Features of the apoptosis markers expression by skin cell with ageing

The immunohistochemical study of skin was conducted to verify presence of p53, bcl-2 and bax apoptosis markers in epidermal keratinocytes of patients from two age groups: 16 to 44 years old and 45 to 64 years old. It was discovered that with chronological ageing of skin the expression levels of p53...

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Main Authors: T. Yu. Vitruk, N. V. Ryazantseva, P. N. Pesterev, L. R. Mustafina
Format: Article
Language:English
Published: Siberian State Medical University (Tomsk) 2008-06-01
Series:Бюллетень сибирской медицины
Subjects:
Online Access:https://bulletin.ssmu.ru/jour/article/view/3372
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author T. Yu. Vitruk
N. V. Ryazantseva
P. N. Pesterev
L. R. Mustafina
author_facet T. Yu. Vitruk
N. V. Ryazantseva
P. N. Pesterev
L. R. Mustafina
author_sort T. Yu. Vitruk
collection DOAJ
description The immunohistochemical study of skin was conducted to verify presence of p53, bcl-2 and bax apoptosis markers in epidermal keratinocytes of patients from two age groups: 16 to 44 years old and 45 to 64 years old. It was discovered that with chronological ageing of skin the expression levels of p53 and bax apoptosis markers are raised by epidermal cells in patients of elder age group. Obtained data testifies to cumulative damaging effect of a quantity of proapoptotic factors (oxidative stress, UV-waves, ionizing radiation, chemical reagents etc.) on epidermal cells with ageing.
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spelling doaj.art-d56be0bf664c48f09c3b630aa73634a62023-03-13T09:58:08ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842008-06-0172232810.20538/1682-0363-2008-2-23-282028Features of the apoptosis markers expression by skin cell with ageingT. Yu. Vitruk0N. V. Ryazantseva1P. N. Pesterev2L. R. Mustafina3Сибирский государственный медицинский университетСибирский государственный медицинский университетСибирский государственный медицинский университетСибирский государственный медицинский университетThe immunohistochemical study of skin was conducted to verify presence of p53, bcl-2 and bax apoptosis markers in epidermal keratinocytes of patients from two age groups: 16 to 44 years old and 45 to 64 years old. It was discovered that with chronological ageing of skin the expression levels of p53 and bax apoptosis markers are raised by epidermal cells in patients of elder age group. Obtained data testifies to cumulative damaging effect of a quantity of proapoptotic factors (oxidative stress, UV-waves, ionizing radiation, chemical reagents etc.) on epidermal cells with ageing.https://bulletin.ssmu.ru/jour/article/view/3372старение кожиапоптозкератиноцитыskin ageingapoptosiskeratinocytes
spellingShingle T. Yu. Vitruk
N. V. Ryazantseva
P. N. Pesterev
L. R. Mustafina
Features of the apoptosis markers expression by skin cell with ageing
Бюллетень сибирской медицины
старение кожи
апоптоз
кератиноциты
skin ageing
apoptosis
keratinocytes
title Features of the apoptosis markers expression by skin cell with ageing
title_full Features of the apoptosis markers expression by skin cell with ageing
title_fullStr Features of the apoptosis markers expression by skin cell with ageing
title_full_unstemmed Features of the apoptosis markers expression by skin cell with ageing
title_short Features of the apoptosis markers expression by skin cell with ageing
title_sort features of the apoptosis markers expression by skin cell with ageing
topic старение кожи
апоптоз
кератиноциты
skin ageing
apoptosis
keratinocytes
url https://bulletin.ssmu.ru/jour/article/view/3372
work_keys_str_mv AT tyuvitruk featuresoftheapoptosismarkersexpressionbyskincellwithageing
AT nvryazantseva featuresoftheapoptosismarkersexpressionbyskincellwithageing
AT pnpesterev featuresoftheapoptosismarkersexpressionbyskincellwithageing
AT lrmustafina featuresoftheapoptosismarkersexpressionbyskincellwithageing