Chronic bullous disease of childhood with IgG predominance: What is the locus standi?
Linear IgA disease (LAD) is an acquired, autoimmune, subepidermal, blistering disease, characterized by linear deposition of IgA along the dermoepidermal junction on immunofluorescence. Some cases known as ′mixed immunobullous disease′ show weak staining with other immune reactants like IgG, IgM or...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2012-01-01
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| Series: | Indian Journal of Dermatology |
| Subjects: | |
| Online Access: | http://www.e-ijd.org/article.asp?issn=0019-5154;year=2012;volume=57;issue=4;spage=285;epage=287;aulast=Haneef |
| _version_ | 1818460244863352832 |
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| author | Nayeem Sadath Haneef S Ramachandra Arun Kumar Metta L Srujana |
| author_facet | Nayeem Sadath Haneef S Ramachandra Arun Kumar Metta L Srujana |
| author_sort | Nayeem Sadath Haneef |
| collection | DOAJ |
| description | Linear IgA disease (LAD) is an acquired, autoimmune, subepidermal, blistering disease, characterized by linear deposition of IgA along the dermoepidermal junction on immunofluorescence. Some cases known as ′mixed immunobullous disease′ show weak staining with other immune reactants like IgG, IgM or C3. We report a rare case of a child having typical manifestations of LAD (chronic bullous disease of childhood), but with IgG predominance rather than IgA. Obviously it is improper to term this as linear IgA disease. Such cases are reported in literature as variants of LAD, with a multitude of terms like mixed immune bullous disease, linear IgG / IgA disease, linear IgA / IgG disease, and so on. In view of the tremendous confusion that these multiple terms cause in the absence of any practical benefit, we propose that the broad term ′chronic bullous disease of childhood′ be applied to all childhood cases, irrespective of the nature of the immune deposits. |
| first_indexed | 2024-12-14T23:27:10Z |
| format | Article |
| id | doaj.art-d565854e3ad14839873da93840d10aee |
| institution | Directory Open Access Journal |
| issn | 0019-5154 1998-3611 |
| language | English |
| last_indexed | 2024-12-14T23:27:10Z |
| publishDate | 2012-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Dermatology |
| spelling | doaj.art-d565854e3ad14839873da93840d10aee2022-12-21T22:43:47ZengWolters Kluwer Medknow PublicationsIndian Journal of Dermatology0019-51541998-36112012-01-0157428528710.4103/0019-5154.97670Chronic bullous disease of childhood with IgG predominance: What is the locus standi?Nayeem Sadath HaneefS RamachandraArun Kumar MettaL SrujanaLinear IgA disease (LAD) is an acquired, autoimmune, subepidermal, blistering disease, characterized by linear deposition of IgA along the dermoepidermal junction on immunofluorescence. Some cases known as ′mixed immunobullous disease′ show weak staining with other immune reactants like IgG, IgM or C3. We report a rare case of a child having typical manifestations of LAD (chronic bullous disease of childhood), but with IgG predominance rather than IgA. Obviously it is improper to term this as linear IgA disease. Such cases are reported in literature as variants of LAD, with a multitude of terms like mixed immune bullous disease, linear IgG / IgA disease, linear IgA / IgG disease, and so on. In view of the tremendous confusion that these multiple terms cause in the absence of any practical benefit, we propose that the broad term ′chronic bullous disease of childhood′ be applied to all childhood cases, irrespective of the nature of the immune deposits.http://www.e-ijd.org/article.asp?issn=0019-5154;year=2012;volume=57;issue=4;spage=285;epage=287;aulast=HaneefChronic bullous disease of childhoodlinear IgA diseaselinear IgG / IgA diseasemixed immunobullous disease |
| spellingShingle | Nayeem Sadath Haneef S Ramachandra Arun Kumar Metta L Srujana Chronic bullous disease of childhood with IgG predominance: What is the locus standi? Indian Journal of Dermatology Chronic bullous disease of childhood linear IgA disease linear IgG / IgA disease mixed immunobullous disease |
| title | Chronic bullous disease of childhood with IgG predominance: What is the locus standi? |
| title_full | Chronic bullous disease of childhood with IgG predominance: What is the locus standi? |
| title_fullStr | Chronic bullous disease of childhood with IgG predominance: What is the locus standi? |
| title_full_unstemmed | Chronic bullous disease of childhood with IgG predominance: What is the locus standi? |
| title_short | Chronic bullous disease of childhood with IgG predominance: What is the locus standi? |
| title_sort | chronic bullous disease of childhood with igg predominance what is the locus standi |
| topic | Chronic bullous disease of childhood linear IgA disease linear IgG / IgA disease mixed immunobullous disease |
| url | http://www.e-ijd.org/article.asp?issn=0019-5154;year=2012;volume=57;issue=4;spage=285;epage=287;aulast=Haneef |
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