Model of Pathological Collagen Mineralization Based on Spine Ligament Calcification
The aim of the study was to determine the time of mineral growth in human spine ligaments using a mathematical model. The study was based on our previous research in which the physicochemical analysis and computed microtomography measurements of deposits in ligamenta flava were performed. Hydroxyapa...
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MDPI AG
2020-05-01
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| Online Access: | https://www.mdpi.com/1996-1944/13/9/2130 |
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| author | Sylwia Orzechowska Renata Świsłocka Włodzimierz Lewandowski |
| author_facet | Sylwia Orzechowska Renata Świsłocka Włodzimierz Lewandowski |
| author_sort | Sylwia Orzechowska |
| collection | DOAJ |
| description | The aim of the study was to determine the time of mineral growth in human spine ligaments using a mathematical model. The study was based on our previous research in which the physicochemical analysis and computed microtomography measurements of deposits in ligamenta flava were performed. Hydroxyapatite-like mineral (HAP) constituted the mineral phase in ligament samples, in two samples calcium pyrophosphate dehydrate (CPPD) was confirmed. The micro-damage of collagen fibrils in the soft tissue is the crystallization center. The growth of the mineral nucleus is a result of the calcium ions deposition on the nucleus surface. Considering the calcium ions, the main component of HAP, it is possible to describe the grain growth using a diffusion model. The model calculations showed that the growth time of CPPD grains was ca. a month to 6 years, and for HAP grains >4 years for the young and >5.5 years for the elderly patients. The growth time of minerals with a radius >400 μm was relatively short and impossible to identify by medical imaging techniques. The change of growth rate was the largest for HAP deposits. The mineral growth time can provide valuable information for understanding the calcification mechanism, may be helpful in future experiments, as well as useful in estimating the time of calcification appearance. |
| first_indexed | 2024-03-10T20:02:48Z |
| format | Article |
| id | doaj.art-d5650842f13f4d929e7902985d9c9356 |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-10T20:02:48Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-d5650842f13f4d929e7902985d9c93562023-11-19T23:27:50ZengMDPI AGMaterials1996-19442020-05-01139213010.3390/ma13092130Model of Pathological Collagen Mineralization Based on Spine Ligament CalcificationSylwia Orzechowska0Renata Świsłocka1Włodzimierz Lewandowski2M. Smoluchowski Institute of Physics, Jagiellonian University, Łojasiewicza 11, 30-348 Kraków, PolandDepartment of Chemistry, Biology and Biotechnology, Bialystok University of Technology, 15-351 Białystok, PolandDepartment of Chemistry, Biology and Biotechnology, Bialystok University of Technology, 15-351 Białystok, PolandThe aim of the study was to determine the time of mineral growth in human spine ligaments using a mathematical model. The study was based on our previous research in which the physicochemical analysis and computed microtomography measurements of deposits in ligamenta flava were performed. Hydroxyapatite-like mineral (HAP) constituted the mineral phase in ligament samples, in two samples calcium pyrophosphate dehydrate (CPPD) was confirmed. The micro-damage of collagen fibrils in the soft tissue is the crystallization center. The growth of the mineral nucleus is a result of the calcium ions deposition on the nucleus surface. Considering the calcium ions, the main component of HAP, it is possible to describe the grain growth using a diffusion model. The model calculations showed that the growth time of CPPD grains was ca. a month to 6 years, and for HAP grains >4 years for the young and >5.5 years for the elderly patients. The growth time of minerals with a radius >400 μm was relatively short and impossible to identify by medical imaging techniques. The change of growth rate was the largest for HAP deposits. The mineral growth time can provide valuable information for understanding the calcification mechanism, may be helpful in future experiments, as well as useful in estimating the time of calcification appearance.https://www.mdpi.com/1996-1944/13/9/2130calcificationcollagencomputed microtomographymineralization modelhydroxyapatiteligamenta flava |
| spellingShingle | Sylwia Orzechowska Renata Świsłocka Włodzimierz Lewandowski Model of Pathological Collagen Mineralization Based on Spine Ligament Calcification Materials calcification collagen computed microtomography mineralization model hydroxyapatite ligamenta flava |
| title | Model of Pathological Collagen Mineralization Based on Spine Ligament Calcification |
| title_full | Model of Pathological Collagen Mineralization Based on Spine Ligament Calcification |
| title_fullStr | Model of Pathological Collagen Mineralization Based on Spine Ligament Calcification |
| title_full_unstemmed | Model of Pathological Collagen Mineralization Based on Spine Ligament Calcification |
| title_short | Model of Pathological Collagen Mineralization Based on Spine Ligament Calcification |
| title_sort | model of pathological collagen mineralization based on spine ligament calcification |
| topic | calcification collagen computed microtomography mineralization model hydroxyapatite ligamenta flava |
| url | https://www.mdpi.com/1996-1944/13/9/2130 |
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