Favorable effect of corticosteroids in treating acute-on-chronic liver failure underlying chronic hepatitis B
Acute-on-chronic liver failure (ACLF) occurs in the presence of a chronic liver disease or cirrhosis, and often results from exacerbation of chronic hepatitis B (CHB). The efficacy of corticosteroid treatment in ACLF patients with underlying CHB remains unclear. We report the case of a 50-year-old w...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Korean Association for the Study of the Liver
2018-12-01
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| Series: | Clinical and Molecular Hepatology |
| Subjects: | |
| Online Access: | http://e-cmh.org/upload/pdf/cmh-2017-0016.pdf |
| _version_ | 1811210537467379712 |
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| author | Hyeji Kim Jung Hyun Kwon Yong Hee Kim Soon Woo Nam Jong Yul Lee Jeong Won Jang |
| author_facet | Hyeji Kim Jung Hyun Kwon Yong Hee Kim Soon Woo Nam Jong Yul Lee Jeong Won Jang |
| author_sort | Hyeji Kim |
| collection | DOAJ |
| description | Acute-on-chronic liver failure (ACLF) occurs in the presence of a chronic liver disease or cirrhosis, and often results from exacerbation of chronic hepatitis B (CHB). The efficacy of corticosteroid treatment in ACLF patients with underlying CHB remains unclear. We report the case of a 50-year-old woman who experienced ACLF due to CHB exacerbation and was treated with a combination of corticosteroids and nucleot(s)ide analogue (NUC). The patient showed rapid decompensation due to CHB exacerbation. Three months of antiviral therapy produced no improvement in liver function. Combination therapy with corticosteroids and NUC was started, which did result in improvement of liver function. This case shows that the combined therapy of corticosteroids and NUC can be effective in treating ACLF due to CHB exacerbation. |
| first_indexed | 2024-04-12T04:57:16Z |
| format | Article |
| id | doaj.art-d56cf86ce07e4595a6428c1c795e987b |
| institution | Directory Open Access Journal |
| issn | 2287-2728 2287-285X |
| language | English |
| last_indexed | 2024-04-12T04:57:16Z |
| publishDate | 2018-12-01 |
| publisher | Korean Association for the Study of the Liver |
| record_format | Article |
| series | Clinical and Molecular Hepatology |
| spelling | doaj.art-d56cf86ce07e4595a6428c1c795e987b2022-12-22T03:47:06ZengKorean Association for the Study of the LiverClinical and Molecular Hepatology2287-27282287-285X2018-12-0124443043510.3350/cmh.2017.00161390Favorable effect of corticosteroids in treating acute-on-chronic liver failure underlying chronic hepatitis BHyeji Kim0Jung Hyun Kwon1Yong Hee Kim2Soon Woo Nam3Jong Yul Lee4Jeong Won Jang5 Department of Internal Medicine, The Catholic University of Korea Incheon St. Mary’s Hospital, Incheon, Korea Department of Internal Medicine, The Catholic University of Korea Incheon St. Mary’s Hospital, Incheon, Korea Department of Internal Medicine, The Catholic University of Korea Incheon St. Mary’s Hospital, Incheon, Korea Department of Internal Medicine, The Catholic University of Korea Incheon St. Mary’s Hospital, Incheon, Korea Department of Internal Medicine, The Catholic University of Korea Incheon St. Mary’s Hospital, Incheon, Korea Department of Internal Medicine, The Catholic University of Korea Seoul St. Mary’s Hospital, Seoul, KoreaAcute-on-chronic liver failure (ACLF) occurs in the presence of a chronic liver disease or cirrhosis, and often results from exacerbation of chronic hepatitis B (CHB). The efficacy of corticosteroid treatment in ACLF patients with underlying CHB remains unclear. We report the case of a 50-year-old woman who experienced ACLF due to CHB exacerbation and was treated with a combination of corticosteroids and nucleot(s)ide analogue (NUC). The patient showed rapid decompensation due to CHB exacerbation. Three months of antiviral therapy produced no improvement in liver function. Combination therapy with corticosteroids and NUC was started, which did result in improvement of liver function. This case shows that the combined therapy of corticosteroids and NUC can be effective in treating ACLF due to CHB exacerbation.http://e-cmh.org/upload/pdf/cmh-2017-0016.pdfacute-on-chronic liver failurechronic hepatitis bcorticosteroidexacerbationreactivation |
| spellingShingle | Hyeji Kim Jung Hyun Kwon Yong Hee Kim Soon Woo Nam Jong Yul Lee Jeong Won Jang Favorable effect of corticosteroids in treating acute-on-chronic liver failure underlying chronic hepatitis B Clinical and Molecular Hepatology acute-on-chronic liver failure chronic hepatitis b corticosteroid exacerbation reactivation |
| title | Favorable effect of corticosteroids in treating acute-on-chronic liver failure underlying chronic hepatitis B |
| title_full | Favorable effect of corticosteroids in treating acute-on-chronic liver failure underlying chronic hepatitis B |
| title_fullStr | Favorable effect of corticosteroids in treating acute-on-chronic liver failure underlying chronic hepatitis B |
| title_full_unstemmed | Favorable effect of corticosteroids in treating acute-on-chronic liver failure underlying chronic hepatitis B |
| title_short | Favorable effect of corticosteroids in treating acute-on-chronic liver failure underlying chronic hepatitis B |
| title_sort | favorable effect of corticosteroids in treating acute on chronic liver failure underlying chronic hepatitis b |
| topic | acute-on-chronic liver failure chronic hepatitis b corticosteroid exacerbation reactivation |
| url | http://e-cmh.org/upload/pdf/cmh-2017-0016.pdf |
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