Gene Therapy for Neurodegenerative Disease: Clinical Potential and Directions
The pathogenesis of neurodegenerative diseases (NDDs) is complex and diverse. Over the decades, our understanding of NDD has been limited to pathological features. However, recent advances in gene sequencing have facilitated elucidation of NDD at a deeper level. Gene editing techniques have uncovere...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-06-01
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| Series: | Frontiers in Molecular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnmol.2021.618171/full |
| _version_ | 1818668855392731136 |
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| author | Xiaolin Zhu Yu Zhang Xin Yang Chunyan Hao Hubin Duan Hubin Duan |
| author_facet | Xiaolin Zhu Yu Zhang Xin Yang Chunyan Hao Hubin Duan Hubin Duan |
| author_sort | Xiaolin Zhu |
| collection | DOAJ |
| description | The pathogenesis of neurodegenerative diseases (NDDs) is complex and diverse. Over the decades, our understanding of NDD has been limited to pathological features. However, recent advances in gene sequencing have facilitated elucidation of NDD at a deeper level. Gene editing techniques have uncovered new genetic links to phenotypes, promoted the development of novel treatment strategies and equipped researchers with further means to construct effective cell and animal models. The current review describes the history of evolution of gene editing tools, with the aim of improving overall understanding of this technology, and focuses on the four most common NDD disorders to demonstrate the potential future applications and research directions of gene editing. |
| first_indexed | 2024-12-17T06:42:57Z |
| format | Article |
| id | doaj.art-d564a11c3a234689bab16ac967656ab3 |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-12-17T06:42:57Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-d564a11c3a234689bab16ac967656ab32022-12-21T21:59:48ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992021-06-011410.3389/fnmol.2021.618171618171Gene Therapy for Neurodegenerative Disease: Clinical Potential and DirectionsXiaolin Zhu0Yu Zhang1Xin Yang2Chunyan Hao3Hubin Duan4Hubin Duan5Department of Neurosurgery, First Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Neurosurgery, First Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Neurosurgery, First Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Geriatrics, First Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Neurosurgery, First Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Neurosurgery, Lvliang People’s Hospital, Lvliang, ChinaThe pathogenesis of neurodegenerative diseases (NDDs) is complex and diverse. Over the decades, our understanding of NDD has been limited to pathological features. However, recent advances in gene sequencing have facilitated elucidation of NDD at a deeper level. Gene editing techniques have uncovered new genetic links to phenotypes, promoted the development of novel treatment strategies and equipped researchers with further means to construct effective cell and animal models. The current review describes the history of evolution of gene editing tools, with the aim of improving overall understanding of this technology, and focuses on the four most common NDD disorders to demonstrate the potential future applications and research directions of gene editing.https://www.frontiersin.org/articles/10.3389/fnmol.2021.618171/fullgene editingneurodegenerative diseaseAlzheimer’s diseaseParkinson’s diseaseHuntington’s diseaseamyotrophic lateral sclerosis |
| spellingShingle | Xiaolin Zhu Yu Zhang Xin Yang Chunyan Hao Hubin Duan Hubin Duan Gene Therapy for Neurodegenerative Disease: Clinical Potential and Directions Frontiers in Molecular Neuroscience gene editing neurodegenerative disease Alzheimer’s disease Parkinson’s disease Huntington’s disease amyotrophic lateral sclerosis |
| title | Gene Therapy for Neurodegenerative Disease: Clinical Potential and Directions |
| title_full | Gene Therapy for Neurodegenerative Disease: Clinical Potential and Directions |
| title_fullStr | Gene Therapy for Neurodegenerative Disease: Clinical Potential and Directions |
| title_full_unstemmed | Gene Therapy for Neurodegenerative Disease: Clinical Potential and Directions |
| title_short | Gene Therapy for Neurodegenerative Disease: Clinical Potential and Directions |
| title_sort | gene therapy for neurodegenerative disease clinical potential and directions |
| topic | gene editing neurodegenerative disease Alzheimer’s disease Parkinson’s disease Huntington’s disease amyotrophic lateral sclerosis |
| url | https://www.frontiersin.org/articles/10.3389/fnmol.2021.618171/full |
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