Associations between Vitamin D Status and Polysomnographic Parameters in Adults with Obstructive Sleep Apnea
Vitamin D deficiency (VDD) may be associated with obstructive sleep apnea (OSA) presence and is more pronounced with increasing OSA severity; however, the relationship between these two entities remains unclear. This was a cross-sectional study among 262 adults with in-hospital-attended polysomnogra...
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MDPI AG
2024-02-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/14/2/275 |
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| author | Ioanna Kechribari Meropi D. Kontogianni Michael Georgoulis Kallirroi Lamprou Eleni Perraki Emmanouil Vagiakis Nikos Yiannakouris |
| author_facet | Ioanna Kechribari Meropi D. Kontogianni Michael Georgoulis Kallirroi Lamprou Eleni Perraki Emmanouil Vagiakis Nikos Yiannakouris |
| author_sort | Ioanna Kechribari |
| collection | DOAJ |
| description | Vitamin D deficiency (VDD) may be associated with obstructive sleep apnea (OSA) presence and is more pronounced with increasing OSA severity; however, the relationship between these two entities remains unclear. This was a cross-sectional study among 262 adults with in-hospital-attended polysomnography-diagnosed OSA and no additional major comorbidities, aiming to explore possible associations between serum 25-hydroxyvitamin D [25(OH)D] levels and polysomnographic parameters. Data on demographics, medical history, anthropometric indices, and lifestyle habits were collected at enrolment. Serum 25(OH)D was evaluated using chemiluminescence, with VDD defined as 25(OH)D < 20 ng/mL. VDD was observed in 63% of the participants. Serum 25(OH)D correlated negatively with apnea–hypopnea index and other polysomnographic indices (all <i>p</i> < 0.05). In logistic regression analysis, adjusting for age, sex, smoking, body mass index, physical activity, dietary vitamin D intake, and season of blood sampling, serum 25(OH)D was associated with lower odds of severe OSA [odds ratio (95% confidence interval): 0.94 (0.90–0.98)]. In the same multivariate model, VDD was associated with ~threefold higher odds of severe OSA [2.75 (1.38–5.48)]. In stratified analyses, VDD predicted OSA severity in the group of participants ≥50 y [3.54 (1.29–9.68)] and among those with body mass index ≥ 30 kg/m<sup>2</sup> [3.38 (1.52–7.52)], but not in the younger and non-obese adults. This study provides further evidence of an inverse association between vitamin D levels and OSA severity and underscores the importance of considering vitamin D status as a potential modifiable factor in the comprehensive management of OSA. |
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| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-07T22:24:07Z |
| publishDate | 2024-02-01 |
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| spelling | doaj.art-d563419c2e2e4b2cb182fa4a4b0585792024-02-23T15:24:49ZengMDPI AGLife2075-17292024-02-0114227510.3390/life14020275Associations between Vitamin D Status and Polysomnographic Parameters in Adults with Obstructive Sleep ApneaIoanna Kechribari0Meropi D. Kontogianni1Michael Georgoulis2Kallirroi Lamprou3Eleni Perraki4Emmanouil Vagiakis5Nikos Yiannakouris6Department of Nutrition and Dietetics, School of Health Sciences and Education, Harokopio University of Athens, 17676 Athens, GreeceDepartment of Nutrition and Dietetics, School of Health Sciences and Education, Harokopio University of Athens, 17676 Athens, GreeceDepartment of Nutrition and Dietetics, School of Health Sciences and Education, Harokopio University of Athens, 17676 Athens, GreeceCenter of Sleep Disorders, 1st Department of Critical Care, Evangelismos General Hospital, 10676 Athens, GreeceCenter of Sleep Disorders, 1st Department of Critical Care, Evangelismos General Hospital, 10676 Athens, GreeceCenter of Sleep Disorders, 1st Department of Critical Care, Evangelismos General Hospital, 10676 Athens, GreeceDepartment of Nutrition and Dietetics, School of Health Sciences and Education, Harokopio University of Athens, 17676 Athens, GreeceVitamin D deficiency (VDD) may be associated with obstructive sleep apnea (OSA) presence and is more pronounced with increasing OSA severity; however, the relationship between these two entities remains unclear. This was a cross-sectional study among 262 adults with in-hospital-attended polysomnography-diagnosed OSA and no additional major comorbidities, aiming to explore possible associations between serum 25-hydroxyvitamin D [25(OH)D] levels and polysomnographic parameters. Data on demographics, medical history, anthropometric indices, and lifestyle habits were collected at enrolment. Serum 25(OH)D was evaluated using chemiluminescence, with VDD defined as 25(OH)D < 20 ng/mL. VDD was observed in 63% of the participants. Serum 25(OH)D correlated negatively with apnea–hypopnea index and other polysomnographic indices (all <i>p</i> < 0.05). In logistic regression analysis, adjusting for age, sex, smoking, body mass index, physical activity, dietary vitamin D intake, and season of blood sampling, serum 25(OH)D was associated with lower odds of severe OSA [odds ratio (95% confidence interval): 0.94 (0.90–0.98)]. In the same multivariate model, VDD was associated with ~threefold higher odds of severe OSA [2.75 (1.38–5.48)]. In stratified analyses, VDD predicted OSA severity in the group of participants ≥50 y [3.54 (1.29–9.68)] and among those with body mass index ≥ 30 kg/m<sup>2</sup> [3.38 (1.52–7.52)], but not in the younger and non-obese adults. This study provides further evidence of an inverse association between vitamin D levels and OSA severity and underscores the importance of considering vitamin D status as a potential modifiable factor in the comprehensive management of OSA.https://www.mdpi.com/2075-1729/14/2/275obstructive sleep apneaapnea-hypopnea index25-hydroxyvitamin Dvitamin D deficiency |
| spellingShingle | Ioanna Kechribari Meropi D. Kontogianni Michael Georgoulis Kallirroi Lamprou Eleni Perraki Emmanouil Vagiakis Nikos Yiannakouris Associations between Vitamin D Status and Polysomnographic Parameters in Adults with Obstructive Sleep Apnea Life obstructive sleep apnea apnea-hypopnea index 25-hydroxyvitamin D vitamin D deficiency |
| title | Associations between Vitamin D Status and Polysomnographic Parameters in Adults with Obstructive Sleep Apnea |
| title_full | Associations between Vitamin D Status and Polysomnographic Parameters in Adults with Obstructive Sleep Apnea |
| title_fullStr | Associations between Vitamin D Status and Polysomnographic Parameters in Adults with Obstructive Sleep Apnea |
| title_full_unstemmed | Associations between Vitamin D Status and Polysomnographic Parameters in Adults with Obstructive Sleep Apnea |
| title_short | Associations between Vitamin D Status and Polysomnographic Parameters in Adults with Obstructive Sleep Apnea |
| title_sort | associations between vitamin d status and polysomnographic parameters in adults with obstructive sleep apnea |
| topic | obstructive sleep apnea apnea-hypopnea index 25-hydroxyvitamin D vitamin D deficiency |
| url | https://www.mdpi.com/2075-1729/14/2/275 |
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