Brain-Derived Neurotrophic Factor in Pediatric Acquired Brain Injury and Recovery
We review emerging preclinical and clinical evidence regarding brain-derived neurotrophic factor (BDNF) protein, genotype, and DNA methylation (DNAm) as biomarkers of outcomes in three important etiologies of pediatric acquired brain injury (ABI), traumatic brain injury, global cerebral ischemia, an...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-02-01
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| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/14/2/191 |
| _version_ | 1797298784303054848 |
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| author | Amery Treble-Barna Bailey A. Petersen Zachary Stec Yvette P. Conley Ericka L. Fink Patrick M. Kochanek |
| author_facet | Amery Treble-Barna Bailey A. Petersen Zachary Stec Yvette P. Conley Ericka L. Fink Patrick M. Kochanek |
| author_sort | Amery Treble-Barna |
| collection | DOAJ |
| description | We review emerging preclinical and clinical evidence regarding brain-derived neurotrophic factor (BDNF) protein, genotype, and DNA methylation (DNAm) as biomarkers of outcomes in three important etiologies of pediatric acquired brain injury (ABI), traumatic brain injury, global cerebral ischemia, and stroke. We also summarize evidence suggesting that BDNF is (1) involved in the biological embedding of the psychosocial environment, (2) responsive to rehabilitative therapies, and (3) potentially modifiable. BDNF’s unique potential as a biomarker of neuroplasticity and neural repair that is reflective of and responsive to both pre- and post-injury environmental influences separates it from traditional protein biomarkers of structural brain injury with exciting potential to advance pediatric ABI management by increasing the accuracy of prognostic tools and informing clinical decision making through the monitoring of therapeutic effects. |
| first_indexed | 2024-03-07T22:41:04Z |
| format | Article |
| id | doaj.art-d5505fee8ec74c17a4ce5fd45d28a574 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-07T22:41:04Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-d5505fee8ec74c17a4ce5fd45d28a5742024-02-23T15:09:20ZengMDPI AGBiomolecules2218-273X2024-02-0114219110.3390/biom14020191Brain-Derived Neurotrophic Factor in Pediatric Acquired Brain Injury and RecoveryAmery Treble-Barna0Bailey A. Petersen1Zachary Stec2Yvette P. Conley3Ericka L. Fink4Patrick M. Kochanek5Department of Physical Medicine & Rehabilitation, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USADepartment of Physical Medicine & Rehabilitation, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USADepartment of Physical Medicine & Rehabilitation, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USADepartment of Health Promotion & Development, University of Pittsburgh School of Nursing, Pittsburgh, PA 15213, USASafar Center for Resuscitation Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USASafar Center for Resuscitation Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USAWe review emerging preclinical and clinical evidence regarding brain-derived neurotrophic factor (BDNF) protein, genotype, and DNA methylation (DNAm) as biomarkers of outcomes in three important etiologies of pediatric acquired brain injury (ABI), traumatic brain injury, global cerebral ischemia, and stroke. We also summarize evidence suggesting that BDNF is (1) involved in the biological embedding of the psychosocial environment, (2) responsive to rehabilitative therapies, and (3) potentially modifiable. BDNF’s unique potential as a biomarker of neuroplasticity and neural repair that is reflective of and responsive to both pre- and post-injury environmental influences separates it from traditional protein biomarkers of structural brain injury with exciting potential to advance pediatric ABI management by increasing the accuracy of prognostic tools and informing clinical decision making through the monitoring of therapeutic effects.https://www.mdpi.com/2218-273X/14/2/191pediatric acquired brain injurybiomarkersrecoverybrain-derived neurotrophic factor |
| spellingShingle | Amery Treble-Barna Bailey A. Petersen Zachary Stec Yvette P. Conley Ericka L. Fink Patrick M. Kochanek Brain-Derived Neurotrophic Factor in Pediatric Acquired Brain Injury and Recovery Biomolecules pediatric acquired brain injury biomarkers recovery brain-derived neurotrophic factor |
| title | Brain-Derived Neurotrophic Factor in Pediatric Acquired Brain Injury and Recovery |
| title_full | Brain-Derived Neurotrophic Factor in Pediatric Acquired Brain Injury and Recovery |
| title_fullStr | Brain-Derived Neurotrophic Factor in Pediatric Acquired Brain Injury and Recovery |
| title_full_unstemmed | Brain-Derived Neurotrophic Factor in Pediatric Acquired Brain Injury and Recovery |
| title_short | Brain-Derived Neurotrophic Factor in Pediatric Acquired Brain Injury and Recovery |
| title_sort | brain derived neurotrophic factor in pediatric acquired brain injury and recovery |
| topic | pediatric acquired brain injury biomarkers recovery brain-derived neurotrophic factor |
| url | https://www.mdpi.com/2218-273X/14/2/191 |
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