Pars Plana Vitrectomy Combined with Internal Limiting Membrane Peeling to Treat Persistent Macular Edema after Anti-Vascular Endothelial Growth Factor Treatment in Cases of Ischemic Central Retinal Vein Occlusion
Objective: To evaluate the efficacy of pars plana vitrectomy (PPV) combined with internal limiting membrane (ILM) peeling in cases of ischemic central retinal vein occlusion (CRVO) where macular edema (ME) persisted after anti-vascular endothelial growth factor (anti-VEGF) treatment. Methods: Fiftee...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2016-01-01
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| Series: | Case Reports in Ophthalmology |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/443322 |
| _version_ | 1818445619306430464 |
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| author | Yukari Shirakata Tomoyoshi Fujita Yuki Nakano Fumio Shiraga Akitaka Tsujikawa |
| author_facet | Yukari Shirakata Tomoyoshi Fujita Yuki Nakano Fumio Shiraga Akitaka Tsujikawa |
| author_sort | Yukari Shirakata |
| collection | DOAJ |
| description | Objective: To evaluate the efficacy of pars plana vitrectomy (PPV) combined with internal limiting membrane (ILM) peeling in cases of ischemic central retinal vein occlusion (CRVO) where macular edema (ME) persisted after anti-vascular endothelial growth factor (anti-VEGF) treatment. Methods: Fifteen eyes with ischemic CRVO-related ME were included in the study. Nine were treated with panretinal photocoagulation after initial examination. Anti-VEGF agents were injected intravitreally. Persistent ME was treated with PPV combined with ILM peeling. During surgery, laser photocoagulation was further applied to the non-perfused area. Results: Mean retinal thickness gradually decreased after surgery (p = 0.024 at 6 months), although visual acuity did not improve significantly during the follow-up period (14.7 ± 11.6 months). Neovascular glaucoma subsequently developed in three cases and a trabeculectomy was performed in one case. Conclusion: In eyes with ischemic CRVO, PPV combined with ILM peeling contributed to a reduction in persistent ME. However, there was no significant improvement in visual acuity. |
| first_indexed | 2024-12-14T19:34:42Z |
| format | Article |
| id | doaj.art-d56136c93f28460fb597e1d775b73ee5 |
| institution | Directory Open Access Journal |
| issn | 1663-2699 |
| language | English |
| last_indexed | 2024-12-14T19:34:42Z |
| publishDate | 2016-01-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Ophthalmology |
| spelling | doaj.art-d56136c93f28460fb597e1d775b73ee52022-12-21T22:49:57ZengKarger PublishersCase Reports in Ophthalmology1663-26992016-01-01711810.1159/000443322443322Pars Plana Vitrectomy Combined with Internal Limiting Membrane Peeling to Treat Persistent Macular Edema after Anti-Vascular Endothelial Growth Factor Treatment in Cases of Ischemic Central Retinal Vein OcclusionYukari ShirakataTomoyoshi FujitaYuki NakanoFumio ShiragaAkitaka TsujikawaObjective: To evaluate the efficacy of pars plana vitrectomy (PPV) combined with internal limiting membrane (ILM) peeling in cases of ischemic central retinal vein occlusion (CRVO) where macular edema (ME) persisted after anti-vascular endothelial growth factor (anti-VEGF) treatment. Methods: Fifteen eyes with ischemic CRVO-related ME were included in the study. Nine were treated with panretinal photocoagulation after initial examination. Anti-VEGF agents were injected intravitreally. Persistent ME was treated with PPV combined with ILM peeling. During surgery, laser photocoagulation was further applied to the non-perfused area. Results: Mean retinal thickness gradually decreased after surgery (p = 0.024 at 6 months), although visual acuity did not improve significantly during the follow-up period (14.7 ± 11.6 months). Neovascular glaucoma subsequently developed in three cases and a trabeculectomy was performed in one case. Conclusion: In eyes with ischemic CRVO, PPV combined with ILM peeling contributed to a reduction in persistent ME. However, there was no significant improvement in visual acuity.http://www.karger.com/Article/FullText/443322Anti-vascular endothelial growth factorCentral retinal vein occlusionInternal limiting membrane peelingMacular edemaPars plana vitrectomy |
| spellingShingle | Yukari Shirakata Tomoyoshi Fujita Yuki Nakano Fumio Shiraga Akitaka Tsujikawa Pars Plana Vitrectomy Combined with Internal Limiting Membrane Peeling to Treat Persistent Macular Edema after Anti-Vascular Endothelial Growth Factor Treatment in Cases of Ischemic Central Retinal Vein Occlusion Case Reports in Ophthalmology Anti-vascular endothelial growth factor Central retinal vein occlusion Internal limiting membrane peeling Macular edema Pars plana vitrectomy |
| title | Pars Plana Vitrectomy Combined with Internal Limiting Membrane Peeling to Treat Persistent Macular Edema after Anti-Vascular Endothelial Growth Factor Treatment in Cases of Ischemic Central Retinal Vein Occlusion |
| title_full | Pars Plana Vitrectomy Combined with Internal Limiting Membrane Peeling to Treat Persistent Macular Edema after Anti-Vascular Endothelial Growth Factor Treatment in Cases of Ischemic Central Retinal Vein Occlusion |
| title_fullStr | Pars Plana Vitrectomy Combined with Internal Limiting Membrane Peeling to Treat Persistent Macular Edema after Anti-Vascular Endothelial Growth Factor Treatment in Cases of Ischemic Central Retinal Vein Occlusion |
| title_full_unstemmed | Pars Plana Vitrectomy Combined with Internal Limiting Membrane Peeling to Treat Persistent Macular Edema after Anti-Vascular Endothelial Growth Factor Treatment in Cases of Ischemic Central Retinal Vein Occlusion |
| title_short | Pars Plana Vitrectomy Combined with Internal Limiting Membrane Peeling to Treat Persistent Macular Edema after Anti-Vascular Endothelial Growth Factor Treatment in Cases of Ischemic Central Retinal Vein Occlusion |
| title_sort | pars plana vitrectomy combined with internal limiting membrane peeling to treat persistent macular edema after anti vascular endothelial growth factor treatment in cases of ischemic central retinal vein occlusion |
| topic | Anti-vascular endothelial growth factor Central retinal vein occlusion Internal limiting membrane peeling Macular edema Pars plana vitrectomy |
| url | http://www.karger.com/Article/FullText/443322 |
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