Synthesis of DPIE [2-(1,2-Diphenyl-1<i>H</i>-indol-3-yl)ethanamine] Derivatives and Their Regulatory Effects on Pro-Inflammatory Cytokine Production in IL-1β-Stimulated Primary Human Oral Cells

Synthesis of DPIE [2-(1,2-Diphenyl-1<i>H</i>-indol-3-yl)ethanamine] Derivatives and Their Regulatory Effects on Pro-Inflammatory Cytokine Production in IL-1β-Stimulated Primary Human Oral Cells

Interleukin-1 beta (IL-1β) has diverse physiological functions and plays important roles in health and disease. In this report, we focus on its function in the production of pro-inflammatory cytokines, including IL-6 and IL-8, which are implicated in several autoimmune diseases and host defense agai...

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Bibliographic Details
Main Authors: Jeongah Lim, Jihyoun Seong, Seunggon Jung, Tae-Hoon Lee, Eunae Kim, Sunwoo Lee
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Molecules
Subjects:
IL-1
IL-1R1
pro-inflammatory cytokine
DPIE derivative
Online Access:https://www.mdpi.com/1420-3049/27/3/899

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