Effect of glucagon-like peptide-1 receptor agonists on glycemic control, and weight reduction in adults: A multivariate meta-analysis.
<h4>Aims</h4>To explore the effect of glucagon-like peptide-1 receptor agonist (GLP-1 RAs) on glycemic control and weight reduction in adults.<h4>Methods</h4>Databases were searched from August 2021 to March 2022. Data were analyzed using mean difference (MD) values with 95%...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2023-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0278685 |
| _version_ | 1811176412525101056 |
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| author | Tzu-Lin Yeh Ming-Chieh Tsai Wen-Hsuan Tsai Yu-Kang Tu Kuo-Liong Chien |
| author_facet | Tzu-Lin Yeh Ming-Chieh Tsai Wen-Hsuan Tsai Yu-Kang Tu Kuo-Liong Chien |
| author_sort | Tzu-Lin Yeh |
| collection | DOAJ |
| description | <h4>Aims</h4>To explore the effect of glucagon-like peptide-1 receptor agonist (GLP-1 RAs) on glycemic control and weight reduction in adults.<h4>Methods</h4>Databases were searched from August 2021 to March 2022. Data were analyzed using mean difference (MD) values with 95% confidence intervals (CIs). Both random-and fixed-effect models were employed. Heterogeneity was explored using pre-specified subgroup analyses and meta-regression. Structural equation modeling fitting was used for the multivariate meta-analysis.<h4>Results</h4>A total of 31 double-blind randomized controlled trials with 22,948 participants were included in the meta-analysis. The MD and 95% CI of the pooled GLP1-RA-induced change in the glycated hemoglobin level was -0.78% (-0.97%, -0.60%) in the random-effects model and -0.45% (-0.47%, -0.44%) in the fixed-effect model, with a high heterogeneity (I2 = 97%). The pooled body weight reduction was -4.05 kg (-5.02 kg, -3.09 kg) in the random-effects model and -2.04 kg (-2.16 kg, -1.92 kg) in the fixed-effect model (I2 = 98%). The standardized pooled correlation coefficient between HbA1c levels and body weight was -0.42. A negative correlation between glycemic control and weight reduction was obtained.<h4>Conclusion</h4>Long-acting GLP-1 RAs significantly reduced the glycated hemoglobin level and body weight in adults. |
| first_indexed | 2024-04-10T19:52:11Z |
| format | Article |
| id | doaj.art-d56e8cb3f2814789925176a6701323e9 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-10T19:52:11Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-d56e8cb3f2814789925176a6701323e92023-01-28T05:30:56ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-01181e027868510.1371/journal.pone.0278685Effect of glucagon-like peptide-1 receptor agonists on glycemic control, and weight reduction in adults: A multivariate meta-analysis.Tzu-Lin YehMing-Chieh TsaiWen-Hsuan TsaiYu-Kang TuKuo-Liong Chien<h4>Aims</h4>To explore the effect of glucagon-like peptide-1 receptor agonist (GLP-1 RAs) on glycemic control and weight reduction in adults.<h4>Methods</h4>Databases were searched from August 2021 to March 2022. Data were analyzed using mean difference (MD) values with 95% confidence intervals (CIs). Both random-and fixed-effect models were employed. Heterogeneity was explored using pre-specified subgroup analyses and meta-regression. Structural equation modeling fitting was used for the multivariate meta-analysis.<h4>Results</h4>A total of 31 double-blind randomized controlled trials with 22,948 participants were included in the meta-analysis. The MD and 95% CI of the pooled GLP1-RA-induced change in the glycated hemoglobin level was -0.78% (-0.97%, -0.60%) in the random-effects model and -0.45% (-0.47%, -0.44%) in the fixed-effect model, with a high heterogeneity (I2 = 97%). The pooled body weight reduction was -4.05 kg (-5.02 kg, -3.09 kg) in the random-effects model and -2.04 kg (-2.16 kg, -1.92 kg) in the fixed-effect model (I2 = 98%). The standardized pooled correlation coefficient between HbA1c levels and body weight was -0.42. A negative correlation between glycemic control and weight reduction was obtained.<h4>Conclusion</h4>Long-acting GLP-1 RAs significantly reduced the glycated hemoglobin level and body weight in adults.https://doi.org/10.1371/journal.pone.0278685 |
| spellingShingle | Tzu-Lin Yeh Ming-Chieh Tsai Wen-Hsuan Tsai Yu-Kang Tu Kuo-Liong Chien Effect of glucagon-like peptide-1 receptor agonists on glycemic control, and weight reduction in adults: A multivariate meta-analysis. PLoS ONE |
| title | Effect of glucagon-like peptide-1 receptor agonists on glycemic control, and weight reduction in adults: A multivariate meta-analysis. |
| title_full | Effect of glucagon-like peptide-1 receptor agonists on glycemic control, and weight reduction in adults: A multivariate meta-analysis. |
| title_fullStr | Effect of glucagon-like peptide-1 receptor agonists on glycemic control, and weight reduction in adults: A multivariate meta-analysis. |
| title_full_unstemmed | Effect of glucagon-like peptide-1 receptor agonists on glycemic control, and weight reduction in adults: A multivariate meta-analysis. |
| title_short | Effect of glucagon-like peptide-1 receptor agonists on glycemic control, and weight reduction in adults: A multivariate meta-analysis. |
| title_sort | effect of glucagon like peptide 1 receptor agonists on glycemic control and weight reduction in adults a multivariate meta analysis |
| url | https://doi.org/10.1371/journal.pone.0278685 |
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