A new type of DNA phosphorothioation-based antiviral system in archaea
The prokaryote defence system Dnd relies on phosphorothioation (PT) of DNA backbone to distinguish between self and non-self DNA. Here, Xiong et al. describe a previously uncharacterized PT-based antiviral system that is independent of the canonical Dnd and is widespread in Archaea and Bacteria.
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2019-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-09390-9 |
| _version_ | 1819126368304103424 |
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| author | Lei Xiong Siyi Liu Si Chen Yao Xiao Bochen Zhu Yali Gao Yujing Zhang Beibei Chen Jie Luo Zixin Deng Xiangdong Chen Lianrong Wang Shi Chen |
| author_facet | Lei Xiong Siyi Liu Si Chen Yao Xiao Bochen Zhu Yali Gao Yujing Zhang Beibei Chen Jie Luo Zixin Deng Xiangdong Chen Lianrong Wang Shi Chen |
| author_sort | Lei Xiong |
| collection | DOAJ |
| description | The prokaryote defence system Dnd relies on phosphorothioation (PT) of DNA backbone to distinguish between self and non-self DNA. Here, Xiong et al. describe a previously uncharacterized PT-based antiviral system that is independent of the canonical Dnd and is widespread in Archaea and Bacteria. |
| first_indexed | 2024-12-22T07:54:55Z |
| format | Article |
| id | doaj.art-d5520ef95b4f42e68fb602a3ec748976 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-22T07:54:55Z |
| publishDate | 2019-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-d5520ef95b4f42e68fb602a3ec7489762022-12-21T18:33:23ZengNature PortfolioNature Communications2041-17232019-04-0110111110.1038/s41467-019-09390-9A new type of DNA phosphorothioation-based antiviral system in archaeaLei Xiong0Siyi Liu1Si Chen2Yao Xiao3Bochen Zhu4Yali Gao5Yujing Zhang6Beibei Chen7Jie Luo8Zixin Deng9Xiangdong Chen10Lianrong Wang11Shi Chen12Key Laboratory of Combinatorial Biosynthesis and Drug Discovery Ministry of Education, School of Pharmaceutical Sciences, Wuhan UniversityKey Laboratory of Combinatorial Biosynthesis and Drug Discovery Ministry of Education, School of Pharmaceutical Sciences, Wuhan UniversitySchool of Biology and Pharmaceutical Engineering, Wuhan Polytechnic UniversityKey Laboratory of Combinatorial Biosynthesis and Drug Discovery Ministry of Education, School of Pharmaceutical Sciences, Wuhan UniversityKey Laboratory of Combinatorial Biosynthesis and Drug Discovery Ministry of Education, School of Pharmaceutical Sciences, Wuhan UniversityKey Laboratory of Combinatorial Biosynthesis and Drug Discovery Ministry of Education, School of Pharmaceutical Sciences, Wuhan UniversityKey Laboratory of Combinatorial Biosynthesis and Drug Discovery Ministry of Education, School of Pharmaceutical Sciences, Wuhan UniversityCollege of Life Sciences, Wuhan UniversityTaihe Hospital, Hubei University of MedicineKey Laboratory of Combinatorial Biosynthesis and Drug Discovery Ministry of Education, School of Pharmaceutical Sciences, Wuhan UniversityCollege of Life Sciences, Wuhan UniversityKey Laboratory of Combinatorial Biosynthesis and Drug Discovery Ministry of Education, School of Pharmaceutical Sciences, Wuhan UniversityKey Laboratory of Combinatorial Biosynthesis and Drug Discovery Ministry of Education, School of Pharmaceutical Sciences, Wuhan UniversityThe prokaryote defence system Dnd relies on phosphorothioation (PT) of DNA backbone to distinguish between self and non-self DNA. Here, Xiong et al. describe a previously uncharacterized PT-based antiviral system that is independent of the canonical Dnd and is widespread in Archaea and Bacteria.https://doi.org/10.1038/s41467-019-09390-9 |
| spellingShingle | Lei Xiong Siyi Liu Si Chen Yao Xiao Bochen Zhu Yali Gao Yujing Zhang Beibei Chen Jie Luo Zixin Deng Xiangdong Chen Lianrong Wang Shi Chen A new type of DNA phosphorothioation-based antiviral system in archaea Nature Communications |
| title | A new type of DNA phosphorothioation-based antiviral system in archaea |
| title_full | A new type of DNA phosphorothioation-based antiviral system in archaea |
| title_fullStr | A new type of DNA phosphorothioation-based antiviral system in archaea |
| title_full_unstemmed | A new type of DNA phosphorothioation-based antiviral system in archaea |
| title_short | A new type of DNA phosphorothioation-based antiviral system in archaea |
| title_sort | new type of dna phosphorothioation based antiviral system in archaea |
| url | https://doi.org/10.1038/s41467-019-09390-9 |
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