Comparative analysis of clinical-scale IFN-gamma positive T-cell enrichment using partially and fully integrated platforms

Comparative analysis of clinical-scale IFN-gamma positive T-cell enrichment using partially and fully integrated platforms

Background and aims. The infusion of enriched CMV-specific donor T-cells appears to be a suitable alternative for the treatment of drug resistant CMV reactivation or de novo infection after both solid organ and hematopoietic stem cell transplantation. Antiviral lymphocytes can be selected from apher...

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Bibliographic Details
Main Authors: Christoph Priesner, Ruth Esser, Sabine Tischer, Michael Marburger, Krasimira Aleksandrova, Britta Maecker-Kolhoff, Hans-Gert Heuft, Lilia Goudeva, Rainer Blasczyk, Lubomir Arseniev, Ulrike Koehl, Britta Eiz-Vesper, Stephan Kloess
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-09-01
Series:Frontiers in Immunology
Subjects:
Closed GMP-compliant systems
immuneaffinity cell selection
Virus-specific T-cells
single platform and multicolor flow cytometry.
CliniMACS Cytokine-Capture-System
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00393/full

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