Correlation of Biomarkers with Endoscopic Score: Ulcerative Colitis Endoscopic Index of Severity (UCEIS) in Patients with Ulcerative Colitis in Remission
<i>Background and Objectives:</i> Ulcerative colitis is a disease with an unpredictable evolution, often highlighted endoscopically, that is associated with persistent inflammation affecting the patient’s quality of life. An attempt was made to discover surrogate markers to evaluate the...
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MDPI AG
2020-12-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/57/1/31 |
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| author | Corina Silvia Pop Petruta Violeta Filip Sorina Laura Diaconu Clara Matei Florentina Furtunescu |
| author_facet | Corina Silvia Pop Petruta Violeta Filip Sorina Laura Diaconu Clara Matei Florentina Furtunescu |
| author_sort | Corina Silvia Pop |
| collection | DOAJ |
| description | <i>Background and Objectives:</i> Ulcerative colitis is a disease with an unpredictable evolution, often highlighted endoscopically, that is associated with persistent inflammation affecting the patient’s quality of life. An attempt was made to discover surrogate markers to evaluate the endoscopic remission of the disease in order to increase the patient’s quality of life and also their adherence to the treatment and monitoring plan. One such marker is fecal calprotectin (FC). To confirm the correlation between biomarkers and endoscopic disease activity and to define the optimal cut off value to detect clinical and endoscopic remission in a center of Romania. <i>Materials and Methods: </i> This was a prospective study that included 59 patients diagnosed with ulcerative colitis at the Department of Internal Medicine III, University Emergency Hospital of Bucharest. Patients had fecal calprotectin measurements and colonoscopy/rectosigmoidoscopy performed during baseline, 6 and 12 months. For endoscopic activity the Ulcerative Colitis Endoscopic Index of Severity (UCEIS) was used. <i>Results:</i> During the study, relapses have occurred in 35.6% of patients, the median age was 47 years (21–77). During the study, the FC measurement was significantly increased at 3 months (median, range µg/g; 715, 14–4000) and at 6 months (median, range µg/g; 650, 4.5–3000) (<i>p</i> ≤ 0.05). Another inflammatory biomarker studied was CRP, which showed increased values at 3 months (median, range, mg/dL; 1.86, 0.14–58.9), at 6 months (median, range, mg/dL; 2.36, 0.12–45.8) and at 9 months (median, range, mg/dL; 2, 0.12–25.9) compared to the baseline (<i>p</i> = 0.01). Patients with recurrence of the disease also associated an increase in the values of clinical evaluation scores (SCCAI; <i>p</i> = 0.00001), but also endoscopic (UCEIS; <i>p</i> = 0.0006) <i>Conclusion:</i> A relapse is associated independently with younger age, the extension of the disease (E2-E3), increased FC level, C reactive protein, hemoglobin concentration, SCCAI index and UCEIS score. |
| first_indexed | 2024-03-09T22:09:49Z |
| format | Article |
| id | doaj.art-d5638024bea0484f9c6c8f3d83f4cfbc |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-09T22:09:49Z |
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| spelling | doaj.art-d5638024bea0484f9c6c8f3d83f4cfbc2023-11-23T19:34:14ZengMDPI AGMedicina1010-660X1648-91442020-12-015713110.3390/medicina57010031Correlation of Biomarkers with Endoscopic Score: Ulcerative Colitis Endoscopic Index of Severity (UCEIS) in Patients with Ulcerative Colitis in RemissionCorina Silvia Pop0Petruta Violeta Filip1Sorina Laura Diaconu2Clara Matei3Florentina Furtunescu4Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Internal Medicine and Gastroenterology, University Emergency Hospital of Bucharest, 050098 Bucharest, RomaniaCarol Davila University of Medicine and Pharmacy, 020021 Bucharest, RomaniaCarol Davila University of Medicine and Pharmacy, 020021 