A Nitro Functionalized MOF with Multi-Enzyme Mimetic Activities for the Colorimetric Sensing of Glucose at Neutral pH
Benefiting from the advantages like large surface area, flexible constitution, and diverse structure, metal-organic frameworks (MOFs) have been one of the most ideal candidates for nanozymes. In this study, a nitro-functionalized MOF, namely NO<sub>2</sub>-MIL-53(Cu), was synthesized. Mu...
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MDPI AG
2023-07-01
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| Online Access: | https://www.mdpi.com/1424-8220/23/14/6277 |
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| author | Ya Wang Yuanhua Wei Siqi Li Guang Hu |
| author_facet | Ya Wang Yuanhua Wei Siqi Li Guang Hu |
| author_sort | Ya Wang |
| collection | DOAJ |
| description | Benefiting from the advantages like large surface area, flexible constitution, and diverse structure, metal-organic frameworks (MOFs) have been one of the most ideal candidates for nanozymes. In this study, a nitro-functionalized MOF, namely NO<sub>2</sub>-MIL-53(Cu), was synthesized. Multi-enzyme mimetic activities were discovered on this MOF, including peroxidase-like, oxidase-like, and laccase-like activity. Compared to the non-functional counterpart (MIL-53(Cu)), NO<sub>2</sub>-MIL-53(Cu) displayed superior enzyme mimetic activities, indicating a positive role of the nitro group in the MOF. Subsequently, the effects of reaction conditions on enzyme mimetic activities were investigated. Remarkably, NO<sub>2</sub>-MIL-53(Cu) exhibited excellent peroxidase-like activity even at neutral pH. Based on this finding, a simple colorimetric sensing platform was developed for the detection of H<sub>2</sub>O<sub>2</sub> and glucose, respectively. The detection liner range for H<sub>2</sub>O<sub>2</sub> is 1–800 μM with a detection limit of 0.69 μM. The detection liner range for glucose is linear range 0.5–300 μM with a detection limit of 2.6 μM. Therefore, this work not only provides an applicable colorimetric platform for glucose detection in a physiological environment, but also offers guidance for the rational design of efficient nanozymes with multi-enzyme mimetic activities. |
| first_indexed | 2024-03-11T00:41:26Z |
| format | Article |
| id | doaj.art-d55426878f124c109567b08623e48e89 |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-03-11T00:41:26Z |
| publishDate | 2023-07-01 |
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| spelling | doaj.art-d55426878f124c109567b08623e48e892023-11-18T21:15:27ZengMDPI AGSensors1424-82202023-07-012314627710.3390/s23146277A Nitro Functionalized MOF with Multi-Enzyme Mimetic Activities for the Colorimetric Sensing of Glucose at Neutral pHYa Wang0Yuanhua Wei1Siqi Li2Guang Hu3Chongqing Key Laboratory of Medicinal Chemistry and Molecular Pharmacology, Chongqing University of Technology, Chongqing 400050, ChinaChongqing Key Laboratory of Medicinal Chemistry and Molecular Pharmacology, Chongqing University of Technology, Chongqing 400050, ChinaChongqing Key Laboratory of Medicinal Chemistry and Molecular Pharmacology, Chongqing University of Technology, Chongqing 400050, ChinaChongqing Key Laboratory of Medicinal Chemistry and Molecular Pharmacology, Chongqing University of Technology, Chongqing 400050, ChinaBenefiting from the advantages like large surface area, flexible constitution, and diverse structure, metal-organic frameworks (MOFs) have been one of the most ideal candidates for nanozymes. In this study, a nitro-functionalized MOF, namely NO<sub>2</sub>-MIL-53(Cu), was synthesized. Multi-enzyme mimetic activities were discovered on this MOF, including peroxidase-like, oxidase-like, and laccase-like activity. Compared to the non-functional counterpart (MIL-53(Cu)), NO<sub>2</sub>-MIL-53(Cu) displayed superior enzyme mimetic activities, indicating a positive role of the nitro group in the MOF. Subsequently, the effects of reaction conditions on enzyme mimetic activities were investigated. Remarkably, NO<sub>2</sub>-MIL-53(Cu) exhibited excellent peroxidase-like activity even at neutral pH. Based on this finding, a simple colorimetric sensing platform was developed for the detection of H<sub>2</sub>O<sub>2</sub> and glucose, respectively. The detection liner range for H<sub>2</sub>O<sub>2</sub> is 1–800 μM with a detection limit of 0.69 μM. The detection liner range for glucose is linear range 0.5–300 μM with a detection limit of 2.6 μM. Therefore, this work not only provides an applicable colorimetric platform for glucose detection in a physiological environment, but also offers guidance for the rational design of efficient nanozymes with multi-enzyme mimetic activities.https://www.mdpi.com/1424-8220/23/14/6277nanozymemetal-organic frameworksmulti-enzyme mimeticsglucosecolorimetric sensor |
| spellingShingle | Ya Wang Yuanhua Wei Siqi Li Guang Hu A Nitro Functionalized MOF with Multi-Enzyme Mimetic Activities for the Colorimetric Sensing of Glucose at Neutral pH Sensors nanozyme metal-organic frameworks multi-enzyme mimetics glucose colorimetric sensor |
| title | A Nitro Functionalized MOF with Multi-Enzyme Mimetic Activities for the Colorimetric Sensing of Glucose at Neutral pH |
| title_full | A Nitro Functionalized MOF with Multi-Enzyme Mimetic Activities for the Colorimetric Sensing of Glucose at Neutral pH |
| title_fullStr | A Nitro Functionalized MOF with Multi-Enzyme Mimetic Activities for the Colorimetric Sensing of Glucose at Neutral pH |
| title_full_unstemmed | A Nitro Functionalized MOF with Multi-Enzyme Mimetic Activities for the Colorimetric Sensing of Glucose at Neutral pH |
| title_short | A Nitro Functionalized MOF with Multi-Enzyme Mimetic Activities for the Colorimetric Sensing of Glucose at Neutral pH |
| title_sort | nitro functionalized mof with multi enzyme mimetic activities for the colorimetric sensing of glucose at neutral ph |
| topic | nanozyme metal-organic frameworks multi-enzyme mimetics glucose colorimetric sensor |
| url | https://www.mdpi.com/1424-8220/23/14/6277 |
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