The Microbiota and the Relationship with Colorectal Cancer: Surgical Complications—A Review
Colorectal cancer (CRC) is one of the most common cancers and represents a major global health burden. While genetics are implicated in a portion of CRC patients, most cases are sporadic. A new possibility of tumor initiation and promotion might be microbiome composition. It was recently shown that...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Gastrointestinal Disorders |
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| Online Access: | https://www.mdpi.com/2624-5647/4/2/8 |
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| author | Alexandru Michire Rodica Anghel Petruta Maria Draghia Mihnea Gabriel Burlacu Teodor Florin Georgescu Dragos Eugen Georgescu Andra-Elena Balcangiu-Stroescu Ileana Adela Vacaroiu Maria Barbu Alexandra Gaube |
| author_facet | Alexandru Michire Rodica Anghel Petruta Maria Draghia Mihnea Gabriel Burlacu Teodor Florin Georgescu Dragos Eugen Georgescu Andra-Elena Balcangiu-Stroescu Ileana Adela Vacaroiu Maria Barbu Alexandra Gaube |
| author_sort | Alexandru Michire |
| collection | DOAJ |
| description | Colorectal cancer (CRC) is one of the most common cancers and represents a major global health burden. While genetics are implicated in a portion of CRC patients, most cases are sporadic. A new possibility of tumor initiation and promotion might be microbiome composition. It was recently shown that bacteria from the gut microbiome might be used as biomarkers for CRC detection, especially <i>Fusobacterium nucleatum, Peptostreoptococcus stomatis, Parvimonas mica, Solobacterium moorei,</i> and <i>Peptostreptococcus anaerobius.</i> Conversely, the healthy gut microbiome is mostly colonized by Bacterioides (<i>Bacterioides fragilis</i>, <i>vulgatus</i>, <i>uniformis</i>), Firmicutes (<i>Clostridium</i> spp., <i>Ruminococcus faecis</i>, <i>Enterococcus faecium</i>), and Actinobacteria (<i>Bifidobacterium bifidum</i>). Some strains of gut bacteria favor tumor promotion through DNA and RNA damage (directly or through interaction with other known food carcinogens) and through local immune inhibition. It is possible that bacteria (e.g., <i>Bacillus polyfermenticus</i>, <i>Alistipes shahii</i>, <i>Lactobacillus casei</i>) exist with protective functions against tumor promotion. Despite current advances in colorectal cancer treatment, especially in the medical oncology and radiotherapy domains, surgery remains the mainstay of curative treatment for colorectal cancer patients, even in the oligometastatic setting. Surgical complications like anastomotic leakage, excessive blood loss, abscess, and abdominal sepsis can reduce 1-year and 5-year overall survival and increase the recurrence rates for these patients; therefore, we reviewed currently published data focusing on the relationship between gut microbiota and postoperative complications for colorectal cancer patients. |
| first_indexed | 2024-03-09T23:45:12Z |
| format | Article |
| id | doaj.art-d547b4cc132745f69dae863722f57f41 |
| institution | Directory Open Access Journal |
| issn | 2624-5647 |
| language | English |
| last_indexed | 2024-03-09T23:45:12Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gastrointestinal Disorders |
| spelling | doaj.art-d547b4cc132745f69dae863722f57f412023-11-23T16:44:53ZengMDPI AGGastrointestinal Disorders2624-56472022-04-0142667610.3390/gidisord4020008The Microbiota and the Relationship with Colorectal Cancer: Surgical Complications—A ReviewAlexandru Michire0Rodica Anghel1Petruta Maria Draghia2Mihnea Gabriel Burlacu3Teodor Florin Georgescu4Dragos Eugen Georgescu5Andra-Elena Balcangiu-Stroescu6Ileana Adela Vacaroiu7Maria Barbu8Alexandra Gaube9Department 8—Radiology, Oncology, Hematology, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, Bulevardul Eroii Sanitari 8, 050474 Bucharest, RomaniaDepartment 8—Radiology, Oncology, Hematology, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, Bulevardul Eroii Sanitari 8, 050474 Bucharest, RomaniaRadiation Therapy Department, “Prof. Dr. Al. Trestioreanu” Oncology Institute, Sos. Fundeni No. 252, 022328 