Serious Underlying Medical Conditions and COVID-19 Vaccine Hesitancy: A Large Cross-Sectional Analysis from Australia
As COVID-19 vaccinations became available and were proven effective in preventing serious infection, uptake amongst individuals varied, including in medically vulnerable populations. This cross-sectional multi-site study examined vaccine uptake, hesitancy, and explanatory factors amongst people with...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/10/6/851 |
| _version_ | 1827656153996197888 |
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| author | Daphne Day Lisa Grech Mike Nguyen Nathan Bain Alastair Kwok Sam Harris Hieu Chau Bryan Chan Richard Blennerhassett Louise Nott Nada Hamad Annette Tognela David Hoffman Amelia McCartney Kate Webber Jennifer Wong Craig Underhill Brett Sillars Antony Winkel Mark Savage Bao Sheng Loe Daniel Freeman Eva Segelov on behalf of the CANVACCS, DIABVACCS and MSVACCS Investigators |
| author_facet | Daphne Day Lisa Grech Mike Nguyen Nathan Bain Alastair Kwok Sam Harris Hieu Chau Bryan Chan Richard Blennerhassett Louise Nott Nada Hamad Annette Tognela David Hoffman Amelia McCartney Kate Webber Jennifer Wong Craig Underhill Brett Sillars Antony Winkel Mark Savage Bao Sheng Loe Daniel Freeman Eva Segelov on behalf of the CANVACCS, DIABVACCS and MSVACCS Investigators |
| author_sort | Daphne Day |
| collection | DOAJ |
| description | As COVID-19 vaccinations became available and were proven effective in preventing serious infection, uptake amongst individuals varied, including in medically vulnerable populations. This cross-sectional multi-site study examined vaccine uptake, hesitancy, and explanatory factors amongst people with serious and/or chronic health conditions, including the impact of underlying disease on attitudes to vaccination. A 42-item survey was distributed to people with cancer, diabetes, or multiple sclerosis across ten Australian health services from 30 June to 5 October 2021. The survey evaluated sociodemographic and disease-related characteristics and incorporated three validated scales measuring vaccine hesitancy and vaccine-related beliefs generally and specific to their disease: the Oxford COVID-19 Vaccine Hesitancy Scale, the Oxford COVID-19 Vaccine Confidence and Complacency Scale and the Disease Influenced Vaccine Acceptance Scale-Six. Among 4683 participants (2548 [54.4%] female, 2108 [45.0%] male, 27 [0.6%] other; mean [SD] age, 60.6 [13.3] years; 3560 [76.0%] cancer, 842 [18.0%] diabetes, and 281 [6.0%] multiple sclerosis), 3813 (81.5%) self-reported having at least one COVID-19 vaccine. Unvaccinated status was associated with younger age, female sex, lower education and income, English as a second language, and residence in regional areas. Unvaccinated participants were more likely to report greater vaccine hesitancy and more negative perceptions toward vaccines. Disease-related vaccine concerns were associated with unvaccinated status and hesitancy, including greater complacency about COVID-19 infection, and concerns relating to vaccine efficacy and impact on their disease and/or treatment. This highlights the need to develop targeted strategies and education about COVID-19 vaccination to support medically vulnerable populations and health professionals. |
| first_indexed | 2024-03-09T22:17:38Z |
| format | Article |
| id | doaj.art-d55efc600f1647f7837aaf47093bbd8f |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T22:17:38Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-d55efc600f1647f7837aaf47093bbd8f2023-11-23T19:20:15ZengMDPI AGVaccines2076-393X2022-05-0110685110.3390/vaccines10060851Serious Underlying Medical Conditions and COVID-19 Vaccine Hesitancy: A Large Cross-Sectional Analysis from AustraliaDaphne Day0Lisa Grech1Mike Nguyen2Nathan Bain3Alastair Kwok4Sam Harris5Hieu Chau6Bryan Chan7Richard Blennerhassett8Louise Nott9Nada Hamad10Annette Tognela11David Hoffman12Amelia McCartney13Kate Webber14Jennifer Wong15Craig Underhill16Brett Sillars17Antony Winkel18Mark Savage19Bao Sheng Loe20Daniel Freeman21Eva Segelov22on behalf of the CANVACCS, DIABVACCS and MSVACCS InvestigatorsDepartment of Oncology, Monash Health, Clayton, VIC 3168, AustraliaDepartment of Medicine, School of Clinical Sciences, Monash University, Clayton, VIC 3168, AustraliaDepartment of Oncology, Monash Health, Clayton, VIC 3168, AustraliaDepartment of Oncology, Monash Health, Clayton, VIC 3168, AustraliaDepartment of Oncology, Monash Health, Clayton, VIC 3168, AustraliaDepartment of Medical Oncology, Bendigo Health, Bendigo, VIC 3550, AustraliaDepartment of Oncology, Latrobe Regional Hospital, Traralgon, VIC 3844, AustraliaDepartment of Oncology, Sunshine