Bucharest, RomaniaCarol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania<i>Background and Objectives:</i> Ulcerative colitis is a disease with an unpredictable evolution, often highlighted endoscopically, that is associated with persistent inflammation affecting the patient’s quality of life. An attempt was made to discover surrogate markers to evaluate the endoscopic remission of the disease in order to increase the patient’s quality of life and also their adherence to the treatment and monitoring plan. One such marker is fecal calprotectin (FC). To confirm the correlation between biomarkers and endoscopic disease activity and to define the optimal cut off value to detect clinical and endoscopic remission in a center of Romania. <i>Materials and Methods: </i> This was a prospective study that included 59 patients diagnosed with ulcerative colitis at the Department of Internal Medicine III, University Emergency Hospital of Bucharest. Patients had fecal calprotectin measurements and colonoscopy/rectosigmoidoscopy performed during baseline, 6 and 12 months. For endoscopic activity the Ulcerative Colitis Endoscopic Index of Severity (UCEIS) was used. <i>Results:</i> During the study, relapses have occurred in 35.6% of patients, the median age was 47 years (21–77). During the study, the FC measurement was significantly increased at 3 months (median, range µg/g; 715, 14–4000) and at 6 months (median, range µg/g; 650, 4.5–3000) (<i>p</i> ≤ 0.05). Another inflammatory biomarker studied was CRP, which showed increased values at 3 months (median, range, mg/dL; 1.86, 0.14–58.9), at 6 months (median, range, mg/dL; 2.36, 0.12–45.8) and at 9 months (median, range, mg/dL; 2, 0.12–25.9) compared to the baseline (<i>p</i> = 0.01). Patients with recurrence of the disease also associated an increase in the values of clinical evaluation scores (SCCAI; <i>p</i> = 0.00001), but also endoscopic (UCEIS; <i>p</i> = 0.0006) <i>Conclusion:</i> A relapse is associated independently with younger age, the extension of the disease (E2-E3), increased FC level, C reactive protein, hemoglobin concentration, SCCAI index and UCEIS score.https://www.mdpi.com/1648-9144/57/1/31ulcerative colitisfecal calprotectinC-reactive proteinhemoglobin concentrationendoscopic remission |
| spellingShingle | Corina Silvia Pop Petruta Violeta Filip Sorina Laura Diaconu Clara Matei Florentina Furtunescu Correlation of Biomarkers with Endoscopic Score: Ulcerative Colitis Endoscopic Index of Severity (UCEIS) in Patients with Ulcerative Colitis in Remission Medicina ulcerative colitis fecal calprotectin C-reactive protein hemoglobin concentration endoscopic remission |
| title | Correlation of Biomarkers with Endoscopic Score: Ulcerative Colitis Endoscopic Index of Severity (UCEIS) in Patients with Ulcerative Colitis in Remission |
| title_full | Correlation of Biomarkers with Endoscopic Score: Ulcerative Colitis Endoscopic Index of Severity (UCEIS) in Patients with Ulcerative Colitis in Remission |
| title_fullStr | Correlation of Biomarkers with Endoscopic Score: Ulcerative Colitis Endoscopic Index of Severity (UCEIS) in Patients with Ulcerative Colitis in Remission |
| title_full_unstemmed | Correlation of Biomarkers with Endoscopic Score: Ulcerative Colitis Endoscopic Index of Severity (UCEIS) in Patients with Ulcerative Colitis in Remission |
| title_short | Correlation of Biomarkers with Endoscopic Score: Ulcerative Colitis Endoscopic Index of Severity (UCEIS) in Patients with Ulcerative Colitis in Remission |
| title_sort | correlation of biomarkers with endoscopic score ulcerative colitis endoscopic index of severity uceis in patients with ulcerative colitis in remission |
| topic | ulcerative colitis fecal calprotectin C-reactive protein hemoglobin concentration endoscopic remission |
| url | https://www.mdpi.com/1648-9144/57/1/31 |
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