Research progress of DNA damage repair and its effect on perioperative cognitive dysfunction
The dynamic balance between DNA double-strand break (DSB) accumulation and repair is one of the important factors to maintain genomic stability. The homologous recombination (HR) and the non-homologous ending joining (NHEJ) are the two major pathways to repair DSB.In mature neurons of the central ne...
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| Format: | Article |
| Language: | zho |
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Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
2022-04-01
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| Series: | Jichu yixue yu linchuang |
| Subjects: | |
| Online Access: | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2022-42-4-675.pdf |
| _version_ | 1827386956058722304 |
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| author | RONG Yu-lan, SHI Cheng-mei, GUO Xiang-yang |
| author_facet | RONG Yu-lan, SHI Cheng-mei, GUO Xiang-yang |
| author_sort | RONG Yu-lan, SHI Cheng-mei, GUO Xiang-yang |
| collection | DOAJ |
| description | The dynamic balance between DNA double-strand break (DSB) accumulation and repair is one of the important factors to maintain genomic stability. The homologous recombination (HR) and the non-homologous ending joining (NHEJ) are the two major pathways to repair DSB.In mature neurons of the central nervous system, the NHEJ is the main repair pathway of DSB.Recent studies in the molecular mechanism of NHEJ and peri-operative cognitive dysfunction (POCD) revealed several molecular mechanisms underlying the DNA damage repair and its links to POCD, which may provide a new therapeutic target. |
| first_indexed | 2024-03-08T15:54:02Z |
| format | Article |
| id | doaj.art-d56dd94572e849218d4d8468dcecd24c |
| institution | Directory Open Access Journal |
| issn | 1001-6325 |
| language | zho |
| last_indexed | 2024-03-08T15:54:02Z |
| publishDate | 2022-04-01 |
| publisher | Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. |
| record_format | Article |
| series | Jichu yixue yu linchuang |
| spelling | doaj.art-d56dd94572e849218d4d8468dcecd24c2024-01-09T02:51:38ZzhoInstitute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.Jichu yixue yu linchuang1001-63252022-04-0142467567810.16352/j.issn.1001-6325.2022.04.009Research progress of DNA damage repair and its effect on perioperative cognitive dysfunctionRONG Yu-lan, SHI Cheng-mei, GUO Xiang-yang0Department of Anesthesiology,Peking University Third Hospital,Beijing 100191,ChinaThe dynamic balance between DNA double-strand break (DSB) accumulation and repair is one of the important factors to maintain genomic stability. The homologous recombination (HR) and the non-homologous ending joining (NHEJ) are the two major pathways to repair DSB.In mature neurons of the central nervous system, the NHEJ is the main repair pathway of DSB.Recent studies in the molecular mechanism of NHEJ and peri-operative cognitive dysfunction (POCD) revealed several molecular mechanisms underlying the DNA damage repair and its links to POCD, which may provide a new therapeutic target.http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2022-42-4-675.pdfdna damage repair|non-homologous end joining|perioperative cognitive dysfunction |
| spellingShingle | RONG Yu-lan, SHI Cheng-mei, GUO Xiang-yang Research progress of DNA damage repair and its effect on perioperative cognitive dysfunction Jichu yixue yu linchuang dna damage repair|non-homologous end joining|perioperative cognitive dysfunction |
| title | Research progress of DNA damage repair and its effect on perioperative cognitive dysfunction |
| title_full | Research progress of DNA damage repair and its effect on perioperative cognitive dysfunction |
| title_fullStr | Research progress of DNA damage repair and its effect on perioperative cognitive dysfunction |
| title_full_unstemmed | Research progress of DNA damage repair and its effect on perioperative cognitive dysfunction |
| title_short | Research progress of DNA damage repair and its effect on perioperative cognitive dysfunction |
| title_sort | research progress of dna damage repair and its effect on perioperative cognitive dysfunction |
| topic | dna damage repair|non-homologous end joining|perioperative cognitive dysfunction |
| url | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2022-42-4-675.pdf |
| work_keys_str_mv | AT rongyulanshichengmeiguoxiangyang researchprogressofdnadamagerepairanditseffectonperioperativecognitivedysfunction |