A case report on the association between QTc prolongation and remdesivir therapy in a critically ill patient
Remdesivir is a direct-acting inhibitor of SARS-CoV-2 RNA-dependent RNA polymerase that is used to treat severe COVID-19 infections. We report a patient with severe COVID-19 pneumonia who experienced palpitations and syncope two days after starting remdesivir therapy. The QTc interval was prolonged...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | IDCases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214250922002001 |
| _version_ | 1817995076805066752 |
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| author | Shmeylan Al Harbi Mashael AlFaifi Hasan M. Al-Dorzi Ohoud Aljuhani Abeer A. Alenazi Mai Alalawi Khalid Al Sulaiman |
| author_facet | Shmeylan Al Harbi Mashael AlFaifi Hasan M. Al-Dorzi Ohoud Aljuhani Abeer A. Alenazi Mai Alalawi Khalid Al Sulaiman |
| author_sort | Shmeylan Al Harbi |
| collection | DOAJ |
| description | Remdesivir is a direct-acting inhibitor of SARS-CoV-2 RNA-dependent RNA polymerase that is used to treat severe COVID-19 infections. We report a patient with severe COVID-19 pneumonia who experienced palpitations and syncope two days after starting remdesivir therapy. The QTc interval was prolonged on the Electrocardiogram (ECG) without any significant electrolyte abnormalities or concomitant use of medications with QTc prolongation. Although the cardiac side effects of remdesivir therapy have been well documented, the link between remdesivir therapy and QTc interval prolongation in patients with severe COVID-19 has only been observed in a few cases. Because this arrhythmia has the potential to result in sudden cardiac death, practitioners should be aware of the QTc interval prolongation associated with remdesivir therapy. |
| first_indexed | 2024-04-14T02:00:37Z |
| format | Article |
| id | doaj.art-d56b9b72ab1c4e5c8ee64757bea5c545 |
| institution | Directory Open Access Journal |
| issn | 2214-2509 |
| language | English |
| last_indexed | 2024-04-14T02:00:37Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | IDCases |
| spelling | doaj.art-d56b9b72ab1c4e5c8ee64757bea5c5452022-12-22T02:18:51ZengElsevierIDCases2214-25092022-01-0129e01572A case report on the association between QTc prolongation and remdesivir therapy in a critically ill patientShmeylan Al Harbi0Mashael AlFaifi1Hasan M. Al-Dorzi2Ohoud Aljuhani3Abeer A. Alenazi4Mai Alalawi5Khalid Al Sulaiman6College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia; King Abdullah International Medical Research Center-King Saud Bin Abdulaziz University for Health Sciences, Ministry of National Guard – Health Affairs, Riyadh, Saudi Arabia; Pharmaceutical Care Department, King Abdulaziz Medical City, Riyadh, Saudi ArabiaCollege of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia; Pharmaceutical Services Administration, King Saud Medical City, Riyadh. Saudi ArabiaKing Abdullah International Medical Research Center-King Saud Bin Abdulaziz University for Health Sciences, Ministry of National Guard – Health Affairs, Riyadh, Saudi Arabia; College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia; Intensive Care Department, Ministry of National Guard – Health Affairs, Riyadh, Saudi ArabiaDepartment of Pharmacy Practice, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi ArabiaPharmaceutical Care Department, Prince Sultan Military Medical City, Riyadh, Saudi ArabiaDepartment of Pharmaceutical Sciences, Fakeeh College for Medical Sciences, Jeddah, Saudi ArabiaCollege of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia; King Abdullah International Medical Research Center-King Saud Bin Abdulaziz University for Health Sciences, Ministry of National Guard – Health Affairs, Riyadh, Saudi Arabia; Pharmaceutical Care Department, King Abdulaziz Medical City, Riyadh, Saudi Arabia; Saudi Critical Care Pharmacy Research (SCAPE) Platform, Riyadh, Saudi Arabia; Corresponding author at: King Abdulaziz Medical City (KAMC) - Ministry of National Guard Health Affairs (MNGHA), King Abdullah International Medical Research Center/King Saud bin Abdulaziz University for Health Sciences, PO Box 22490, 11426 Riyadh, Saudi Arabia.Remdesivir is a direct-acting inhibitor of SARS-CoV-2 RNA-dependent RNA polymerase that is used to treat severe COVID-19 infections. We report a patient with severe COVID-19 pneumonia who experienced palpitations and syncope two days after starting remdesivir therapy. The QTc interval was prolonged on the Electrocardiogram (ECG) without any significant electrolyte abnormalities or concomitant use of medications with QTc prolongation. Although the cardiac side effects of remdesivir therapy have been well documented, the link between remdesivir therapy and QTc interval prolongation in patients with severe COVID-19 has only been observed in a few cases. Because this arrhythmia has the potential to result in sudden cardiac death, practitioners should be aware of the QTc interval prolongation associated with remdesivir therapy.http://www.sciencedirect.com/science/article/pii/S2214250922002001RemdesivirQTc prolongationCoronavirus disease 2019 (Covid-19) |
| spellingShingle | Shmeylan Al Harbi Mashael AlFaifi Hasan M. Al-Dorzi Ohoud Aljuhani Abeer A. Alenazi Mai Alalawi Khalid Al Sulaiman A case report on the association between QTc prolongation and remdesivir therapy in a critically ill patient IDCases Remdesivir QTc prolongation Coronavirus disease 2019 (Covid-19) |
| title | A case report on the association between QTc prolongation and remdesivir therapy in a critically ill patient |
| title_full | A case report on the association between QTc prolongation and remdesivir therapy in a critically ill patient |
| title_fullStr | A case report on the association between QTc prolongation and remdesivir therapy in a critically ill patient |
| title_full_unstemmed | A case report on the association between QTc prolongation and remdesivir therapy in a critically ill patient |
| title_short | A case report on the association between QTc prolongation and remdesivir therapy in a critically ill patient |
| title_sort | case report on the association between qtc prolongation and remdesivir therapy in a critically ill patient |
| topic | Remdesivir QTc prolongation Coronavirus disease 2019 (Covid-19) |
| url | http://www.sciencedirect.com/science/article/pii/S2214250922002001 |
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