Epigenetic Regulation of the Neural Transcriptome and Alcohol Interference During Development
Alcohol intoxicated cells broadly alter their metabolites–– among them methyl and acetic acid can alter the DNA and histone epigenetic codes. Together with the promiscuous effect of alcohol on enzyme activities (including DNA methyltransferases) and the downstream effect on microRNA and transposable...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-08-01
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| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00285/full |
| _version_ | 1818306944160497664 |
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| author | Marisol eResendiz Stephen eMason Feng C. Zhou Chiao-Ling eLo |
| author_facet | Marisol eResendiz Stephen eMason Feng C. Zhou Chiao-Ling eLo |
| author_sort | Marisol eResendiz |
| collection | DOAJ |
| description | Alcohol intoxicated cells broadly alter their metabolites–– among them methyl and acetic acid can alter the DNA and histone epigenetic codes. Together with the promiscuous effect of alcohol on enzyme activities (including DNA methyltransferases) and the downstream effect on microRNA and transposable elements, alcohol is well placed to affect intrinsic transcriptional programs of developing cells. Considering that the developmental consequences of early alcohol exposure so profoundly affect neural systems, it is not unfounded to reason that alcohol exploits transcriptional regulators to challenge canonical gene expression and in effect, intrinsic developmental pathways to achieve widespread damage in the developing nervous system. To fully evaluate the role of epigenetic regulation in alcohol-related developmental disease, it is important to first gather the targets of epigenetic players in neurodevelopmental models. Here, we attempt to review the cellular and genomic windows of opportunity for alcohol to act on intrinsic neurodevelopmental programs. We also discuss some established targets of fetal alcohol exposure and propose pathways for future study. Overall, this review hopes to illustrate the known epigenetic program and its alterations in normal neural stem cell development and further, aims to depict how alcohol, through neuroepigenetics, may lead to neurodevelopmental deficits observed in fetal alcohol spectrum disorders. |
| first_indexed | 2024-12-13T06:50:31Z |
| format | Article |
| id | doaj.art-d564b948b94242ea913bc9a309b6bbab |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-13T06:50:31Z |
| publishDate | 2014-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-d564b948b94242ea913bc9a309b6bbab2022-12-21T23:56:09ZengFrontiers Media S.A.Frontiers in Genetics1664-80212014-08-01510.3389/fgene.2014.00285102502Epigenetic Regulation of the Neural Transcriptome and Alcohol Interference During DevelopmentMarisol eResendiz0Stephen eMason1Feng C. Zhou2Chiao-Ling eLo3Indiana University School of MedicineIndiana University School of MedicineIndiana University School of MedicineIndiana University School of MedicineAlcohol intoxicated cells broadly alter their metabolites–– among them methyl and acetic acid can alter the DNA and histone epigenetic codes. Together with the promiscuous effect of alcohol on enzyme activities (including DNA methyltransferases) and the downstream effect on microRNA and transposable elements, alcohol is well placed to affect intrinsic transcriptional programs of developing cells. Considering that the developmental consequences of early alcohol exposure so profoundly affect neural systems, it is not unfounded to reason that alcohol exploits transcriptional regulators to challenge canonical gene expression and in effect, intrinsic developmental pathways to achieve widespread damage in the developing nervous system. To fully evaluate the role of epigenetic regulation in alcohol-related developmental disease, it is important to first gather the targets of epigenetic players in neurodevelopmental models. Here, we attempt to review the cellular and genomic windows of opportunity for alcohol to act on intrinsic neurodevelopmental programs. We also discuss some established targets of fetal alcohol exposure and propose pathways for future study. Overall, this review hopes to illustrate the known epigenetic program and its alterations in normal neural stem cell development and further, aims to depict how alcohol, through neuroepigenetics, may lead to neurodevelopmental deficits observed in fetal alcohol spectrum disorders.http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00285/fullepigeneticsgene regulationFASDgene-environment interactionneural developmentneuroepigenetics |
| spellingShingle | Marisol eResendiz Stephen eMason Feng C. Zhou Chiao-Ling eLo Epigenetic Regulation of the Neural Transcriptome and Alcohol Interference During Development Frontiers in Genetics epigenetics gene regulation FASD gene-environment interaction neural development neuroepigenetics |
| title | Epigenetic Regulation of the Neural Transcriptome and Alcohol Interference During Development |
| title_full | Epigenetic Regulation of the Neural Transcriptome and Alcohol Interference During Development |
| title_fullStr | Epigenetic Regulation of the Neural Transcriptome and Alcohol Interference During Development |
| title_full_unstemmed | Epigenetic Regulation of the Neural Transcriptome and Alcohol Interference During Development |
| title_short | Epigenetic Regulation of the Neural Transcriptome and Alcohol Interference During Development |
| title_sort | epigenetic regulation of the neural transcriptome and alcohol interference during development |
| topic | epigenetics gene regulation FASD gene-environment interaction neural development neuroepigenetics |
| url | http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00285/full |
| work_keys_str_mv | AT marisoleresendiz epigeneticregulationoftheneuraltranscriptomeandalcoholinterferenceduringdevelopment AT stephenemason epigeneticregulationoftheneuraltranscriptomeandalcoholinterferenceduringdevelopment AT fengczhou epigeneticregulationoftheneuraltranscriptomeandalcoholinterferenceduringdevelopment AT chiaolingelo epigeneticregulationoftheneuraltranscriptomeandalcoholinterferenceduringdevelopment |