Clostridium perfringens Epsilon Toxin Compromises the Blood-Brain Barrier in a Humanized Zebrafish Model

Clostridium perfringens Epsilon Toxin Compromises the Blood-Brain Barrier in a Humanized Zebrafish Model

Summary: Clostridium perfringens epsilon toxin (ETX) is hypothesized to mediate blood-brain barrier (BBB) permeability by binding to the myelin and lymphocyte protein (MAL) on the luminal surface of endothelial cells (ECs). However, the kinetics of this interaction and a general understanding of ETX...

Full description

Bibliographic Details
Main Authors:	Drew Adler, Jennifer R. Linden, Samantha V. Shetty, Yinghua Ma, Monika Bokori-Brown, Richard W. Titball, Timothy Vartanian
Format:	Article
Language:	English
Published:	Elsevier 2019-05-01
Series:	iScience
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004219301130

Similar Items

The pore structure of Clostridium perfringens epsilon toxin
by: Christos G. Savva, et al.
Published: (2019-06-01)

<i>Clostridium perfringens</i> Epsilon Toxin Binds to and Kills Primary Human Lymphocytes
by: Samantha V. Shetty, et al.
Published: (2023-06-01)

Clostridium perfringens epsilon toxin induces blood brain barrier permeability via caveolae-dependent transcytosis and requires expression of MAL.
by: Jennifer R Linden, et al.
Published: (2019-11-01)

A Novel Panel of Rabbit Monoclonal Antibodies and Their Diverse Applications Including Inhibition of <i>Clostridium perfringens</i> Epsilon Toxin Oligomerization
by: Jennifer R. Linden, et al.
Published: (2018-10-01)

Clostridium perfringens epsilon toxin: Toxic effects and mechanisms of action
by: Wenwen Xin, et al.
Published: (2019-09-01)

<named-content content-type="genus-species">Clostridium perfringens</named-content> Epsilon Toxin Causes Selective Death of Mature Oligodendrocytes and Central Nervous System Demyelination
by: Jennifer R. Linden, et al.
Published: (2015-07-01)

Clostridium perfringens Epsilon Toxin: A Malevolent Molecule for Animals and Man?
by: Michel R. Popoff, et al.
Published: (2013-11-01)

Evidence for a prepore stage in the action of Clostridium perfringens epsilon toxin.
by: Susan L Robertson, et al.
Published: (2011-01-01)

Lung endothelial cells are sensitive to epsilon toxin from Clostridium perfringens
by: Jonatan Dorca-Arévalo, et al.
Published: (2020-02-01)

Interaction of <i>Clostridium perfringens</i> Epsilon Toxin with the Plasma Membrane: The Role of Amino Acids Y42, Y43 and H162
by: Skye Marshall, et al.
Published: (2022-11-01)

Oligomerization of Clostridium perfringens epsilon toxin is dependent upon caveolins 1 and 2.
by: Christine M Fennessey, et al.
Published: (2012-01-01)

Clostridium perfringens epsilon toxin increases the small intestinal permeability in mice and rats.
by: Jorge Goldstein, et al.
Published: (2009-09-01)

Epsilon toxin–producing Clostridium perfringens colonize the multiple sclerosis gut microbiome overcoming CNS immune privilege
by: Yinghua Ma, et al.
Published: (2023-05-01)

Correction: Clostridium perfringens Epsilon Toxin Increases the Small Intestinal Permeability in Mice and Rats
Published: (2013-01-01)

The Myelin and Lymphocyte Protein MAL Is Required for Binding and Activity of Clostridium perfringens ε-Toxin.
by: Kareem Rashid Rumah, et al.
Published: (2015-05-01)

Recombinant Alpha, Beta, and Epsilon Toxins of Clostridium perfringens: Production Strategies and Applications as Veterinary Vaccines
by: Marcos Roberto A. Ferreira, et al.
Published: (2016-11-01)

Clostridium perfringens epsilon toxin targets granule cells in the mouse cerebellum and stimulates glutamate release.
by: Etienne Lonchamp, et al.
Published: (2010-09-01)

Clostridium Perfringens Epsilon Toxin Binds to Membrane Lipids and Its Cytotoxic Action Depends on Sulfatide.
by: Carles Gil, et al.
Published: (2015-01-01)

