad Habibur Rahman Sarker Jui Das Mohammad Enamul Hoque Ricardo J. Soares Magalhães Abdullah Al Mamun Abu Syed Golam Faruque Tahmeed Ahmed Mohammod Jobayer Chisti |
| author_sort | Irin Parvin |
| collection | DOAJ |
| description | Gestational <i>Toxoplasma gondii</i> (<i>T. gondii</i>) infection may cause substantial adverse effects on developing fetuses, newborns and also mothers. This study aims to estimate the seroprevalence of <i>T. gondii</i> among rural Bangladeshi pregnant women and determine the risk of a low birth weight (LBW). We followed a longitudinal design where 208 pregnant women were followed until the birth of their infants. Levels of IgG and IgM of <i>T. gondii</i> were assessed using chemiluminescent immunoassay. Modified Poisson regression was used to estimate crude and adjusted associations and multiple regression analysis was performed to understand the confounding and modifying effects of the variables. Thirty-nine (19%) children were born with LBW, among whom 15 (39%) mothers were positive for <i>T. gondii</i> IgG during pregnancy. After adjusting for several confounders and modifiers, pregnant women with <i>T. gondii IgG</i> or IgM seropositivity were significantly associated with LBW of infants (aRR: 2.00, 95% CI: 1.17–3.42). The strength of this association increased after adjusting for maternal education (aRR: 4.88, 95% CI: 1.74–13.69). The final model had an AROC of 0.84 with a sensitivity of 36% and specificity of 97%. Although causality is yet to be established, the study observed an association between <i>T. gondii</i> infection during pregnancy among rural Bangladeshi women and LBW of newborns. |
| first_indexed | 2024-03-09T13:03:11Z |
| format | Article |
| id | doaj.art-d5463ab9c2304eaa9a55d5857d36d7f1 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-09T13:03:11Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-d5463ab9c2304eaa9a55d5857d36d7f12023-11-30T21:52:38ZengMDPI AGPathogens2076-08172022-03-0111333610.3390/pathogens11030336<i>Toxoplasma gondii</i> Infection Is Associated with Low Birth Weight: Findings from an Observational Study among Rural Bangladeshi WomenIrin Parvin0Sumon Kumar Das1Shahnawaz Ahmed2Aminur Rahman3Abu Sadat Mohammad Sayeem Bin Shahid4Lubaba Shahrin5Farzana Afroze6Mst. Mahmuda Ackhter7Tahmina Alam8Yasmin Jahan9Parag Palit10Mohammad Habibur Rahman Sarker11Jui Das12Mohammad Enamul Hoque13Ricardo J. Soares Magalhães14Abdullah Al Mamun15Abu Syed Golam Faruque16Tahmeed Ahmed17Mohammod Jobayer Chisti18International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka 1212, BangladeshMenzies—School of Health Research, Charles Darwin University, Darwin, NT 0811, AustraliaSchool of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, QLD 4067, AustraliaInternational Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka 1212, BangladeshInternational Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka 1212, BangladeshInternational Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka 1212, BangladeshInternational Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka 1212, BangladeshInternational Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka 1212, BangladeshInternational Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka 1212, BangladeshInternational Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka 1212, BangladeshInternational Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka 1212, BangladeshInternational Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka 1212, BangladeshMater Research Institute, The University of Queensland, Brisbane, QLD 4067, AustraliaNHMRC Clinical Trials Centre, The University of Sydney, Sydney, NSW 2006, AustraliaUQ Spatial Epidemiology Laboratory, School of Veterinary Science, The University of Queensland, Gatton, QLD 4343, AustraliaInstitute for Social Science Research, The University of Queensland, Brisbane, QLD 4067, AustraliaInternational Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka 1212, BangladeshInternational Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka 1212, BangladeshInternational Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka 1212, BangladeshGestational <i>Toxoplasma gondii</i> (<i>T. gondii</i>) infection may cause substantial adverse effects on developing fetuses, newborns and also mothers. This study aims to estimate the seroprevalence of <i>T. gondii</i> among rural Bangladeshi pregnant women and determine the risk of a low birth weight (LBW). We followed a longitudinal design where 208 pregnant women were followed until the birth of their infants. Levels of IgG and IgM of <i>T. gondii</i> were assessed using chemiluminescent immunoassay. Modified Poisson regression was used to estimate crude and adjusted associations and multiple regression analysis was performed to understand the confounding and modifying effects of the variables. Thirty-nine (19%) children were born with LBW, among whom 15 (39%) mothers were positive for <i>T. gondii</i> IgG during pregnancy. After adjusting for several confounders and modifiers, pregnant women with <i>T. gondii IgG</i> or IgM seropositivity were significantly associated with LBW of infants (aRR: 2.00, 95% CI: 1.17–3.42). The strength of this association increased after adjusting for maternal education (aRR: 4.88, 95% CI: 1.74–13.69). The final model had an AROC of 0.84 with a sensitivity of 36% and specificity of 97%. Although causality is yet to be established, the study observed an association between <i>T. gondii</i> infection during pregnancy among rural Bangladeshi women and LBW of newborns.https://www.mdpi.com/2076-0817/11/3/336Bangladeshlow birth weightpregnant womenrural<i>Toxoplasma gondii</i><i>T</i>. <i>gondii</i> |
| spellingShingle | Irin Parvin Sumon Kumar Das Shahnawaz Ahmed Aminur Rahman Abu Sadat Mohammad Sayeem Bin Shahid Lubaba Shahrin Farzana Afroze Mst. Mahmuda Ackhter Tahmina Alam Yasmin Jahan Parag Palit Mohammad Habibur Rahman Sarker Jui Das Mohammad Enamul Hoque Ricardo J. Soares Magalhães Abdullah Al Mamun Abu Syed Golam Faruque Tahmeed Ahmed Mohammod Jobayer Chisti <i>Toxoplasma gondii</i> Infection Is Associated with Low Birth Weight: Findings from an Observational Study among Rural Bangladeshi Women Pathogens Bangladesh low birth weight pregnant women rural <i>Toxoplasma gondii</i> <i>T</i>. <i>gondii</i> |
| title | <i>Toxoplasma gondii</i> Infection Is Associated with Low Birth Weight: Findings from an Observational Study among Rural Bangladeshi Women |
| title_full | <i>Toxoplasma gondii</i> Infection Is Associated with Low Birth Weight: Findings from an Observational Study among Rural Bangladeshi Women |
| title_fullStr | <i>Toxoplasma gondii</i> Infection Is Associated with Low Birth Weight: Findings from an Observational Study among Rural Bangladeshi Women |
| title_full_unstemmed | <i>Toxoplasma gondii</i> Infection Is Associated with Low Birth Weight: Findings from an Observational Study among Rural Bangladeshi Women |
| title_short | <i>Toxoplasma gondii</i> Infection Is Associated with Low Birth Weight: Findings from an Observational Study among Rural Bangladeshi Women |
| title_sort | i toxoplasma gondii i infection is associated with low birth weight findings from an observational study among rural bangladeshi women |
| topic | Bangladesh low birth weight pregnant women rural <i>Toxoplasma gondii</i> <i>T</i>. <i>gondii</i> |
| url | https://www.mdpi.com/2076-0817/11/3/336 |
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