Retracted: The lncRNA SNHG5‐mediated miR‐205‐5p downregulation contributes to the progression of clear cell renal cell carcinoma by targeting ZEB1
ABSTRACT Recent findings have unraveled the critical functions of the long noncoding RNA (lncRNA) SNHG5 in human malignancies. Nevertheless, the role and mechanism of SNHG5 in clear cell renal cell carcinoma (ccRCC) are still elusive. In our study, substantially higher abundance of SNHG5 was observe...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-06-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.3052 |
| _version_ | 1811214749813178368 |
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| author | Wei Xiang Lei Lv Gaofeng Zhou Wei Wu Jingdong Yuan Chuanhua Zhang Guosong Jiang |
| author_facet | Wei Xiang Lei Lv Gaofeng Zhou Wei Wu Jingdong Yuan Chuanhua Zhang Guosong Jiang |
| author_sort | Wei Xiang |
| collection | DOAJ |
| description | ABSTRACT Recent findings have unraveled the critical functions of the long noncoding RNA (lncRNA) SNHG5 in human malignancies. Nevertheless, the role and mechanism of SNHG5 in clear cell renal cell carcinoma (ccRCC) are still elusive. In our study, substantially higher abundance of SNHG5 was observed in ccRCC specimens and cell lines, and increased SNHG5 expression was intimately correlated with tumor size, tumor‐node‐metastasis (TNM) stage, lymph node invasion, and distant metastases in patients with ccRCC. SNHG5 knockdown obviously suppressed the proliferative, migratory, and invasive capabilities of ccRCC cells, whereas SNHG5 overexpression induced the opposite effects. Mechanistically, SNHG5 activated the transcription of ZEB1, which exerts a pivotal role in modulation of epithelia‐mesenchymal transition (EMT) and tumor metastasis. SNHG5 was then shown to act as an endogenous sponge for miR‐205‐5p, which targets ZEB1 in ccRCC. Moreover rescue experiments revealed that SNHG5 promotes ccRCC cell proliferation, migration, and invasion in a miR‐205‐5p‐dependent manner. Additionally, in vivo assays further indicated that overexpression or silencing of SNHG5 in ccRCC cells promoted or suppressed the tumorigenesis and metastasis, respectively. Altogether, the present data provide the first evidence that the lncRNA SNHG5 has an oncogenic role in ccRCC through the SNHG5/miR‐205‐5p/ZEB1 signaling axis and represents a novel potential therapeutic regimen against ccRCC. |
| first_indexed | 2024-04-12T06:09:55Z |
| format | Article |
| id | doaj.art-d5526173ea0142119fa9a2fa0e860db4 |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-04-12T06:09:55Z |
| publishDate | 2020-06-01 |
| publisher | Wiley |
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| series | Cancer Medicine |
| spelling | doaj.art-d5526173ea0142119fa9a2fa0e860db42022-12-22T03:44:45ZengWileyCancer Medicine2045-76342020-06-019124251426410.1002/cam4.3052Retracted: The lncRNA SNHG5‐mediated miR‐205‐5p downregulation contributes to the progression of clear cell renal cell carcinoma by targeting ZEB1Wei Xiang0Lei Lv1Gaofeng Zhou2Wei Wu3Jingdong Yuan4Chuanhua Zhang5Guosong Jiang6Department of Urology Wuhan No. 1 Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan ChinaDepartment of Urology Wuhan No. 1 Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan ChinaDepartment of Urology Wuhan No. 1 Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan ChinaDepartment of Urology Wuhan No. 1 Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan ChinaDepartment of Urology Wuhan No. 1 Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan ChinaDepartment of Urology Wuhan No. 1 Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan ChinaDepartment of Urology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan ChinaABSTRACT Recent findings have unraveled the critical functions of the long noncoding RNA (lncRNA) SNHG5 in human malignancies. Nevertheless, the role and mechanism of SNHG5 in clear cell renal cell carcinoma (ccRCC) are still elusive. In our study, substantially higher abundance of SNHG5 was observed in ccRCC specimens and cell lines, and increased SNHG5 expression was intimately correlated with tumor size, tumor‐node‐metastasis (TNM) stage, lymph node invasion, and distant metastases in patients with ccRCC. SNHG5 knockdown obviously suppressed the proliferative, migratory, and invasive capabilities of ccRCC cells, whereas SNHG5 overexpression induced the opposite effects. Mechanistically, SNHG5 activated the transcription of ZEB1, which exerts a pivotal role in modulation of epithelia‐mesenchymal transition (EMT) and tumor metastasis. SNHG5 was then shown to act as an endogenous sponge for miR‐205‐5p, which targets ZEB1 in ccRCC. Moreover rescue experiments revealed that SNHG5 promotes ccRCC cell proliferation, migration, and invasion in a miR‐205‐5p‐dependent manner. Additionally, in vivo assays further indicated that overexpression or silencing of SNHG5 in ccRCC cells promoted or suppressed the tumorigenesis and metastasis, respectively. Altogether, the present data provide the first evidence that the lncRNA SNHG5 has an oncogenic role in ccRCC through the SNHG5/miR‐205‐5p/ZEB1 signaling axis and represents a novel potential therapeutic regimen against ccRCC.https://doi.org/10.1002/cam4.3052ccRCC,non‐coding RNAsceRNA,ZEB1,miR‐205‐5pSNHG5 |
| spellingShingle | Wei Xiang Lei Lv Gaofeng Zhou Wei Wu Jingdong Yuan Chuanhua Zhang Guosong Jiang Retracted: The lncRNA SNHG5‐mediated miR‐205‐5p downregulation contributes to the progression of clear cell renal cell carcinoma by targeting ZEB1 Cancer Medicine ccRCC,non‐coding RNAs ceRNA,ZEB1,miR‐205‐5p SNHG5 |
| title | Retracted: The lncRNA SNHG5‐mediated miR‐205‐5p downregulation contributes to the progression of clear cell renal cell carcinoma by targeting ZEB1 |
| title_full | Retracted: The lncRNA SNHG5‐mediated miR‐205‐5p downregulation contributes to the progression of clear cell renal cell carcinoma by targeting ZEB1 |
| title_fullStr | Retracted: The lncRNA SNHG5‐mediated miR‐205‐5p downregulation contributes to the progression of clear cell renal cell carcinoma by targeting ZEB1 |
| title_full_unstemmed | Retracted: The lncRNA SNHG5‐mediated miR‐205‐5p downregulation contributes to the progression of clear cell renal cell carcinoma by targeting ZEB1 |
| title_short | Retracted: The lncRNA SNHG5‐mediated miR‐205‐5p downregulation contributes to the progression of clear cell renal cell carcinoma by targeting ZEB1 |
| title_sort | retracted the lncrna snhg5 mediated mir 205 5p downregulation contributes to the progression of clear cell renal cell carcinoma by targeting zeb1 |
| topic | ccRCC,non‐coding RNAs ceRNA,ZEB1,miR‐205‐5p SNHG5 |
| url | https://doi.org/10.1002/cam4.3052 |
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