MFG-E8 promotes osteogenic transdifferentiation of smooth muscle cells and vascular calcification by regulating TGF-β1 signaling
A molecular link between the milk fat globule–epidermal growth factor 8 (MFG-E8), activation of vascular calcification driver TGF-β1 and osteogenic differentiation of vascular smooth muscle cells suggests that MFG-E8 could be a therapeutic target for vascular calcification.
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-04-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-022-03313-z |
| _version_ | 1818127846124552192 |
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| author | Hou-Yu Chiang Pao-Hsien Chu Shao-Chi Chen Ting-Hein Lee |
| author_facet | Hou-Yu Chiang Pao-Hsien Chu Shao-Chi Chen Ting-Hein Lee |
| author_sort | Hou-Yu Chiang |
| collection | DOAJ |
| description | A molecular link between the milk fat globule–epidermal growth factor 8 (MFG-E8), activation of vascular calcification driver TGF-β1 and osteogenic differentiation of vascular smooth muscle cells suggests that MFG-E8 could be a therapeutic target for vascular calcification. |
| first_indexed | 2024-12-11T07:23:50Z |
| format | Article |
| id | doaj.art-d56e8a15c6f441079a27e2775c2b6651 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-12-11T07:23:50Z |
| publishDate | 2022-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-d56e8a15c6f441079a27e2775c2b66512022-12-22T01:16:01ZengNature PortfolioCommunications Biology2399-36422022-04-015111310.1038/s42003-022-03313-zMFG-E8 promotes osteogenic transdifferentiation of smooth muscle cells and vascular calcification by regulating TGF-β1 signalingHou-Yu Chiang0Pao-Hsien Chu1Shao-Chi Chen2Ting-Hein Lee3Department of Anatomy, College of Medicine, Chang Gung UniversityDivision of Cardiology, Department of Internal Medicine, Chang Gung Memorial HospitalDepartment of Anatomy, College of Medicine, Chang Gung UniversityDepartment of Anatomy, College of Medicine, Chang Gung UniversityA molecular link between the milk fat globule–epidermal growth factor 8 (MFG-E8), activation of vascular calcification driver TGF-β1 and osteogenic differentiation of vascular smooth muscle cells suggests that MFG-E8 could be a therapeutic target for vascular calcification.https://doi.org/10.1038/s42003-022-03313-z |
| spellingShingle | Hou-Yu Chiang Pao-Hsien Chu Shao-Chi Chen Ting-Hein Lee MFG-E8 promotes osteogenic transdifferentiation of smooth muscle cells and vascular calcification by regulating TGF-β1 signaling Communications Biology |
| title | MFG-E8 promotes osteogenic transdifferentiation of smooth muscle cells and vascular calcification by regulating TGF-β1 signaling |
| title_full | MFG-E8 promotes osteogenic transdifferentiation of smooth muscle cells and vascular calcification by regulating TGF-β1 signaling |
| title_fullStr | MFG-E8 promotes osteogenic transdifferentiation of smooth muscle cells and vascular calcification by regulating TGF-β1 signaling |
| title_full_unstemmed | MFG-E8 promotes osteogenic transdifferentiation of smooth muscle cells and vascular calcification by regulating TGF-β1 signaling |
| title_short | MFG-E8 promotes osteogenic transdifferentiation of smooth muscle cells and vascular calcification by regulating TGF-β1 signaling |
| title_sort | mfg e8 promotes osteogenic transdifferentiation of smooth muscle cells and vascular calcification by regulating tgf β1 signaling |
| url | https://doi.org/10.1038/s42003-022-03313-z |
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