P2Y Receptor-Mediated Ca2+ Signaling Increases Human Vascular Endothelial Cell Permeability

P2Y Receptor-Mediated Ca2+ Signaling Increases Human Vascular Endothelial Cell Permeability

We investigated the effects of P2-receptor agonists on cell size, intracellular calcium levels ([Ca2+]i), and permeation of FITC-labeled dextran (FD-4) as well as the relationship between these effects in human umbilical vein endothelial cells (HUVEC). FD-4 concentration, cell size, and [Ca2+]i were...

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Bibliographic Details
Main Authors: Naoko Tanaka, Kumiko Kawasaki, Namie Nejime, Yoko Kubota, Kazuki Nakamura, Masaru Kunitomo, Koichi Takahashi, Michio Hashimoto, Kazumasa Shinozuka
Format: Article
Language:English
Published: Elsevier 2004-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S134786131932434X

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