Neuroendocrine Differentiation of Prostate Cancer Is Not Systematically Associated with Increased 18F-FDG Uptake
Neuroendocrine differentiation (NED) of prostate cancer represents an acknowledged predictor of resistant and more aggressive disease. NED can be functionally exploited in vivo using PET/CT imaging with somatostatin analogs radiolabeled with 68Ga. Many previous reports have shown that 18F-FDG PET/CT...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-03-01
|
| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/11/3/468 |
| _version_ | 1797412537514328064 |
|---|---|
| author | Matteo Bauckneht Silvia Morbelli Alberto Miceli Sara Elena Rebuzzi Giuseppe Fornarini |
| author_facet | Matteo Bauckneht Silvia Morbelli Alberto Miceli Sara Elena Rebuzzi Giuseppe Fornarini |
| author_sort | Matteo Bauckneht |
| collection | DOAJ |
| description | Neuroendocrine differentiation (NED) of prostate cancer represents an acknowledged predictor of resistant and more aggressive disease. NED can be functionally exploited in vivo using PET/CT imaging with somatostatin analogs radiolabeled with 68Ga. Many previous reports have shown that 18F-FDG PET/CT should also be used in cases such as guiding management, as NED is systematically associated with increased glycolysis. We hereby discuss the case of a metastatic prostate cancer patient in which 68Ga-Dotatoc PET/CT revealed the occurrence of NED with low FDG-avidity. |
| first_indexed | 2024-03-09T05:04:26Z |
| format | Article |
| id | doaj.art-d55a928950384b84a0a60da59feb017a |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T05:04:26Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-d55a928950384b84a0a60da59feb017a2023-12-03T12:57:07ZengMDPI AGDiagnostics2075-44182021-03-0111346810.3390/diagnostics11030468Neuroendocrine Differentiation of Prostate Cancer Is Not Systematically Associated with Increased 18F-FDG UptakeMatteo Bauckneht0Silvia Morbelli1Alberto Miceli2Sara Elena Rebuzzi3Giuseppe Fornarini4Nuclear Medicine, IRCCS Ospedale Policlinico San Martino, 16132 Genova, ItalyNuclear Medicine, IRCCS Ospedale Policlinico San Martino, 16132 Genova, ItalyDepartment of Health Sciences (DISSAL), University of Genova, 16132 Genova, ItalyMedical Oncology Unit 1, IRCCS Ospedale Policlinico San Martino, 16132 Genova, ItalyMedical Oncology Unit 1, IRCCS Ospedale Policlinico San Martino, 16132 Genova, ItalyNeuroendocrine differentiation (NED) of prostate cancer represents an acknowledged predictor of resistant and more aggressive disease. NED can be functionally exploited in vivo using PET/CT imaging with somatostatin analogs radiolabeled with 68Ga. Many previous reports have shown that 18F-FDG PET/CT should also be used in cases such as guiding management, as NED is systematically associated with increased glycolysis. We hereby discuss the case of a metastatic prostate cancer patient in which 68Ga-Dotatoc PET/CT revealed the occurrence of NED with low FDG-avidity.https://www.mdpi.com/2075-4418/11/3/468metastatic castration-resistant prostate cancerneuroendocrine differentiationpositron emission tomography18F-Fluorodeoxyglucose68Ga-Dotatoc |
| spellingShingle | Matteo Bauckneht Silvia Morbelli Alberto Miceli Sara Elena Rebuzzi Giuseppe Fornarini Neuroendocrine Differentiation of Prostate Cancer Is Not Systematically Associated with Increased 18F-FDG Uptake Diagnostics metastatic castration-resistant prostate cancer neuroendocrine differentiation positron emission tomography 18F-Fluorodeoxyglucose 68Ga-Dotatoc |
| title | Neuroendocrine Differentiation of Prostate Cancer Is Not Systematically Associated with Increased 18F-FDG Uptake |
| title_full | Neuroendocrine Differentiation of Prostate Cancer Is Not Systematically Associated with Increased 18F-FDG Uptake |
| title_fullStr | Neuroendocrine Differentiation of Prostate Cancer Is Not Systematically Associated with Increased 18F-FDG Uptake |
| title_full_unstemmed | Neuroendocrine Differentiation of Prostate Cancer Is Not Systematically Associated with Increased 18F-FDG Uptake |
| title_short | Neuroendocrine Differentiation of Prostate Cancer Is Not Systematically Associated with Increased 18F-FDG Uptake |
| title_sort | neuroendocrine differentiation of prostate cancer is not systematically associated with increased 18f fdg uptake |
| topic | metastatic castration-resistant prostate cancer neuroendocrine differentiation positron emission tomography 18F-Fluorodeoxyglucose 68Ga-Dotatoc |
| url | https://www.mdpi.com/2075-4418/11/3/468 |
| work_keys_str_mv | AT matteobauckneht neuroendocrinedifferentiationofprostatecancerisnotsystematicallyassociatedwithincreased18ffdguptake AT silviamorbelli neuroendocrinedifferentiationofprostatecancerisnotsystematicallyassociatedwithincreased18ffdguptake AT albertomiceli neuroendocrinedifferentiationofprostatecancerisnotsystematicallyassociatedwithincreased18ffdguptake AT saraelenarebuzzi neuroendocrinedifferentiationofprostatecancerisnotsystematicallyassociatedwithincreased18ffdguptake AT giuseppefornarini neuroendocrinedifferentiationofprostatecancerisnotsystematicallyassociatedwithincreased18ffdguptake |