Ultrasound-Induced Amino Acid-Based Hydrogels With Superior Mechanical Strength for Controllable Long-Term Release of Anti-Cercariae Drug
Stimulus-responsive hydrogels are significantly programmable materials that show potential applications in the field of biomedicine and the environment. Ultrasound as a stimulus can induce the formation of hydrogels, which exhibit the superior performance of different structures. In this study, we r...
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2021.703582/full |
| _version_ | 1819011355383955456 |
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| author | Liying Ling Liying Ling Lei Zhu Yibao Li Chunhua Liu Linxiu Cheng Linxiu Cheng |
| author_facet | Liying Ling Liying Ling Lei Zhu Yibao Li Chunhua Liu Linxiu Cheng Linxiu Cheng |
| author_sort | Liying Ling |
| collection | DOAJ |
| description | Stimulus-responsive hydrogels are significantly programmable materials that show potential applications in the field of biomedicine and the environment. Ultrasound as a stimulus can induce the formation of hydrogels, which exhibit the superior performance of different structures. In this study, we reported an ultrasound-induced supramolecular hydrogel based on aspartic acid derivative N,N′-diaspartate-3,4,9,10-perylene tetracarboxylic acid imide, showing superior performance in drug release. The results show that the driving force of this ultrasonic induced hydrogel could be attributed to hydrogen bonding and π-π interaction. The rheological and cytotoxicity test illustrate excellent mechanical properties and biocompatibility of the hydrogel. The anti-Schistosoma japonicum cercariae (CC) drug release results show large drug loadings (500 mg/ml) and long-term release (15 days) of this hydrogel. This study demonstrates that this hydrogel may serve as a slow-release platform for anti-CC. |
| first_indexed | 2024-12-21T01:26:50Z |
| format | Article |
| id | doaj.art-d56e17f1b9bc4299a9e9830ad30442f4 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-21T01:26:50Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-d56e17f1b9bc4299a9e9830ad30442f42022-12-21T19:20:30ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852021-10-01910.3389/fbioe.2021.703582703582Ultrasound-Induced Amino Acid-Based Hydrogels With Superior Mechanical Strength for Controllable Long-Term Release of Anti-Cercariae DrugLiying Ling0Liying Ling1Lei Zhu2Yibao Li3Chunhua Liu4Linxiu Cheng5Linxiu Cheng6Jiangxi Key Laboratory of Organo-Pharmaceutical Chemistry, Chemistry and Chemical Engineering College, Gannan Normal University, Ganzhou, ChinaResearch Center for Environmental Engineering and Technology, School of Geography and Environmental Engineering, Gannan Normal University, Ganzhou, ChinaJiangxi Key Laboratory of Organo-Pharmaceutical Chemistry, Chemistry and Chemical Engineering College, Gannan Normal University, Ganzhou, ChinaJiangxi Key Laboratory of Organo-Pharmaceutical Chemistry, Chemistry and Chemical Engineering College, Gannan Normal University, Ganzhou, ChinaJiangxi Key Laboratory of Organo-Pharmaceutical Chemistry, Chemistry and Chemical Engineering College, Gannan Normal University, Ganzhou, ChinaJiangxi Key Laboratory of Organo-Pharmaceutical Chemistry, Chemistry and Chemical Engineering College, Gannan Normal University, Ganzhou, ChinaResearch Center for Environmental Engineering and Technology, School of Geography and Environmental Engineering, Gannan Normal University, Ganzhou, ChinaStimulus-responsive hydrogels are significantly programmable materials that show potential applications in the field of biomedicine and the environment. Ultrasound as a stimulus can induce the formation of hydrogels, which exhibit the superior performance of different structures. In this study, we reported an ultrasound-induced supramolecular hydrogel based on aspartic acid derivative N,N′-diaspartate-3,4,9,10-perylene tetracarboxylic acid imide, showing superior performance in drug release. The results show that the driving force of this ultrasonic induced hydrogel could be attributed to hydrogen bonding and π-π interaction. The rheological and cytotoxicity test illustrate excellent mechanical properties and biocompatibility of the hydrogel. The anti-Schistosoma japonicum cercariae (CC) drug release results show large drug loadings (500 mg/ml) and long-term release (15 days) of this hydrogel. This study demonstrates that this hydrogel may serve as a slow-release platform for anti-CC.https://www.frontiersin.org/articles/10.3389/fbioe.2021.703582/fullultrasound-inducedamino acid-basedhydrogelslong-term releaseanti-cercariae |
| spellingShingle | Liying Ling Liying Ling Lei Zhu Yibao Li Chunhua Liu Linxiu Cheng Linxiu Cheng Ultrasound-Induced Amino Acid-Based Hydrogels With Superior Mechanical Strength for Controllable Long-Term Release of Anti-Cercariae Drug Frontiers in Bioengineering and Biotechnology ultrasound-induced amino acid-based hydrogels long-term release anti-cercariae |
| title | Ultrasound-Induced Amino Acid-Based Hydrogels With Superior Mechanical Strength for Controllable Long-Term Release of Anti-Cercariae Drug |
| title_full | Ultrasound-Induced Amino Acid-Based Hydrogels With Superior Mechanical Strength for Controllable Long-Term Release of Anti-Cercariae Drug |
| title_fullStr | Ultrasound-Induced Amino Acid-Based Hydrogels With Superior Mechanical Strength for Controllable Long-Term Release of Anti-Cercariae Drug |
| title_full_unstemmed | Ultrasound-Induced Amino Acid-Based Hydrogels With Superior Mechanical Strength for Controllable Long-Term Release of Anti-Cercariae Drug |
| title_short | Ultrasound-Induced Amino Acid-Based Hydrogels With Superior Mechanical Strength for Controllable Long-Term Release of Anti-Cercariae Drug |
| title_sort | ultrasound induced amino acid based hydrogels with superior mechanical strength for controllable long term release of anti cercariae drug |
| topic | ultrasound-induced amino acid-based hydrogels long-term release anti-cercariae |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2021.703582/full |
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