Decoding the mechanisms of allostery
A complex interplay between structure, conformational dynamics and pharmacology defines distant regulation of G protein-coupled receptors.
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications Ltd
2023-06-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/88749 |
| _version_ | 1797813404535095296 |
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| author | Saif Khan Cornelius Gati |
| author_facet | Saif Khan Cornelius Gati |
| author_sort | Saif Khan |
| collection | DOAJ |
| description | A complex interplay between structure, conformational dynamics and pharmacology defines distant regulation of G protein-coupled receptors. |
| first_indexed | 2024-03-13T07:52:28Z |
| format | Article |
| id | doaj.art-d549def61ab84cc98ca056f716dbf27d |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-03-13T07:52:28Z |
| publishDate | 2023-06-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-d549def61ab84cc98ca056f716dbf27d2023-06-02T12:07:44ZengeLife Sciences Publications LtdeLife2050-084X2023-06-011210.7554/eLife.88749Decoding the mechanisms of allosterySaif Khan0https://orcid.org/0000-0002-3604-2670Cornelius Gati1https://orcid.org/0000-0003-3693-7009Bridge Institute, USC Michelson Center for Convergent Biosciences, Department of Biological Sciences, University of Southern California, Los Angeles, United StatesBridge Institute, USC Michelson Center for Convergent Biosciences, Department of Biological Sciences, University of Southern California, Los Angeles, United StatesA complex interplay between structure, conformational dynamics and pharmacology defines distant regulation of G protein-coupled receptors.https://elifesciences.org/articles/88749allosterydrug discoverymolecular dynamicsmolecular pharmacologymuscarinic acetylcholine receptorsstructural biology |
| spellingShingle | Saif Khan Cornelius Gati Decoding the mechanisms of allostery eLife allostery drug discovery molecular dynamics molecular pharmacology muscarinic acetylcholine receptors structural biology |
| title | Decoding the mechanisms of allostery |
| title_full | Decoding the mechanisms of allostery |
| title_fullStr | Decoding the mechanisms of allostery |
| title_full_unstemmed | Decoding the mechanisms of allostery |
| title_short | Decoding the mechanisms of allostery |
| title_sort | decoding the mechanisms of allostery |
| topic | allostery drug discovery molecular dynamics molecular pharmacology muscarinic acetylcholine receptors structural biology |
| url | https://elifesciences.org/articles/88749 |
| work_keys_str_mv | AT saifkhan decodingthemechanismsofallostery AT corneliusgati decodingthemechanismsofallostery |