T Cells Actively Infiltrate the White Matter of the Aging Monkey Brain in Relation to Increased Microglial Reactivity and Cognitive Decline

T Cells Actively Infiltrate the White Matter of the Aging Monkey Brain in Relation to Increased Microglial Reactivity and Cognitive Decline

Normal aging is characterized by declines in processing speed, learning, memory, and executive function even in the absence of neurodegenerative diseases such as Alzheimer's Disease (AD). In normal aging monkeys and humans, neuronal loss does not account for cognitive impairment. Instead, loss...

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Bibliographic Details
Main Authors: Katelyn V. Batterman, Payton E. Cabrera, Tara L. Moore, Douglas L. Rosene
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
myelin
T cells
aging
cognitive decline
microglia
blood brain barrier
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.607691/full

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