Native and engineered extracellular vesicles for wound healing
Extracellular vesicles (EVs) that act as messengers mediate communication between parent and recipient cells through their contents, including nucleic acids, proteins, and lipids. These endogenous vesicles have emerged as a novel cell-free strategy for the treatment of diseases. EVs can be released...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.1053217/full |
| _version_ | 1811186378568892416 |
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| author | Shengli Lu Liping Lu Yang Liu Yang Liu Zenan Li Yuan Fang Zhizhao Chen Jianda Zhou |
| author_facet | Shengli Lu Liping Lu Yang Liu Yang Liu Zenan Li Yuan Fang Zhizhao Chen Jianda Zhou |
| author_sort | Shengli Lu |
| collection | DOAJ |
| description | Extracellular vesicles (EVs) that act as messengers mediate communication between parent and recipient cells through their contents, including nucleic acids, proteins, and lipids. These endogenous vesicles have emerged as a novel cell-free strategy for the treatment of diseases. EVs can be released by various types of cells with unique biological properties. Recent studies have shown that native EVs are used as therapeutic agents to promote tissue repair by delivering various growth factors and trophic factors including VEGF, EGF, TFN-α, IL-1β, and TGF-β to participate in all physiological processes of wound healing. Furthermore, to improve their specificity, safety, and efficiency for wound healing, the content and surface of EVs can be designed, modified, and engineered. The engineering strategies of EVs are divided into parent cell modification and indirect modification of EVs. The therapeutic potential of current EVs and engineered EVs for wound healing still requires the exploration of their large-scale clinical applications through innovative approaches. Herein, we provide an overview of the current biological knowledge about wound healing and EVs, as well as the application of native EVs in promoting wound healing. We also outline recent advances in engineering EV methodologies to achieve ideal therapeutic potential. Finally, the therapeutic applications of engineered EVs in wound healing are reviewed, and the challenges and prospects for the translation of engineered EVs to clinical applications are discussed. |
| first_indexed | 2024-04-11T13:44:31Z |
| format | Article |
| id | doaj.art-d54aa33b946148e8a4bf1529c35f55c8 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-11T13:44:31Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-d54aa33b946148e8a4bf1529c35f55c82022-12-22T04:21:08ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-12-011010.3389/fbioe.2022.10532171053217Native and engineered extracellular vesicles for wound healingShengli Lu0Liping Lu1Yang Liu2Yang Liu3Zenan Li4Yuan Fang5Zhizhao Chen6Jianda Zhou7Department of Plastic Surgery, The Third Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Pediatrics, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Plastic Surgery, The Third Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Dermatology, Leiden University Medical Center, Leiden, NetherlandDepartment of Plastic Surgery, The Third Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Plastic Surgery, The Third Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Plastic Surgery, The Third Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Plastic Surgery, The Third Xiangya Hospital, Central South University, Changsha, ChinaExtracellular vesicles (EVs) that act as messengers mediate communication between parent and recipient cells through their contents, including nucleic acids, proteins, and lipids. These endogenous vesicles have emerged as a novel cell-free strategy for the treatment of diseases. EVs can be released by various types of cells with unique biological properties. Recent studies have shown that native EVs are used as therapeutic agents to promote tissue repair by delivering various growth factors and trophic factors including VEGF, EGF, TFN-α, IL-1β, and TGF-β to participate in all physiological processes of wound healing. Furthermore, to improve their specificity, safety, and efficiency for wound healing, the content and surface of EVs can be designed, modified, and engineered. The engineering strategies of EVs are divided into parent cell modification and indirect modification of EVs. The therapeutic potential of current EVs and engineered EVs for wound healing still requires the exploration of their large-scale clinical applications through innovative approaches. Herein, we provide an overview of the current biological knowledge about wound healing and EVs, as well as the application of native EVs in promoting wound healing. We also outline recent advances in engineering EV methodologies to achieve ideal therapeutic potential. Finally, the therapeutic applications of engineered EVs in wound healing are reviewed, and the challenges and prospects for the translation of engineered EVs to clinical applications are discussed.https://www.frontiersin.org/articles/10.3389/fbioe.2022.1053217/fullwound healingextracellular vesiclesexosomeengineered extracellular vesicleschronic wound |
| spellingShingle | Shengli Lu Liping Lu Yang Liu Yang Liu Zenan Li Yuan Fang Zhizhao Chen Jianda Zhou Native and engineered extracellular vesicles for wound healing Frontiers in Bioengineering and Biotechnology wound healing extracellular vesicles exosome engineered extracellular vesicles chronic wound |
| title | Native and engineered extracellular vesicles for wound healing |
| title_full | Native and engineered extracellular vesicles for wound healing |
| title_fullStr | Native and engineered extracellular vesicles for wound healing |
| title_full_unstemmed | Native and engineered extracellular vesicles for wound healing |
| title_short | Native and engineered extracellular vesicles for wound healing |
| title_sort | native and engineered extracellular vesicles for wound healing |
| topic | wound healing extracellular vesicles exosome engineered extracellular vesicles chronic wound |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.1053217/full |
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