Effect of cocoa (Theobroma cacao L.) on platelet function testing profiles in patients with coronary artery disease: ECLAIR pilot study
Introduction This prospective pharmacodynamic nutraceutical study assessed the effect of a 1-week trial of 30 g/day of 65% cocoa (dark chocolate) (Theobroma cacao L.) consumption intervention on platelet reactivity.Methods Patients with stable coronary artery disease (CAD) (n=20) who were on mainten...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2022-08-01
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| Series: | Open Heart |
| Online Access: | https://openheart.bmj.com/content/9/2/e002066.full |
| _version_ | 1827902591528337408 |
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| author | Naveen Anand Seecheran Rajeev Seecheran Valmiki Seecheran Sherry Sandy Stanley Giddings Antonio Tello-Montoliu David Schneider Anil Ramlackhansingh Darin Sukha Kathryn Grimaldos Gabriella Grimaldos Srivane Richard Aleena Ishmael Ceylon Gomes Lirmala Kampradi Lakshmipathi Peram Darren Dookeeram Sadi Raza Pathmanathan Umaharan |
| author_facet | Naveen Anand Seecheran Rajeev Seecheran Valmiki Seecheran Sherry Sandy Stanley Giddings Antonio Tello-Montoliu David Schneider Anil Ramlackhansingh Darin Sukha Kathryn Grimaldos Gabriella Grimaldos Srivane Richard Aleena Ishmael Ceylon Gomes Lirmala Kampradi Lakshmipathi Peram Darren Dookeeram Sadi Raza Pathmanathan Umaharan |
| author_sort | Naveen Anand Seecheran |
| collection | DOAJ |
| description | Introduction This prospective pharmacodynamic nutraceutical study assessed the effect of a 1-week trial of 30 g/day of 65% cocoa (dark chocolate) (Theobroma cacao L.) consumption intervention on platelet reactivity.Methods Patients with stable coronary artery disease (CAD) (n=20) who were on maintenance dual antiplatelet therapy of aspirin (ASA) 81 mg/day and clopidogrel 75 mg/day were recruited. Platelet function was evaluated with the VerifyNow P2Y12 reaction unit (PRU) and aspirin reaction unit (ARU) assays (Werfen, Bedford, Massachusetts, USA) and assessed prior to initiation of and after a 1-week trial of 30 g/day of 65% cocoa consumption intervention. Results were compared with a paired t-test.Results Cocoa augmented the inhibitory effect of clopidogrel, demonstrated by a reduction of 11.9% (95% CI 5.7% to 18.0%, p value 0.001), significantly decreasing the PRU by 26.85 (95% CI 12.22 to 41.48, p value 0.001). The inhibitory effect of ASA was not impacted by cocoa, reflected by a non-significant reduction in ARU of 17.65 (95% CI 21.00 to 56.3, p value 0.351). No patients experienced any serious adverse events.Conclusions Cocoa augmented the inhibitory effect of clopidogrel but not ASA. This nutraceutical study could be potentially informative and applicable for patients with stable CAD. Further long-term studies are required to confirm these exploratory findings.Trial registration number NCT04554901. |
| first_indexed | 2024-03-13T00:01:23Z |
| format | Article |
| id | doaj.art-d55d7cd28b424dfc933834616e5281a6 |
| institution | Directory Open Access Journal |
| issn | 2053-3624 |
| language | English |
| last_indexed | 2024-03-13T00:01:23Z |
| publishDate | 2022-08-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | Open Heart |
| spelling | doaj.art-d55d7cd28b424dfc933834616e5281a62023-07-13T11:30:06ZengBMJ Publishing GroupOpen Heart2053-36242022-08-019210.1136/openhrt-2022-002066Effect of cocoa (Theobroma cacao L.) on platelet function testing profiles in patients with coronary artery disease: ECLAIR pilot studyNaveen Anand Seecheran0Rajeev Seecheran1Valmiki Seecheran2Sherry Sandy3Stanley Giddings4Antonio Tello-Montoliu5David Schneider6Anil Ramlackhansingh7Darin Sukha8Kathryn Grimaldos9Gabriella Grimaldos10Srivane Richard11Aleena Ishmael12Ceylon Gomes13Lirmala Kampradi14Lakshmipathi Peram15Darren Dookeeram16Sadi Raza17Pathmanathan Umaharan18Clinical Medical Sciences, The University of the West Indies, Saint Augustine, Trinidad and TobagoDepartment of Medicine, University of Kansas Medical Center, Wichita, Kansas, USADepartment of Medicine, North Central Regional Health Authority, Champ Fleurs, Trinidad and TobagoClinical Medical Sciences, The University of the West Indies, Saint Augustine, Trinidad and TobagoClinical Medical Sciences, The University of the