Dual inhibition of EGFR and IL-6-STAT3 signalling by miR-146b: a potential targeted therapy for epithelial ovarian cancer

Dual inhibition of EGFR and IL-6-STAT3 signalling by miR-146b: a potential targeted therapy for epithelial ovarian cancer

Epidermal growth factor receptor (EGFR) signalling and the interleukin-6 (IL-6)/signal transducer and activator of transcription 3 (STAT3) are aberrantly activated in ovarian cancer. However, inhibition of EGFR signalling in ovarian cancer patients resulted in a disappointing clinical benefit. In th...

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Bibliographic Details
Main Authors: Meina Yan, Mutian Han, Xinxin Yang, Rong Shen, Hui Wang, Lubin Zhang, Sheng Xia, Peifang Yang, Guanghua Zhai, Qixiang Shao
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
mir-146b
egfr
stat3
epithelial ovarian cancer
Online Access:http://dx.doi.org/10.1080/14756366.2021.1963240

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