Hemolysis in human erythrocytes by Clostridium perfringens epsilon toxin requires activation of P2 receptors
by: Jie Gao, et al.
Published: (2018-12-01)

Produção e caracterização de anticorpos monoclonais contra toxina épsilon de Clostridium perfringens Tipo D Production and characterization of monoclonal antibodies against Clostridium perfringens Type D epsilon toxin
by: Theonys Diógenes Freitas, et al.
Published: (2009-02-01)

Pathology and Pathogenesis of Brain Lesions Produced by <i>Clostridium perfringens</i> Type D Epsilon Toxin
by: John W. Finnie, et al.
Published: (2022-08-01)

Immunization with recombinant fusion of LTB and linear epitope (40–62) of epsilon toxin elicits protective immune response against the epsilon toxin of Clostridium perfringens type D
by: Himani Kaushik, et al.
Published: (2019-07-01)

F199E substitution reduced toxicity of Clostridium perfringens epsilon toxin by depriving the receptor binding capability
by: Jingjing Kang, et al.
Published: (2017-07-01)

Correlation between in vitro cytotoxicity and in vivo lethal activity in mice of epsilon toxin mutants from Clostridium perfringens.
by: Jonatan Dorca-Arévalo, et al.
Published: (2014-01-01)

Fusion of Clostridium perfringens type D and B epsilon and beta toxin genes and it’s cloning in E. coli
by: Goudarzi, H.,, et al.
Published: (2011-06-01)

Molecular Detection of Clostridium perfringens Type D Alpha and Epsilon Toxin Genes from Various Tissues in Lambs
by: Azam Ali Nasir1,3, Muhammad Younus2,*, Muti-ur-Rehman3, Muhammad Latif3, Asif Rashid1, Rashid Ahmad1 and Muhammad Abbas1
Published: (2013-11-01)

Stability and toxicity of Clostridium perfringens type D epsilon prototoxin treated by iodine Estabilidade e toxicidade da protoxina epsilon de Clostridium perfringens tipo D
by: P.H. Rocha, et al.
Published: (2008-08-01)

<i>Clostridium perfringens</i> Type D Epsilon Toxin Causes Blood–Retinal Barrier Microvascular Damage and Diffuse Retinal Vasogenic Oedema
by: John W. Finnie
Published: (2023-12-01)

Identification of a Key Residue for Oligomerisation and Pore-Formation of Clostridium perfringens NetB
by: Sérgio P. Fernandes da Costa, et al.
Published: (2014-03-01)

Regulation of Toxin Production in Clostridium perfringens
by: Kaori Ohtani, et al.
Published: (2016-07-01)

Production and purification of epsilon prototoxin produced by Clostridium perfringens type D
by: P.M. Parreiras, et al.
Published: (2002-06-01)

Antibody responses in buffalos immunized with Clostridium perfringens beta and epsilon toxoids
by: S. M Rahman, et al.
Published: (2001-09-01)

Purification, crystallization and preliminary X-ray diffraction studies of alpha-toxin of Clostridium perfringens.
by: Basak, A, et al.
Published: (1994)

<i>Clostridium perfringens</i> Epsilon-Toxin Impairs the Barrier Function in MDCK Cell Monolayers in a Ca<sup>2+</sup>-Dependent Manner
by: Masahiro Nagahama, et al.
Published: (2020-04-01)

Epsilon Toxin from <i>Clostridium perfringens</i> Causes Inhibition of Potassium inward Rectifier (Kir) Channels in Oligodendrocytes
by: Jean Louis Bossu, et al.
Published: (2020-01-01)

In vitro potency test for evaluation of Clostridium perfringens type D epsilon toxoid
by: Felipe Masiero Salvarini, et al.

Perfringolysin O: The Underrated Clostridium perfringens Toxin?
by: Stefanie Verherstraeten, et al.
Published: (2015-05-01)

Effect of Clostridium perfringens β-Toxin on Platelets
by: Anne Thiel, et al.
Published: (2017-10-01)

Recent Insights into Clostridium perfringens Beta-Toxin
by: Masahiro Nagahama, et al.
Published: (2015-02-01)

New Mutants of Epsilon Toxin from <i>Clostridium perfringens</i> with an Altered Receptor-Binding Site and Cell-Type Specificity
by: Jonatan Dorca-Arévalo, et al.
Published: (2022-04-01)