Yeast quiescence exit swiftness is influenced by cell volume and chronological age
Quiescence exit swiftness is crucial not only for micro-organisms in competition for an environmental niche, such as yeast, but also for the maintenance of tissue homeostasis in multicellular species. Here we explore the effect of replicative and chronological age on Saccharomyces cerevisiae quiesce...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Shared Science Publishers OG
2017-12-01
|
| Series: | Microbial Cell |
| Subjects: | |
| Online Access: | http://microbialcell.com/researcharticles/yeast-quiescence-exit-swiftness-is-influenced-by-cell-volume-and-chronological-age/ |
| _version_ | 1826532001926086656 |
|---|---|
| author | Damien Laporte Laure Jimenez Laëtitia Gouleme Isabelle Sagot |
| author_facet | Damien Laporte Laure Jimenez Laëtitia Gouleme Isabelle Sagot |
| author_sort | Damien Laporte |
| collection | DOAJ |
| description | Quiescence exit swiftness is crucial not only for micro-organisms in competition for an environmental niche, such as yeast, but also for the maintenance of tissue homeostasis in multicellular species. Here we explore the effect of replicative and chronological age on Saccharomyces cerevisiae quiescence exit efficiency. Our study reveals that this step strongly relies on the cell volume in quiescence but is not influenced by cell replicative age, at least for cells that have undergone less than 10 divisions. Furthermore, we establish that chronological age strongly impinges on cell’s capacities to exit quiescence. This effect is not related to cell volume or due to cell’s inability to metabolize external glucose but rather seems to depend on intracellular trehalose concentration. Overall, our data illustrate that the quiescent state is a continuum evolving with time, early and deep quiescence being distinguishable by the cell’s proficiency to re-enter the proliferation cycle. |
| first_indexed | 2024-12-14T00:10:50Z |
| format | Article |
| id | doaj.art-d568fcb0ecfb445082346b66430b64b7 |
| institution | Directory Open Access Journal |
| issn | 2311-2638 |
| language | English |
| last_indexed | 2025-03-14T01:44:18Z |
| publishDate | 2017-12-01 |
| publisher | Shared Science Publishers OG |
| record_format | Article |
| series | Microbial Cell |
| spelling | doaj.art-d568fcb0ecfb445082346b66430b64b72025-03-12T13:46:44ZengShared Science Publishers OGMicrobial Cell2311-26382017-12-015210411110.15698/mic2018.02.615Yeast quiescence exit swiftness is influenced by cell volume and chronological ageDamien Laporte0Laure Jimenez1Laëtitia Gouleme2Isabelle Sagot3CNRS, Université de Bordeaux – Institut de Biochimie et Génétique Cellulaires, UMR5095 – 33077 Bordeaux cedex, France.CNRS, Université de Bordeaux – Institut de Biochimie et Génétique Cellulaires, UMR5095 – 33077 Bordeaux cedex, France.CNRS, Université de Bordeaux – Institut de Biochimie et Génétique Cellulaires, UMR5095 – 33077 Bordeaux cedex, France.CNRS, Université de Bordeaux – Institut de Biochimie et Génétique Cellulaires, UMR5095 – 33077 Bordeaux cedex, France.Quiescence exit swiftness is crucial not only for micro-organisms in competition for an environmental niche, such as yeast, but also for the maintenance of tissue homeostasis in multicellular species. Here we explore the effect of replicative and chronological age on Saccharomyces cerevisiae quiescence exit efficiency. Our study reveals that this step strongly relies on the cell volume in quiescence but is not influenced by cell replicative age, at least for cells that have undergone less than 10 divisions. Furthermore, we establish that chronological age strongly impinges on cell’s capacities to exit quiescence. This effect is not related to cell volume or due to cell’s inability to metabolize external glucose but rather seems to depend on intracellular trehalose concentration. Overall, our data illustrate that the quiescent state is a continuum evolving with time, early and deep quiescence being distinguishable by the cell’s proficiency to re-enter the proliferation cycle.http://microbialcell.com/researcharticles/yeast-quiescence-exit-swiftness-is-influenced-by-cell-volume-and-chronological-age/S. cerevisiaequiescenceagingcell size |
| spellingShingle | Damien Laporte Laure Jimenez Laëtitia Gouleme Isabelle Sagot Yeast quiescence exit swiftness is influenced by cell volume and chronological age Microbial Cell S. cerevisiae quiescence aging cell size |
| title | Yeast quiescence exit swiftness is influenced by cell volume and chronological age |
| title_full | Yeast quiescence exit swiftness is influenced by cell volume and chronological age |
| title_fullStr | Yeast quiescence exit swiftness is influenced by cell volume and chronological age |
| title_full_unstemmed | Yeast quiescence exit swiftness is influenced by cell volume and chronological age |
| title_short | Yeast quiescence exit swiftness is influenced by cell volume and chronological age |
| title_sort | yeast quiescence exit swiftness is influenced by cell volume and chronological age |
| topic | S. cerevisiae quiescence aging cell size |
| url | http://microbialcell.com/researcharticles/yeast-quiescence-exit-swiftness-is-influenced-by-cell-volume-and-chronological-age/ |
| work_keys_str_mv | AT damienlaporte yeastquiescenceexitswiftnessisinfluencedbycellvolumeandchronologicalage AT laurejimenez yeastquiescenceexitswiftnessisinfluencedbycellvolumeandchronologicalage AT laetitiagouleme yeastquiescenceexitswiftnessisinfluencedbycellvolumeandchronologicalage AT isabellesagot yeastquiescenceexitswiftnessisinfluencedbycellvolumeandchronologicalage |