Development of chitosan nanoparticles for anticancer drug delivery systems
Chitosan is a natural polymer that is often used in nanotechnology because it has such useful properties as biodegradability and biocompatibility. Chitosan has many benefits, but they are outweighed by drawbacks such insolubility, aggregation at physiological pH, and insufficient cargo release in th...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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EDP Sciences
2023-01-01
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| Series: | MATEC Web of Conferences |
| Online Access: | https://www.matec-conferences.org/articles/matecconf/pdf/2023/03/matecconf_amefp23_01001.pdf |
| _version_ | 1797843670624370688 |
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| author | Fatkullina Larisa Shmelev Mikhail Silantev Vladimir Kumeiko Vadim |
| author_facet | Fatkullina Larisa Shmelev Mikhail Silantev Vladimir Kumeiko Vadim |
| author_sort | Fatkullina Larisa |
| collection | DOAJ |
| description | Chitosan is a natural polymer that is often used in nanotechnology because it has such useful properties as biodegradability and biocompatibility. Chitosan has many benefits, but they are outweighed by drawbacks such insolubility, aggregation at physiological pH, and insufficient cargo release in the cytosol. In order to obtain chitosan nanoparticles that can be used as drug delivery systems, we optimized the synthesis technology by selecting MES buffer pH 6.3 and using a BSA coating step to reduce nanoparticle aggregation. Deposition of the chemotherapeutic agent etoposide in chitosan nanoparticles has been proven and confirmed by IR spectra, although future experiments are needed to tune conditions for stronger interactions. The chitosan nanoparticles that we have obtained can become suitable nanomaterials for biomedical applications as promising carriers for drug delivery. |
| first_indexed | 2024-04-09T17:09:08Z |
| format | Article |
| id | doaj.art-d54e894d970346b5a55a0451fef5c17e |
| institution | Directory Open Access Journal |
| issn | 2261-236X |
| language | English |
| last_indexed | 2024-04-09T17:09:08Z |
| publishDate | 2023-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | MATEC Web of Conferences |
| spelling | doaj.art-d54e894d970346b5a55a0451fef5c17e2023-04-20T08:28:00ZengEDP SciencesMATEC Web of Conferences2261-236X2023-01-013760100110.1051/matecconf/202337601001matecconf_amefp23_01001Development of chitosan nanoparticles for anticancer drug delivery systemsFatkullina Larisa0Shmelev Mikhail1Silantev Vladimir2Kumeiko Vadim3Institute of Life Sciences and Biomedicine, Far Eastern Federal UniversityInstitute of Life Sciences and Biomedicine, Far Eastern Federal UniversityInstitute of Life Sciences and Biomedicine, Far Eastern Federal UniversityInstitute of Life Sciences and Biomedicine, Far Eastern Federal UniversityChitosan is a natural polymer that is often used in nanotechnology because it has such useful properties as biodegradability and biocompatibility. Chitosan has many benefits, but they are outweighed by drawbacks such insolubility, aggregation at physiological pH, and insufficient cargo release in the cytosol. In order to obtain chitosan nanoparticles that can be used as drug delivery systems, we optimized the synthesis technology by selecting MES buffer pH 6.3 and using a BSA coating step to reduce nanoparticle aggregation. Deposition of the chemotherapeutic agent etoposide in chitosan nanoparticles has been proven and confirmed by IR spectra, although future experiments are needed to tune conditions for stronger interactions. The chitosan nanoparticles that we have obtained can become suitable nanomaterials for biomedical applications as promising carriers for drug delivery.https://www.matec-conferences.org/articles/matecconf/pdf/2023/03/matecconf_amefp23_01001.pdf |
| spellingShingle | Fatkullina Larisa Shmelev Mikhail Silantev Vladimir Kumeiko Vadim Development of chitosan nanoparticles for anticancer drug delivery systems MATEC Web of Conferences |
| title | Development of chitosan nanoparticles for anticancer drug delivery systems |
| title_full | Development of chitosan nanoparticles for anticancer drug delivery systems |
| title_fullStr | Development of chitosan nanoparticles for anticancer drug delivery systems |
| title_full_unstemmed | Development of chitosan nanoparticles for anticancer drug delivery systems |
| title_short | Development of chitosan nanoparticles for anticancer drug delivery systems |
| title_sort | development of chitosan nanoparticles for anticancer drug delivery systems |
| url | https://www.matec-conferences.org/articles/matecconf/pdf/2023/03/matecconf_amefp23_01001.pdf |
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