Coast Hospital and Health Service, Birtinya, QLD 4575, AustraliaCentral Coast Haematology, North Gosford, NSW 2250, AustraliaIcon Cancer Centre Hobart, Hobart, TAS 7000, AustraliaDepartment of Haematology, St Vincent’s Hospital Sydney, Darlinghurst, NSW 2010, AustraliaMacarthur Cancer Therapy Centre, Campbelltown Hospital, Campbelltown, NSW 2560, AustraliaDr David Hoffman, Fairfield, NSW 2165, AustraliaDepartment of Oncology, Monash Health, Clayton, VIC 3168, AustraliaDepartment of Oncology, Monash Health, Clayton, VIC 3168, AustraliaDepartment of Medicine, School of Clinical Sciences, Monash University, Clayton, VIC 3168, AustraliaBorder Medical Oncology, Albury, NSW 2640, AustraliaDepartment of Endocrinology, Sunshine Coast Hospital and Health Service, Birtinya, QLD 4575, AustraliaSchool of Medicine, Griffith University, Birtinya, QLD 4575, AustraliaDepartment of Endocrinology, Bendigo Health, Bendigo, VIC 3550, AustraliaThe Psychometrics Centre, University of Cambridge, Cambridge CB2 1AG, UKDepartment of Psychiatry, University of Oxford, Oxford OX3 7JX, UKDepartment of Oncology, Monash Health, Clayton, VIC 3168, AustraliaAs COVID-19 vaccinations became available and were proven effective in preventing serious infection, uptake amongst individuals varied, including in medically vulnerable populations. This cross-sectional multi-site study examined vaccine uptake, hesitancy, and explanatory factors amongst people with serious and/or chronic health conditions, including the impact of underlying disease on attitudes to vaccination. A 42-item survey was distributed to people with cancer, diabetes, or multiple sclerosis across ten Australian health services from 30 June to 5 October 2021. The survey evaluated sociodemographic and disease-related characteristics and incorporated three validated scales measuring vaccine hesitancy and vaccine-related beliefs generally and specific to their disease: the Oxford COVID-19 Vaccine Hesitancy Scale, the Oxford COVID-19 Vaccine Confidence and Complacency Scale and the Disease Influenced Vaccine Acceptance Scale-Six. Among 4683 participants (2548 [54.4%] female, 2108 [45.0%] male, 27 [0.6%] other; mean [SD] age, 60.6 [13.3] years; 3560 [76.0%] cancer, 842 [18.0%] diabetes, and 281 [6.0%] multiple sclerosis), 3813 (81.5%) self-reported having at least one COVID-19 vaccine. Unvaccinated status was associated with younger age, female sex, lower education and income, English as a second language, and residence in regional areas. Unvaccinated participants were more likely to report greater vaccine hesitancy and more negative perceptions toward vaccines. Disease-related vaccine concerns were associated with unvaccinated status and hesitancy, including greater complacency about COVID-19 infection, and concerns relating to vaccine efficacy and impact on their disease and/or treatment. This highlights the need to develop targeted strategies and education about COVID-19 vaccination to support medically vulnerable populations and health professionals.https://www.mdpi.com/2076-393X/10/6/851COVID-19vaccine hesitancycancerdiabetesmultiple sclerosis |
| spellingShingle | Daphne Day Lisa Grech Mike Nguyen Nathan Bain Alastair Kwok Sam Harris Hieu Chau Bryan Chan Richard Blennerhassett Louise Nott Nada Hamad Annette Tognela David Hoffman Amelia McCartney Kate Webber Jennifer Wong Craig Underhill Brett Sillars Antony Winkel Mark Savage Bao Sheng Loe Daniel Freeman Eva Segelov on behalf of the CANVACCS, DIABVACCS and MSVACCS Investigators Serious Underlying Medical Conditions and COVID-19 Vaccine Hesitancy: A Large Cross-Sectional Analysis from Australia Vaccines COVID-19 vaccine hesitancy cancer diabetes multiple sclerosis |
| title | Serious Underlying Medical Conditions and COVID-19 Vaccine Hesitancy: A Large Cross-Sectional Analysis from Australia |
| title_full | Serious Underlying Medical Conditions and COVID-19 Vaccine Hesitancy: A Large Cross-Sectional Analysis from Australia |
| title_fullStr | Serious Underlying Medical Conditions and COVID-19 Vaccine Hesitancy: A Large Cross-Sectional Analysis from Australia |
| title_full_unstemmed | Serious Underlying Medical Conditions and COVID-19 Vaccine Hesitancy: A Large Cross-Sectional Analysis from Australia |
| title_short | Serious Underlying Medical Conditions and COVID-19 Vaccine Hesitancy: A Large Cross-Sectional Analysis from Australia |
| title_sort | serious underlying medical conditions and covid 19 vaccine hesitancy a large cross sectional analysis from australia |
| topic | COVID-19 vaccine hesitancy cancer diabetes multiple sclerosis |
| url | https://www.mdpi.com/2076-393X/10/6/851 |
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