Coupling DNA Replication and Spindle Function in <i>Saccharomyces cerevisiae</i>
In the yeast <i>Saccharomyces cerevisiae</i> DNA replication and spindle assembly can overlap. Therefore, signaling mechanisms modulate spindle dynamics in order to ensure correct timing of chromosome segregation relative to genome duplication, especially when replication is incomplete o...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/12/3359 |
| _version_ | 1797505989815042048 |
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| author | Dimitris Liakopoulos |
| author_facet | Dimitris Liakopoulos |
| author_sort | Dimitris Liakopoulos |
| collection | DOAJ |
| description | In the yeast <i>Saccharomyces cerevisiae</i> DNA replication and spindle assembly can overlap. Therefore, signaling mechanisms modulate spindle dynamics in order to ensure correct timing of chromosome segregation relative to genome duplication, especially when replication is incomplete or the DNA becomes damaged. This review focuses on the molecular mechanisms that coordinate DNA replication and spindle dynamics, as well as on the role of spindle-dependent forces in DNA repair. Understanding the coupling between genome duplication and spindle function in yeast cells can provide important insights into similar processes operating in other eukaryotic organisms, including humans. |
| first_indexed | 2024-03-10T04:26:13Z |
| format | Article |
| id | doaj.art-d55aaf69d65d458c93b09729eafe1079 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T04:26:13Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-d55aaf69d65d458c93b09729eafe10792023-11-23T07:36:41ZengMDPI AGCells2073-44092021-11-011012335910.3390/cells10123359Coupling DNA Replication and Spindle Function in <i>Saccharomyces cerevisiae</i>Dimitris Liakopoulos0CRBM, Université de Montpellier, CNRS, 1919 Route de Mende, 34293 Montpellier, FranceIn the yeast <i>Saccharomyces cerevisiae</i> DNA replication and spindle assembly can overlap. Therefore, signaling mechanisms modulate spindle dynamics in order to ensure correct timing of chromosome segregation relative to genome duplication, especially when replication is incomplete or the DNA becomes damaged. This review focuses on the molecular mechanisms that coordinate DNA replication and spindle dynamics, as well as on the role of spindle-dependent forces in DNA repair. Understanding the coupling between genome duplication and spindle function in yeast cells can provide important insights into similar processes operating in other eukaryotic organisms, including humans.https://www.mdpi.com/2073-4409/10/12/3359spindlereplicationS-phase checkpointcell cycleyeast |
| spellingShingle | Dimitris Liakopoulos Coupling DNA Replication and Spindle Function in <i>Saccharomyces cerevisiae</i> Cells spindle replication S-phase checkpoint cell cycle yeast |
| title | Coupling DNA Replication and Spindle Function in <i>Saccharomyces cerevisiae</i> |
| title_full | Coupling DNA Replication and Spindle Function in <i>Saccharomyces cerevisiae</i> |
| title_fullStr | Coupling DNA Replication and Spindle Function in <i>Saccharomyces cerevisiae</i> |
| title_full_unstemmed | Coupling DNA Replication and Spindle Function in <i>Saccharomyces cerevisiae</i> |
| title_short | Coupling DNA Replication and Spindle Function in <i>Saccharomyces cerevisiae</i> |
| title_sort | coupling dna replication and spindle function in i saccharomyces cerevisiae i |
| topic | spindle replication S-phase checkpoint cell cycle yeast |
| url | https://www.mdpi.com/2073-4409/10/12/3359 |
| work_keys_str_mv | AT dimitrisliakopoulos couplingdnareplicationandspindlefunctioninisaccharomycescerevisiaei |