West Indies, Saint Augustine, Trinidad and TobagoCardiology Division, Universidad de Murcia, Murcia, SpainCardiology Division, University of Vermont Medical Center, Burlington, Vermont, USAClinical Medical Sciences, The University of the West Indies, Saint Augustine, Trinidad and TobagoCocoa Research Centre, The University of the West Indies, Saint Augustine, Trinidad and TobagoDepartment of Medicine, North Central Regional Health Authority, Champ Fleurs, Trinidad and TobagoDepartment of Medicine, North Central Regional Health Authority, Champ Fleurs, Trinidad and TobagoDepartment of Medicine, North Central Regional Health Authority, Champ Fleurs, Trinidad and TobagoDepartment of Medicine, North Central Regional Health Authority, Champ Fleurs, Trinidad and TobagoDepartment of Medicine, North Central Regional Health Authority, Champ Fleurs, Trinidad and TobagoDepartment of Medicine, North Central Regional Health Authority, Champ Fleurs, Trinidad and TobagoDepartment of Medicine, North Central Regional Health Authority, Champ Fleurs, Trinidad and TobagoDepartment of Medicine, North Central Regional Health Authority, Champ Fleurs, Trinidad and TobagoCardiology Division, HeartPlace, Dallas, Texas, USACocoa Research Centre, The University of the West Indies, Saint Augustine, Trinidad and TobagoIntroduction This prospective pharmacodynamic nutraceutical study assessed the effect of a 1-week trial of 30 g/day of 65% cocoa (dark chocolate) (Theobroma cacao L.) consumption intervention on platelet reactivity.Methods Patients with stable coronary artery disease (CAD) (n=20) who were on maintenance dual antiplatelet therapy of aspirin (ASA) 81 mg/day and clopidogrel 75 mg/day were recruited. Platelet function was evaluated with the VerifyNow P2Y12 reaction unit (PRU) and aspirin reaction unit (ARU) assays (Werfen, Bedford, Massachusetts, USA) and assessed prior to initiation of and after a 1-week trial of 30 g/day of 65% cocoa consumption intervention. Results were compared with a paired t-test.Results Cocoa augmented the inhibitory effect of clopidogrel, demonstrated by a reduction of 11.9% (95% CI 5.7% to 18.0%, p value 0.001), significantly decreasing the PRU by 26.85 (95% CI 12.22 to 41.48, p value 0.001). The inhibitory effect of ASA was not impacted by cocoa, reflected by a non-significant reduction in ARU of 17.65 (95% CI 21.00 to 56.3, p value 0.351). No patients experienced any serious adverse events.Conclusions Cocoa augmented the inhibitory effect of clopidogrel but not ASA. This nutraceutical study could be potentially informative and applicable for patients with stable CAD. Further long-term studies are required to confirm these exploratory findings.Trial registration number NCT04554901.https://openheart.bmj.com/content/9/2/e002066.full |
| spellingShingle | Naveen Anand Seecheran Rajeev Seecheran Valmiki Seecheran Sherry Sandy Stanley Giddings Antonio Tello-Montoliu David Schneider Anil Ramlackhansingh Darin Sukha Kathryn Grimaldos Gabriella Grimaldos Srivane Richard Aleena Ishmael Ceylon Gomes Lirmala Kampradi Lakshmipathi Peram Darren Dookeeram Sadi Raza Pathmanathan Umaharan Effect of cocoa (Theobroma cacao L.) on platelet function testing profiles in patients with coronary artery disease: ECLAIR pilot study Open Heart |
| title | Effect of cocoa (Theobroma cacao L.) on platelet function testing profiles in patients with coronary artery disease: ECLAIR pilot study |
| title_full | Effect of cocoa (Theobroma cacao L.) on platelet function testing profiles in patients with coronary artery disease: ECLAIR pilot study |
| title_fullStr | Effect of cocoa (Theobroma cacao L.) on platelet function testing profiles in patients with coronary artery disease: ECLAIR pilot study |
| title_full_unstemmed | Effect of cocoa (Theobroma cacao L.) on platelet function testing profiles in patients with coronary artery disease: ECLAIR pilot study |
| title_short | Effect of cocoa (Theobroma cacao L.) on platelet function testing profiles in patients with coronary artery disease: ECLAIR pilot study |
| title_sort | effect of cocoa theobroma cacao l on platelet function testing profiles in patients with coronary artery disease eclair pilot study |
| url | https://openheart.bmj.com/content/9/2/e002066.full |
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