Analysis of gait in Parkinson’s disease reflecting the effect of l-DOPA
BACKGROUND: Gait instability is one of the disabling clinical features of majority of patients suffering from Parkinson’s disease (PD). It is partially responsive to dopamine replacement therapy. Precise evaluation of distinct l-DOPA-sensitive and l-DOPA-resistant gait profiles might help in plannin...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2019-01-01
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| Series: | Annals of Movement Disorders |
| Subjects: | |
| Online Access: | http://www.aomd.in/article.asp?issn=2590-3446;year=2019;volume=2;issue=1;spage=21;epage=27;aulast=Mondal |
| _version_ | 1819115988992393216 |
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| author | Banashree Mondal Supriyo Choudhury Rebecca Banerjee Koustav Chatterjee Sayam Ghosal Sidharth S Anand Hrishikesh Kumar |
| author_facet | Banashree Mondal Supriyo Choudhury Rebecca Banerjee Koustav Chatterjee Sayam Ghosal Sidharth S Anand Hrishikesh Kumar |
| author_sort | Banashree Mondal |
| collection | DOAJ |
| description | BACKGROUND: Gait instability is one of the disabling clinical features of majority of patients suffering from Parkinson’s disease (PD). It is partially responsive to dopamine replacement therapy. Precise evaluation of distinct l-DOPA-sensitive and l-DOPA-resistant gait profiles might help in planning therapy of PD patients with gait disorder.METHOD: In this cross-sectional analytical study, we measured the gait parameters of 70 patients and 37 healthy participants using a 6.1-m long electronic walkway containing thousands of pressure sensors embedded in a carpet. The patients were evaluated in their OFF and ON phases of l-DOPA medication, and the data were compared with age- and gender-matched healthy controls.RESULTS: Except for the cadence, most gait parameters including velocity, stride length, and step length were deranged in PD patients. The mean velocity was significantly higher among healthy volunteers (99.19cm/s) compared to PD patients (73.90cm/s, P value 0.0001). However, the mean cadence was comparable between healthy and patient groups (103.29 vs. 103.39, P value 0.966). Certain temporal parameters (cadence, cycle time, and swing time) were nonresponsive to the dopaminergic therapy.CONCLUSION: On the basis of the findings, we propose that l-DOPA treatment improves most of the spatiotemporal gait parameters but cannot completely eliminate the risk of fall. |
| first_indexed | 2024-12-22T05:09:57Z |
| format | Article |
| id | doaj.art-d557d86420774cb1845e7a6449608771 |
| institution | Directory Open Access Journal |
| issn | 2590-3446 2590-3454 |
| language | English |
| last_indexed | 2024-12-22T05:09:57Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Movement Disorders |
| spelling | doaj.art-d557d86420774cb1845e7a64496087712022-12-21T18:38:00ZengWolters Kluwer Medknow PublicationsAnnals of Movement Disorders2590-34462590-34542019-01-0121212710.4103/AOMD.AOMD_19_18Analysis of gait in Parkinson’s disease reflecting the effect of l-DOPABanashree MondalSupriyo ChoudhuryRebecca BanerjeeKoustav ChatterjeeSayam GhosalSidharth S AnandHrishikesh KumarBACKGROUND: Gait instability is one of the disabling clinical features of majority of patients suffering from Parkinson’s disease (PD). It is partially responsive to dopamine replacement therapy. Precise evaluation of distinct l-DOPA-sensitive and l-DOPA-resistant gait profiles might help in planning therapy of PD patients with gait disorder.METHOD: In this cross-sectional analytical study, we measured the gait parameters of 70 patients and 37 healthy participants using a 6.1-m long electronic walkway containing thousands of pressure sensors embedded in a carpet. The patients were evaluated in their OFF and ON phases of l-DOPA medication, and the data were compared with age- and gender-matched healthy controls.RESULTS: Except for the cadence, most gait parameters including velocity, stride length, and step length were deranged in PD patients. The mean velocity was significantly higher among healthy volunteers (99.19cm/s) compared to PD patients (73.90cm/s, P value 0.0001). However, the mean cadence was comparable between healthy and patient groups (103.29 vs. 103.39, P value 0.966). Certain temporal parameters (cadence, cycle time, and swing time) were nonresponsive to the dopaminergic therapy.CONCLUSION: On the basis of the findings, we propose that l-DOPA treatment improves most of the spatiotemporal gait parameters but cannot completely eliminate the risk of fall.http://www.aomd.in/article.asp?issn=2590-3446;year=2019;volume=2;issue=1;spage=21;epage=27;aulast=Mondaldopa responsivenessgaitgaitrite®parkinson’s disease |
| spellingShingle | Banashree Mondal Supriyo Choudhury Rebecca Banerjee Koustav Chatterjee Sayam Ghosal Sidharth S Anand Hrishikesh Kumar Analysis of gait in Parkinson’s disease reflecting the effect of l-DOPA Annals of Movement Disorders dopa responsiveness gait gaitrite® parkinson’s disease |
| title | Analysis of gait in Parkinson’s disease reflecting the effect of l-DOPA |
| title_full | Analysis of gait in Parkinson’s disease reflecting the effect of l-DOPA |
| title_fullStr | Analysis of gait in Parkinson’s disease reflecting the effect of l-DOPA |
| title_full_unstemmed | Analysis of gait in Parkinson’s disease reflecting the effect of l-DOPA |
| title_short | Analysis of gait in Parkinson’s disease reflecting the effect of l-DOPA |
| title_sort | analysis of gait in parkinson s disease reflecting the effect of l dopa |
| topic | dopa responsiveness gait gaitrite® parkinson’s disease |
| url | http://www.aomd.in/article.asp?issn=2590-3446;year=2019;volume=2;issue=1;spage=21;epage=27;aulast=Mondal |
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