Both IRBIT and long-IRBIT bind to and coordinately regulate Cl−/HCO3 − exchanger AE2 activity through modulating the lysosomal degradation of AE2

Both IRBIT and long-IRBIT bind to and coordinately regulate Cl−/HCO3 − exchanger AE2 activity through modulating the lysosomal degradation of AE2

Abstract Anion exchanger 2 (AE2) plays crucial roles in regulating cell volume homeostasis and cell migration. We found that both IRBIT and Long-IRBIT (L-IRBIT) interact with anion exchanger 2 (AE2). The interaction occurred between the conserved AHCY-homologous domain of IRBIT/L-IRBIT and the N-ter...

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Main Authors: Ryo Itoh, Naoya Hatano, Momoko Murakami, Kosuke Mitsumori, Satoko Kawasaki, Tomoka Wakagi, Yoshino Kanzaki, Hiroyuki Kojima, Katsuhiro Kawaai, Katsuhiko Mikoshiba, Koichi Hamada, Akihiro Mizutani
Format: Article
Language:English
Published: Nature Portfolio 2021-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-85499-6

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