Bucharest, RomaniaRadiation Therapy Department, “Prof. Dr. Al. Trestioreanu” Oncology Institute, Sos. Fundeni No. 252, 022328 Bucharest, RomaniaDepartment 10—General Surgery, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, Bulevardul Eroii Sanitari 8, 050474 Bucharest, RomaniaDepartment 10—General Surgery, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, Bulevardul Eroii Sanitari 8, 050474 Bucharest, RomaniaDepartment 3—Physiology, Faculty of Dental Medicine, “Carol Davila” University of Medicine and Pharmacy, Bulevardul Eroii Sanitari 8, 050474 Bucharest, RomaniaDepartment 3—Nephrology, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, Bulevardul Eroii Sanitari 8, 050474 Bucharest, RomaniaDepartment 8—Radiology, Oncology, Hematology, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, Bulevardul Eroii Sanitari 8, 050474 Bucharest, RomaniaNational Institute of Infectious Diseases “Prof. Dr. Matei Bals”, 021105 Bucharest, RomaniaColorectal cancer (CRC) is one of the most common cancers and represents a major global health burden. While genetics are implicated in a portion of CRC patients, most cases are sporadic. A new possibility of tumor initiation and promotion might be microbiome composition. It was recently shown that bacteria from the gut microbiome might be used as biomarkers for CRC detection, especially <i>Fusobacterium nucleatum, Peptostreoptococcus stomatis, Parvimonas mica, Solobacterium moorei,</i> and <i>Peptostreptococcus anaerobius.</i> Conversely, the healthy gut microbiome is mostly colonized by Bacterioides (<i>Bacterioides fragilis</i>, <i>vulgatus</i>, <i>uniformis</i>), Firmicutes (<i>Clostridium</i> spp., <i>Ruminococcus faecis</i>, <i>Enterococcus faecium</i>), and Actinobacteria (<i>Bifidobacterium bifidum</i>). Some strains of gut bacteria favor tumor promotion through DNA and RNA damage (directly or through interaction with other known food carcinogens) and through local immune inhibition. It is possible that bacteria (e.g., <i>Bacillus polyfermenticus</i>, <i>Alistipes shahii</i>, <i>Lactobacillus casei</i>) exist with protective functions against tumor promotion. Despite current advances in colorectal cancer treatment, especially in the medical oncology and radiotherapy domains, surgery remains the mainstay of curative treatment for colorectal cancer patients, even in the oligometastatic setting. Surgical complications like anastomotic leakage, excessive blood loss, abscess, and abdominal sepsis can reduce 1-year and 5-year overall survival and increase the recurrence rates for these patients; therefore, we reviewed currently published data focusing on the relationship between gut microbiota and postoperative complications for colorectal cancer patients.https://www.mdpi.com/2624-5647/4/2/8colorectal cancermicrobiotaanastomotic leakageinfectious complicationsadhesions |
| spellingShingle | Alexandru Michire Rodica Anghel Petruta Maria Draghia Mihnea Gabriel Burlacu Teodor Florin Georgescu Dragos Eugen Georgescu Andra-Elena Balcangiu-Stroescu Ileana Adela Vacaroiu Maria Barbu Alexandra Gaube The Microbiota and the Relationship with Colorectal Cancer: Surgical Complications—A Review Gastrointestinal Disorders colorectal cancer microbiota anastomotic leakage infectious complications adhesions |
| title | The Microbiota and the Relationship with Colorectal Cancer: Surgical Complications—A Review |
| title_full | The Microbiota and the Relationship with Colorectal Cancer: Surgical Complications—A Review |
| title_fullStr | The Microbiota and the Relationship with Colorectal Cancer: Surgical Complications—A Review |
| title_full_unstemmed | The Microbiota and the Relationship with Colorectal Cancer: Surgical Complications—A Review |
| title_short | The Microbiota and the Relationship with Colorectal Cancer: Surgical Complications—A Review |
| title_sort | microbiota and the relationship with colorectal cancer surgical complications a review |
| topic | colorectal cancer microbiota anastomotic leakage infectious complications adhesions |
| url | https://www.mdpi.com/2624-5647/4/2/8 |
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