Factors Related to Increasing Prevalence of Resistance to Ciprofloxacin and Other Antimicrobial Drugs in Neisseria gonorrhoeae, United States
Using data from the Gonococcal Isolate Surveillance Project, we studied changes in ciprofloxacin resistance in Neisseria gonorrhoeae isolates in the United States during 2002–2007. Compared with prevalence in heterosexual men, prevalence of ciprofloxacin-resistant N. gonorrhoeae infections showed a...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Centers for Disease Control and Prevention
2012-08-01
|
| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/18/8/11-1202_article |
| _version_ | 1811321631757303808 |
|---|---|
| author | Edward Goldstein Robert D. Kirkcaldy David Reshef Stuart Berman Hillard Weinstock Pardis Sabeti Carlos Del Rio Geraldine Hall Edward W. Hook Marc Lipsitch |
| author_facet | Edward Goldstein Robert D. Kirkcaldy David Reshef Stuart Berman Hillard Weinstock Pardis Sabeti Carlos Del Rio Geraldine Hall Edward W. Hook Marc Lipsitch |
| author_sort | Edward Goldstein |
| collection | DOAJ |
| description | Using data from the Gonococcal Isolate Surveillance Project, we studied changes in ciprofloxacin resistance in Neisseria gonorrhoeae isolates in the United States during 2002–2007. Compared with prevalence in heterosexual men, prevalence of ciprofloxacin-resistant N. gonorrhoeae infections showed a more pronounced increase in men who have sex with men (MSM), particularly through an increase in prevalence of strains also resistant to tetracycline and penicillin. Moreover, that multidrug resistance profile among MSM was negatively associated with recent travel. Across the surveillance project sites, first appearance of ciprofloxacin resistance in heterosexual men was positively correlated with such resistance for MSM. The increase in prevalence of ciprofloxacin resistance may have been facilitated by use of fluoroquinolones for treating gonorrhea and other conditions. The prominence of multidrug resistance suggests that using other classes of antimicrobial drugs for purposes other than treating gonorrhea helped increase the prevalence of ciprofloxacin-resistant strains that are also resistant to those drugs. |
| first_indexed | 2024-04-13T13:21:07Z |
| format | Article |
| id | doaj.art-d555f481feec4c4ca8f1c3fdd578f92c |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-04-13T13:21:07Z |
| publishDate | 2012-08-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-d555f481feec4c4ca8f1c3fdd578f92c2022-12-22T02:45:20ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592012-08-011881290129710.3201/eid1808.111202Factors Related to Increasing Prevalence of Resistance to Ciprofloxacin and Other Antimicrobial Drugs in Neisseria gonorrhoeae, United StatesEdward GoldsteinRobert D. KirkcaldyDavid ReshefStuart BermanHillard WeinstockPardis SabetiCarlos Del RioGeraldine HallEdward W. HookMarc LipsitchUsing data from the Gonococcal Isolate Surveillance Project, we studied changes in ciprofloxacin resistance in Neisseria gonorrhoeae isolates in the United States during 2002–2007. Compared with prevalence in heterosexual men, prevalence of ciprofloxacin-resistant N. gonorrhoeae infections showed a more pronounced increase in men who have sex with men (MSM), particularly through an increase in prevalence of strains also resistant to tetracycline and penicillin. Moreover, that multidrug resistance profile among MSM was negatively associated with recent travel. Across the surveillance project sites, first appearance of ciprofloxacin resistance in heterosexual men was positively correlated with such resistance for MSM. The increase in prevalence of ciprofloxacin resistance may have been facilitated by use of fluoroquinolones for treating gonorrhea and other conditions. The prominence of multidrug resistance suggests that using other classes of antimicrobial drugs for purposes other than treating gonorrhea helped increase the prevalence of ciprofloxacin-resistant strains that are also resistant to those drugs.https://wwwnc.cdc.gov/eid/article/18/8/11-1202_articleDrug-resistant N. gonorrhoeaemultidrug resistanceMSMbacteriagonorrheaNeisseria gonorrhoeae |
| spellingShingle | Edward Goldstein Robert D. Kirkcaldy David Reshef Stuart Berman Hillard Weinstock Pardis Sabeti Carlos Del Rio Geraldine Hall Edward W. Hook Marc Lipsitch Factors Related to Increasing Prevalence of Resistance to Ciprofloxacin and Other Antimicrobial Drugs in Neisseria gonorrhoeae, United States Emerging Infectious Diseases Drug-resistant N. gonorrhoeae multidrug resistance MSM bacteria gonorrhea Neisseria gonorrhoeae |
| title | Factors Related to Increasing Prevalence of Resistance to Ciprofloxacin and Other Antimicrobial Drugs in Neisseria gonorrhoeae, United States |
| title_full | Factors Related to Increasing Prevalence of Resistance to Ciprofloxacin and Other Antimicrobial Drugs in Neisseria gonorrhoeae, United States |
| title_fullStr | Factors Related to Increasing Prevalence of Resistance to Ciprofloxacin and Other Antimicrobial Drugs in Neisseria gonorrhoeae, United States |
| title_full_unstemmed | Factors Related to Increasing Prevalence of Resistance to Ciprofloxacin and Other Antimicrobial Drugs in Neisseria gonorrhoeae, United States |
| title_short | Factors Related to Increasing Prevalence of Resistance to Ciprofloxacin and Other Antimicrobial Drugs in Neisseria gonorrhoeae, United States |
| title_sort | factors related to increasing prevalence of resistance to ciprofloxacin and other antimicrobial drugs in neisseria gonorrhoeae united states |
| topic | Drug-resistant N. gonorrhoeae multidrug resistance MSM bacteria gonorrhea Neisseria gonorrhoeae |
| url | https://wwwnc.cdc.gov/eid/article/18/8/11-1202_article |
| work_keys_str_mv | AT edwardgoldstein factorsrelatedtoincreasingprevalenceofresistancetociprofloxacinandotherantimicrobialdrugsinneisseriagonorrhoeaeunitedstates AT robertdkirkcaldy factorsrelatedtoincreasingprevalenceofresistancetociprofloxacinandotherantimicrobialdrugsinneisseriagonorrhoeaeunitedstates AT davidreshef factorsrelatedtoincreasingprevalenceofresistancetociprofloxacinandotherantimicrobialdrugsinneisseriagonorrhoeaeunitedstates AT stuartberman factorsrelatedtoincreasingprevalenceofresistancetociprofloxacinandotherantimicrobialdrugsinneisseriagonorrhoeaeunitedstates AT hillardweinstock factorsrelatedtoincreasingprevalenceofresistancetociprofloxacinandotherantimicrobialdrugsinneisseriagonorrhoeaeunitedstates AT pardissabeti factorsrelatedtoincreasingprevalenceofresistancetociprofloxacinandotherantimicrobialdrugsinneisseriagonorrhoeaeunitedstates AT carlosdelrio factorsrelatedtoincreasingprevalenceofresistancetociprofloxacinandotherantimicrobialdrugsinneisseriagonorrhoeaeunitedstates AT geraldinehall factorsrelatedtoincreasingprevalenceofresistancetociprofloxacinandotherantimicrobialdrugsinneisseriagonorrhoeaeunitedstates AT edwardwhook factorsrelatedtoincreasingprevalenceofresistancetociprofloxacinandotherantimicrobialdrugsinneisseriagonorrhoeaeunitedstates AT marclipsitch factorsrelatedtoincreasingprevalenceofresistancetociprofloxacinandotherantimicrobialdrugsinneisseriagonorrhoeaeunitedstates |