Level of Potassium Is Associated with Saturated Fatty Acids in Cell Membranes and Influences the Activation of the 9 and 13 HODE and 5 HETE Synthesis Pathways in PCOS
Potassium helps to maintain the water–electrolyte and acid–base balance. There is little research on the relationship between plasma fatty acids (FAs), inflammatory mediators and red blood cell potassium levels in women with polycystic ovary syndrome (PCOS). This study included 38 Caucasian women wi...
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MDPI AG
2022-09-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/9/2244 |
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| author | Małgorzata Szczuko Kamila Pokorska-Niewiada Lidia Kwiatkowska Jolanta Nawrocka-Rutkowska Iwona Szydłowska Maciej Ziętek |
| author_facet | Małgorzata Szczuko Kamila Pokorska-Niewiada Lidia Kwiatkowska Jolanta Nawrocka-Rutkowska Iwona Szydłowska Maciej Ziętek |
| author_sort | Małgorzata Szczuko |
| collection | DOAJ |
| description | Potassium helps to maintain the water–electrolyte and acid–base balance. There is little research on the relationship between plasma fatty acids (FAs), inflammatory mediators and red blood cell potassium levels in women with polycystic ovary syndrome (PCOS). This study included 38 Caucasian women with PCOS. Potassium in the erythrocytes was determined by inductively coupled atomic plasma emission spectrometry. The FAs were analysed with gas chromatography, and liquid chromatography was used to separate the eicosanoids. The relationships between the potassium content and the amounts of fatty acids, as well as potassium and arachidonic acid (AAs) derivatives, were analysed. Significant negative correlations were found with, among others, pentadecanoic acid, palmitic acid, stearic acid and arachidic acid, whereas a positive correlation was found with neuronic acid. Positive correlations were observed with 9, 13 HODE (derivatives synthetized from linolenic acid) and 5 oxo ETE and 5 HETE (from 5 LOX pathway). Saturated fatty acids reduce the influx of potassium into the cell by destabilizing the pH of the cytosol, and thus exacerbating the inflammatory response through the activation of the AA cascade. Therefore, improving the flow of potassium inside the cell is important in the treatment of patients. |
| first_indexed | 2024-03-10T00:38:44Z |
| format | Article |
| id | doaj.art-d54c8e977de04e68b2654f10b2dd5728 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T00:38:44Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-d54c8e977de04e68b2654f10b2dd57282023-11-23T15:11:34ZengMDPI AGBiomedicines2227-90592022-09-01109224410.3390/biomedicines10092244Level of Potassium Is Associated with Saturated Fatty Acids in Cell Membranes and Influences the Activation of the 9 and 13 HODE and 5 HETE Synthesis Pathways in PCOSMałgorzata Szczuko0Kamila Pokorska-Niewiada1Lidia Kwiatkowska2Jolanta Nawrocka-Rutkowska3Iwona Szydłowska4Maciej Ziętek5Department of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 71-460 Szczein, PolandDepartment of Toxicology, Dairy Technology and Food Storage, West Pomeranian University of Technology in Szczecin, 71-374 Szczecin, PolandDepartment of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 71-460 Szczein, PolandDepartment of Gynecology, Endocrinology and Gynecological Oncology, Pomeranian Medical University Szczecin, 71-252 Szczecin, PolandDepartment of Gynecology, Endocrinology and Gynecological Oncology, Pomeranian Medical University Szczecin, 71-252 Szczecin, PolandDepartment of Perinatology, Obstetrics and Gynecology, Pomeranian Medical University in Szczecin, 72-009 Police, PolandPotassium helps to maintain the water–electrolyte and acid–base balance. There is little research on the relationship between plasma fatty acids (FAs), inflammatory mediators and red blood cell potassium levels in women with polycystic ovary syndrome (PCOS). This study included 38 Caucasian women with PCOS. Potassium in the erythrocytes was determined by inductively coupled atomic plasma emission spectrometry. The FAs were analysed with gas chromatography, and liquid chromatography was used to separate the eicosanoids. The relationships between the potassium content and the amounts of fatty acids, as well as potassium and arachidonic acid (AAs) derivatives, were analysed. Significant negative correlations were found with, among others, pentadecanoic acid, palmitic acid, stearic acid and arachidic acid, whereas a positive correlation was found with neuronic acid. Positive correlations were observed with 9, 13 HODE (derivatives synthetized from linolenic acid) and 5 oxo ETE and 5 HETE (from 5 LOX pathway). Saturated fatty acids reduce the influx of potassium into the cell by destabilizing the pH of the cytosol, and thus exacerbating the inflammatory response through the activation of the AA cascade. Therefore, improving the flow of potassium inside the cell is important in the treatment of patients.https://www.mdpi.com/2227-9059/10/9/2244erythrocytespotassiumHODEHETEarachidonic acid derivatives (AA) |
| spellingShingle | Małgorzata Szczuko Kamila Pokorska-Niewiada Lidia Kwiatkowska Jolanta Nawrocka-Rutkowska Iwona Szydłowska Maciej Ziętek Level of Potassium Is Associated with Saturated Fatty Acids in Cell Membranes and Influences the Activation of the 9 and 13 HODE and 5 HETE Synthesis Pathways in PCOS Biomedicines erythrocytes potassium HODE HETE arachidonic acid derivatives (AA) |
| title | Level of Potassium Is Associated with Saturated Fatty Acids in Cell Membranes and Influences the Activation of the 9 and 13 HODE and 5 HETE Synthesis Pathways in PCOS |
| title_full | Level of Potassium Is Associated with Saturated Fatty Acids in Cell Membranes and Influences the Activation of the 9 and 13 HODE and 5 HETE Synthesis Pathways in PCOS |
| title_fullStr | Level of Potassium Is Associated with Saturated Fatty Acids in Cell Membranes and Influences the Activation of the 9 and 13 HODE and 5 HETE Synthesis Pathways in PCOS |
| title_full_unstemmed | Level of Potassium Is Associated with Saturated Fatty Acids in Cell Membranes and Influences the Activation of the 9 and 13 HODE and 5 HETE Synthesis Pathways in PCOS |
| title_short | Level of Potassium Is Associated with Saturated Fatty Acids in Cell Membranes and Influences the Activation of the 9 and 13 HODE and 5 HETE Synthesis Pathways in PCOS |
| title_sort | level of potassium is associated with saturated fatty acids in cell membranes and influences the activation of the 9 and 13 hode and 5 hete synthesis pathways in pcos |
| topic | erythrocytes potassium HODE HETE arachidonic acid derivatives (AA) |
| url | https://www.mdpi.com/2227-9059/10/9/2244 |
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