Virus-host interaction networks as new antiviral drug targets for IAV and SARS-CoV-2
Currently, SARS-CoV-2, especially the Omicron strain, is ravaging the world and even co-infecting human beings with IAV, which is a serious threat to human public health. As of yet, no specific antiviral drug has been discovered for SARS-CoV-2. This requires deeper understandings of the molecular me...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | Emerging Microbes and Infections |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2022.2071175 |
| _version_ | 1828195187911819264 |
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| author | Na Chen Baoge Zhang Lulu Deng Bing Liang Jihui Ping |
| author_facet | Na Chen Baoge Zhang Lulu Deng Bing Liang Jihui Ping |
| author_sort | Na Chen |
| collection | DOAJ |
| description | Currently, SARS-CoV-2, especially the Omicron strain, is ravaging the world and even co-infecting human beings with IAV, which is a serious threat to human public health. As of yet, no specific antiviral drug has been discovered for SARS-CoV-2. This requires deeper understandings of the molecular mechanisms of SARS-CoV-2-host interaction, to explore antiviral drug targets and provide theoretical basis for developing anti-SARS-CoV-2 drugs. This article discussed IAV, which has been comprehensively studied and is expected to provide the most important reference value for the SARS-CoV-2 study apart from members of the Coronaviridae family. We wish to establish a theoretical system for the studies on virus-host interaction. Previous studies have shown that host PRRs recognize RNAs of IAV or SARS-CoV-2 and then activate innate immune signaling pathways to induce the expression of host restriction factors, such as ISGs, to ultimately inhibit viral replication. Meanwhile, viruses have also evolved various regulatory mechanisms to antagonize host innate immunity at transcriptional, translational, post-translational modification, and epigenetic levels. Besides, viruses can hijack supportive host factors for their replication. Notably, the race between host antiviral innate immunity and viral antagonism of host innate immunity forms virus-host interaction networks. Additionally, the viral replication cycle is co-regulated by proteins, ncRNAs, sugars, lipids, hormones, and inorganic salts. Given this, we updated the mappings of antiviral drug targets based on virus-host interaction networks and proposed an innovative idea that virus-host interaction networks as new antiviral drug targets for IAV and SARS-CoV-2 from the perspectives of viral immunology and systems biology. |
| first_indexed | 2024-04-12T09:38:12Z |
| format | Article |
| id | doaj.art-d5605d63221e49c1a51486ff4f7acb05 |
| institution | Directory Open Access Journal |
| issn | 2222-1751 |
| language | English |
| last_indexed | 2024-04-12T09:38:12Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj.art-d5605d63221e49c1a51486ff4f7acb052022-12-22T03:38:10ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512022-12-011111371138910.1080/22221751.2022.2071175Virus-host interaction networks as new antiviral drug targets for IAV and SARS-CoV-2Na Chen0Baoge Zhang1Lulu Deng2Bing Liang3Jihui Ping4MOE Joint International Research Laboratory of Animal Health and Food Safety, Engineering Laboratory of Animal Immunity of Jiangsu Province, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of ChinaCollege of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of ChinaMOE Joint International Research Laboratory of Animal Health and Food Safety, Engineering Laboratory of Animal Immunity of Jiangsu Province, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of ChinaMOE Joint International Research Laboratory of Animal Health and Food Safety, Engineering Laboratory of Animal Immunity of Jiangsu Province, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of ChinaMOE Joint International Research Laboratory of Animal Health and Food Safety, Engineering Laboratory of Animal Immunity of Jiangsu Province, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of ChinaCurrently, SARS-CoV-2, especially the Omicron strain, is ravaging the world and even co-infecting human beings with IAV, which is a serious threat to human public health. As of yet, no specific antiviral drug has been discovered for SARS-CoV-2. This requires deeper understandings of the molecular mechanisms of SARS-CoV-2-host interaction, to explore antiviral drug targets and provide theoretical basis for developing anti-SARS-CoV-2 drugs. This article discussed IAV, which has been comprehensively studied and is expected to provide the most important reference value for the SARS-CoV-2 study apart from members of the Coronaviridae family. We wish to establish a theoretical system for the studies on virus-host interaction. Previous studies have shown that host PRRs recognize RNAs of IAV or SARS-CoV-2 and then activate innate immune signaling pathways to induce the expression of host restriction factors, such as ISGs, to ultimately inhibit viral replication. Meanwhile, viruses have also evolved various regulatory mechanisms to antagonize host innate immunity at transcriptional, translational, post-translational modification, and epigenetic levels. Besides, viruses can hijack supportive host factors for their replication. Notably, the race between host antiviral innate immunity and viral antagonism of host innate immunity forms virus-host interaction networks. Additionally, the viral replication cycle is co-regulated by proteins, ncRNAs, sugars, lipids, hormones, and inorganic salts. Given this, we updated the mappings of antiviral drug targets based on virus-host interaction networks and proposed an innovative idea that virus-host interaction networks as new antiviral drug targets for IAV and SARS-CoV-2 from the perspectives of viral immunology and systems biology.https://www.tandfonline.com/doi/10.1080/22221751.2022.2071175IAVSARS-CoV-2virus-host interactionsreplication cyclehost innate immunityantiviral drug targets |
| spellingShingle | Na Chen Baoge Zhang Lulu Deng Bing Liang Jihui Ping Virus-host interaction networks as new antiviral drug targets for IAV and SARS-CoV-2 Emerging Microbes and Infections IAV SARS-CoV-2 virus-host interactions replication cycle host innate immunity antiviral drug targets |
| title | Virus-host interaction networks as new antiviral drug targets for IAV and SARS-CoV-2 |
| title_full | Virus-host interaction networks as new antiviral drug targets for IAV and SARS-CoV-2 |
| title_fullStr | Virus-host interaction networks as new antiviral drug targets for IAV and SARS-CoV-2 |
| title_full_unstemmed | Virus-host interaction networks as new antiviral drug targets for IAV and SARS-CoV-2 |
| title_short | Virus-host interaction networks as new antiviral drug targets for IAV and SARS-CoV-2 |
| title_sort | virus host interaction networks as new antiviral drug targets for iav and sars cov 2 |
| topic | IAV SARS-CoV-2 virus-host interactions replication cycle host innate immunity antiviral drug targets |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2022.2071175 |
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