Pericoronary adipose tissue attenuation on coronary computed tomography angiography associates with male sex and Indigenous Australian status
Abstract To evaluate if Indigenous Australians have higher coronary inflammation demonstrated non-invasively using pericoronary adipose tissue attenuation on coronary computed tomography angiography (CCTA). We retrospectively obtained a cohort 54 Indigenous patients age- and sex-matched to 54 non-In...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-09-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-41341-9 |
| _version_ | 1797576728609030144 |
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| author | Jeremy Yuvaraj Egynne Lim Tony Vo David Huynh Cheniqua Rocco Nitesh Nerlekar Kevin Cheng Andrew Lin Damini Dey Stephen J. Nicholls Nadarajah Kangaharan Dennis T.L. Wong |
| author_facet | Jeremy Yuvaraj Egynne Lim Tony Vo David Huynh Cheniqua Rocco Nitesh Nerlekar Kevin Cheng Andrew Lin Damini Dey Stephen J. Nicholls Nadarajah Kangaharan Dennis T.L. Wong |
| author_sort | Jeremy Yuvaraj |
| collection | DOAJ |
| description | Abstract To evaluate if Indigenous Australians have higher coronary inflammation demonstrated non-invasively using pericoronary adipose tissue attenuation on coronary computed tomography angiography (CCTA). We retrospectively obtained a cohort 54 Indigenous patients age- and sex-matched to 54 non-Indigenous controls (age: 46.5 ± 13.1 years; male: n = 66) undergoing CCTA at the Royal Darwin Hospital and Monash Medical Centre. Patient groups were defined to investigate the interaction of ethnicity and sex: Indigenous + male, Indigenous + female, control + male, control + female. Semi-automated software was used to assess pericoronary adipose tissue attenuation (PCAT-a) and volume (PCAT-v). Males had significantly higher PCAT-a (– 86.7 ± 7.8 HU vs. − 91.3 ± 7.1 HU, p = 0.003) than females. Indigenous patients had significantly higher PCAT-v (1.5 ± 0.5cm3 vs. 1.3 ± 0.4cm3, p = 0.032), but only numerically higher PCAT-a (p = 0.133) than controls. There was a significant difference in PCAT-a and PCAT-v across groups defined by Indigenous status and sex (p = 0.010 and p = 0.030, respectively). Among patients with matching CCTA contrast density, multivariable linear regression analysis showed an independent association between Indigenous status and PCAT-a. Indigenous men have increased PCAT-a in an age- and sex-matched cohort. Male sex is strongly associated with increased PCAT-a. Coronary inflammation may contribute to adverse cardiovascular outcomes in Indigenous Australians, but larger studies are required to validate these findings. |
| first_indexed | 2024-03-10T21:57:51Z |
| format | Article |
| id | doaj.art-d56e6f2d929d4f1580055f7d1a911a09 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-10T21:57:51Z |
| publishDate | 2023-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-d56e6f2d929d4f1580055f7d1a911a092023-11-19T13:04:12ZengNature PortfolioScientific Reports2045-23222023-09-0113111110.1038/s41598-023-41341-9Pericoronary adipose tissue attenuation on coronary computed tomography angiography associates with male sex and Indigenous Australian statusJeremy Yuvaraj0Egynne Lim1Tony Vo2David Huynh3Cheniqua Rocco4Nitesh Nerlekar5Kevin Cheng6Andrew Lin7Damini Dey8Stephen J. Nicholls9Nadarajah Kangaharan10Dennis T.L. Wong11Monash Cardiovascular Research Centre, Victorian Heart Institute, MonashHeart and Monash University, Monash HealthMonash Cardiovascular Research Centre, Victorian Heart Institute, MonashHeart and Monash University, Monash HealthDivision of Medicine, Royal Darwin HospitalDivision of Medicine, Royal Darwin HospitalDivision of Medicine, Royal Darwin HospitalMonash Cardiovascular Research Centre, Victorian Heart Institute, MonashHeart and Monash University, Monash HealthMonash Cardiovascular Research Centre, Victorian Heart Institute, MonashHeart and Monash University, Monash HealthCedars-Sinai Medical Center, Biomedical Imaging Research InstituteCedars-Sinai Medical Center, Biomedical Imaging Research InstituteMonash Cardiovascular Research Centre, Victorian Heart Institute, MonashHeart and Monash University, Monash HealthDivision of Medicine, Royal Darwin HospitalMonash Cardiovascular Research Centre, Victorian Heart Institute, MonashHeart and Monash University, Monash HealthAbstract To evaluate if Indigenous Australians have higher coronary inflammation demonstrated non-invasively using pericoronary adipose tissue attenuation on coronary computed tomography angiography (CCTA). We retrospectively obtained a cohort 54 Indigenous patients age- and sex-matched to 54 non-Indigenous controls (age: 46.5 ± 13.1 years; male: n = 66) undergoing CCTA at the Royal Darwin Hospital and Monash Medical Centre. Patient groups were defined to investigate the interaction of ethnicity and sex: Indigenous + male, Indigenous + female, control + male, control + female. Semi-automated software was used to assess pericoronary adipose tissue attenuation (PCAT-a) and volume (PCAT-v). Males had significantly higher PCAT-a (– 86.7 ± 7.8 HU vs. − 91.3 ± 7.1 HU, p = 0.003) than females. Indigenous patients had significantly higher PCAT-v (1.5 ± 0.5cm3 vs. 1.3 ± 0.4cm3, p = 0.032), but only numerically higher PCAT-a (p = 0.133) than controls. There was a significant difference in PCAT-a and PCAT-v across groups defined by Indigenous status and sex (p = 0.010 and p = 0.030, respectively). Among patients with matching CCTA contrast density, multivariable linear regression analysis showed an independent association between Indigenous status and PCAT-a. Indigenous men have increased PCAT-a in an age- and sex-matched cohort. Male sex is strongly associated with increased PCAT-a. Coronary inflammation may contribute to adverse cardiovascular outcomes in Indigenous Australians, but larger studies are required to validate these findings.https://doi.org/10.1038/s41598-023-41341-9 |
| spellingShingle | Jeremy Yuvaraj Egynne Lim Tony Vo David Huynh Cheniqua Rocco Nitesh Nerlekar Kevin Cheng Andrew Lin Damini Dey Stephen J. Nicholls Nadarajah Kangaharan Dennis T.L. Wong Pericoronary adipose tissue attenuation on coronary computed tomography angiography associates with male sex and Indigenous Australian status Scientific Reports |
| title | Pericoronary adipose tissue attenuation on coronary computed tomography angiography associates with male sex and Indigenous Australian status |
| title_full | Pericoronary adipose tissue attenuation on coronary computed tomography angiography associates with male sex and Indigenous Australian status |
| title_fullStr | Pericoronary adipose tissue attenuation on coronary computed tomography angiography associates with male sex and Indigenous Australian status |
| title_full_unstemmed | Pericoronary adipose tissue attenuation on coronary computed tomography angiography associates with male sex and Indigenous Australian status |
| title_short | Pericoronary adipose tissue attenuation on coronary computed tomography angiography associates with male sex and Indigenous Australian status |
| title_sort | pericoronary adipose tissue attenuation on coronary computed tomography angiography associates with male sex and indigenous australian status |
| url | https://doi.org/10.1038/s41598-023-41341-9 |
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