Differential involvement of hippocampal angiotensin 1 receptors in learning and memory processes in bulbectomized rats
There is conflicting evidence regarding the effect of AT1 receptor antagonists on learning and memory processes. The effects of angiotensin II and losartan administration into CA1 hippocampal area on the avoidance performance in olfactory bulbectomized (OBX) rats using active avoidance (shuttle box)...
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| Format: | Article |
| Language: | English |
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Ion Motofei, Carol Davila University
2016-04-01
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| Series: | Journal of Mind and Medical Sciences |
| Subjects: | |
| Online Access: | http://scholar.valpo.edu/cgi/viewcontent.cgi?article=1036&context=jmms |
| _version_ | 1830487685688459264 |
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| author | Tashev E. Roman Margarita S. Ivanova Stiliana P. Belcheva Iren P. Belcheva |
| author_facet | Tashev E. Roman Margarita S. Ivanova Stiliana P. Belcheva Iren P. Belcheva |
| author_sort | Tashev E. Roman |
| collection | DOAJ |
| description | There is conflicting evidence regarding the effect of AT1 receptor antagonists on learning and memory processes. The effects of angiotensin II and losartan administration into CA1 hippocampal area on the avoidance performance in olfactory bulbectomized (OBX) rats using active avoidance (shuttle box) test and passive avoidance (step through) test were investigated. Rats were microinjected unilaterally through implanted guide cannulas into the CA1 area of the dorsal hippocampus and the drugs were administered separately, 5 minutes before each training session. The microinjections of losartan into the left, but not the right CA1 hippocampal area improved the acquisition and retention of active and passive avoidance learning, thus suggesting dependence on the side of injection. The unilateral (left or right) administration of angiotensin II did not significantly affect the performance of OBX rats in the avoidance tasks. A differential distribution of the AT1 receptors in the left and right hemisphere could contribute for the asymmetry in the behavioral effects of the AT receptor antagonist. |
| first_indexed | 2024-12-21T19:05:05Z |
| format | Article |
| id | doaj.art-d563631f7f8647aeba34c2b8742bb308 |
| institution | Directory Open Access Journal |
| issn | 2392-7674 2392-7674 |
| language | English |
| last_indexed | 2024-12-21T19:05:05Z |
| publishDate | 2016-04-01 |
| publisher | Ion Motofei, Carol Davila University |
| record_format | Article |
| series | Journal of Mind and Medical Sciences |
| spelling | doaj.art-d563631f7f8647aeba34c2b8742bb3082022-12-21T18:53:22ZengIon Motofei, Carol Davila UniversityJournal of Mind and Medical Sciences2392-76742392-76742016-04-01313954Differential involvement of hippocampal angiotensin 1 receptors in learning and memory processes in bulbectomized ratsTashev E. Roman0Margarita S. Ivanova1Stiliana P. Belcheva2Iren P. Belcheva3Bulgarian Academy of Sciences, Institute of Neurobiology, Department of Behavior Neurobiology, Department of Pathophysiology, Medical University of SofiaMedical University, Department of Physiology and PathophysiologyBulgarian Academy of Sciences, Institute of Neurobiology, Department of Behavior Neurobiology, Faculty of Pre-School and Primary School Education SU Sv. Kl. OhridskyBulgarian Academy of Sciences, Institute of Neurobiology, Department of Behavior NeurobiologyThere is conflicting evidence regarding the effect of AT1 receptor antagonists on learning and memory processes. The effects of angiotensin II and losartan administration into CA1 hippocampal area on the avoidance performance in olfactory bulbectomized (OBX) rats using active avoidance (shuttle box) test and passive avoidance (step through) test were investigated. Rats were microinjected unilaterally through implanted guide cannulas into the CA1 area of the dorsal hippocampus and the drugs were administered separately, 5 minutes before each training session. The microinjections of losartan into the left, but not the right CA1 hippocampal area improved the acquisition and retention of active and passive avoidance learning, thus suggesting dependence on the side of injection. The unilateral (left or right) administration of angiotensin II did not significantly affect the performance of OBX rats in the avoidance tasks. A differential distribution of the AT1 receptors in the left and right hemisphere could contribute for the asymmetry in the behavioral effects of the AT receptor antagonist.http://scholar.valpo.edu/cgi/viewcontent.cgi?article=1036&context=jmmsangiotensin IIlosartanlearningmemoryasymmetryhippocampusolfactory bulbectomy |
| spellingShingle | Tashev E. Roman Margarita S. Ivanova Stiliana P. Belcheva Iren P. Belcheva Differential involvement of hippocampal angiotensin 1 receptors in learning and memory processes in bulbectomized rats Journal of Mind and Medical Sciences angiotensin II losartan learning memory asymmetry hippocampus olfactory bulbectomy |
| title | Differential involvement of hippocampal angiotensin 1 receptors in learning and memory processes in bulbectomized rats |
| title_full | Differential involvement of hippocampal angiotensin 1 receptors in learning and memory processes in bulbectomized rats |
| title_fullStr | Differential involvement of hippocampal angiotensin 1 receptors in learning and memory processes in bulbectomized rats |
| title_full_unstemmed | Differential involvement of hippocampal angiotensin 1 receptors in learning and memory processes in bulbectomized rats |
| title_short | Differential involvement of hippocampal angiotensin 1 receptors in learning and memory processes in bulbectomized rats |
| title_sort | differential involvement of hippocampal angiotensin 1 receptors in learning and memory processes in bulbectomized rats |
| topic | angiotensin II losartan learning memory asymmetry hippocampus olfactory bulbectomy |
| url | http://scholar.valpo.edu/cgi/viewcontent.cgi?article=1036&context=jmms |
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